Results 51 to 60 of about 72,689 (297)

Pengaruh Leptin terhadap Kadar Interleukin 6 Serum Tikus yang Diberi Pakan Tinggi Lemak

Mutiara Medika, 2014
Pada keadaan obesitas, meningkatnya jumlah sel lemak merupakan salah satu penyebab meningkatnya sitokin proinflamasi seperti IL-6. Obesitas dapat dimulai dengan terjadinya resistensi leptin.
Daniel Setiawan, Soemardini Soemardini, Rasjad M. Indra   +2 more
doaj   +1 more source

Role of Leptin in Cardiovascular Diseases

Frontiers in Endocrinology, 2020
The adipocyte-derived adipokine leptin exerts pleiotropic effects, which are essential for the regulation of energy balance and cell metabolism, for controlling inflammatory and immune responses, and for the maintenance of homeostasis of the ...
Mareike S. Poetsch, Anna Strano, Kaomei Guan   +2 more
doaj   +1 more source

The role of leptin in leptin resistance and obesity

Physiology & Behavior, 2006
Although the presence of hyperleptinemia with leptin resistance and obesity has long been recognized, a causal role of elevated leptin in these biological states remains unclear. This article summarizes some recent work from our laboratory supporting the concept that leptin, in and of itself, promotes leptin resistance and such resistance compounds the
Research Service, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, United States ( host institution ), Zhang, Yi ( author ), Scarpace, Philip J. ( author )   +2 more
openaire   +3 more sources

Flurbiprofen Ameliorates Glucose Deprivation-Induced Leptin Resistance [PDF]

Frontiers in Pharmacology, 2016
Leptin resistance is one of the mechanisms involved in the pathophysiology of obesity. The present study showed that glucose deprivation inhibited leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) and signal transducer and activator of transcription 5 (STAT5) in neuronal cells.
Hosoi, Toru, Suyama, Yuka, Kayano, Takaaki, Ozawa, Koichiro   +3 more
openaire   +3 more sources

PLA2G16‐Mediated Tetracosatetraenoic Acid Rewires Fatty Acid Oxidation to Impair CD8+ T Cell Immune Function in Promoting Breast Cancer Lung Metastasis

Advanced Science, EarlyView.
Illustrating how tumor‐derived PLA2G16 regulates tetracosatetraenoic acid (C24:4 (n‐6)) accumulation and CD8+ T cell activation via the C24:4‐PPARα‐FAO axis in early metastatic niches, thereby promoting lung metastasis of triple‐negative breast cancer.
Yubi Gan, Die Meng, Lei Lang, Jing Luo, Peijin Dai, Chao Chang, Zexiu Lu, Yuetong Guo, Rui Wang, Shanchun Chen, Xi Tang, Yixuan Hou, Dongmei Tan, Manran Liu   +13 more
wiley   +1 more source

Age-associated weight gain, leptin, and SIRT1: a possible role for hypothalamic SIRT1 in the prevention of weight gain and aging through modulation of leptin sensitivity

Frontiers in Endocrinology, 2015
The hypothalamus is the principal regulator of body weight and energy balance. It modulates both energy intake and energy expenditure by sensing the energy status of the body through neural inputs from the periphery as well as direct humoral inputs ...
Tsutomu eSasaki
doaj   +1 more source

Recent advances in understanding leptin signaling and leptin resistance

American Journal of Physiology-Endocrinology and Metabolism, 2009
The brain controls energy homeostasis and body weight by integrating various metabolic signals. Leptin, an adipose-derived hormone, conveys critical information about peripheral energy storage and availability to the brain. Leptin decreases body weight by both suppressing appetite and promoting energy expenditure.
David L, Morris, Liangyou, Rui
openaire   +3 more sources

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

The Role of SOCS-3 in Leptin Signaling and Leptin Resistance [PDF]

Journal of Biological Chemistry, 1999
We earlier demonstrated that leptin induces expression of SOCS-3 mRNA in the hypothalamus. Furthermore, transfection data suggest that SOCS-3 is an inhibitor of leptin signaling. However, little is known about the regulation of SOCS-3 expression by leptin and the mechanism by which SOCS-3 inhibits leptin action.
C, Bjørbaek, K, El-Haschimi, J D, Frantz, J S, Flier   +3 more
openaire   +2 more sources