Results 71 to 80 of about 80,968 (287)

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Leptin resistance in patients with chronic schizophrenia

Psychiatria i Psychologia Kliniczna, 2019
Aim: Leptin is produced by the adipose tissue and reduces body weight by decreasing appetite and increasing metabolism. Patients treated with antipsychotics often have treatment-induced weight-gain, leading to other metabolic complications.
Adam Wysokiński, Anna Dietrich-Muszalska   +1 more
doaj   +1 more source

A translational multimodal machine‐learning prototype predicting valproate response in epilepsy treatment

Epilepsia, EarlyView.
Abstract Objective Epilepsy affects ~1% of the global population and often requires lifelong antiseizure medication (ASM) therapy. Valproic acid (VPA) is a commonly prescribed first‐line ASM, yet only approximately half of patients achieve sustained seizure freedom. Treatment selection remains largely empirical.
Simeon Platte, Afsheen Kumar, Giorgia Guerini, Massimo Pandolfo, Denise Haslinger, Colin B. Josephson, Guillermo Delgado‐García, Navprabhjot Kaur, Michaela‐Pauline Lux, Heiko Stempfle, Chantal Depondt, Reetta Kälviäinen, Felix Rosenow, Sophie von Brauchitsch, Karl Martin Klein, Andreas G. Chiocchetti   +15 more
wiley   +1 more source

Hyperleptinemia in patients with gastroesophageal reflux disease and obesity: approaches to the assessment and prevention of leptin resistance

Gastroenterologìa
Background. Gastroesophageal reflux disease (GERD) and obesity remain the most common comorbid pathology, which significantly affects the deterioration of the quality of life of patients.
Л.М. Мосійчук, О.М. Татарчук, І.А. Кленіна, О.М. Шевцова, О.П. Петішко   +4 more
doaj   +1 more source

Agreement between fingertip-capillary and antecubital-venous appetite-related peptides [PDF]

, 2014
Background: The present study examined the agreement between fingertip-capillary and antecubital-venous measures of appetite-related peptides. Methods: Simultaneous fingertip-capillary and antecubital-venous blood samples were collected from 19 ...
Stevenson, Emma, Gonzalez, Javier Thomas, Rumbold, Penny Louise Sheena, Thomas, Kevin, Green, Benjamin, Green, Benjamin Paul, Gonzalez, Javier, Rumbold, Penny   +7 more
core   +1 more source

Dietary Components in the Development of Leptin Resistance [PDF]

Advances in Nutrition, 2013
Classically, leptin resistance has been associated with increased body fat and circulating leptin levels, and the condition is believed to contribute to the onset and/or maintenance of obesity. Although a great deal is known about the central nervous system mechanisms mediating leptin resistance, considerably less is known about the role of diet in ...
Joseph R, Vasselli, Philip J, Scarpace, Ruth B S, Harris, William A, Banks   +3 more
openaire   +2 more sources

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Association of Leptin and Leptin receptor Gene polymorphisms with Insulin resistance in pregnant women: A cross-sectional study [version 3; peer review: 3 approved]

F1000Research
Introduction Leptin, along with its receptor, are linked with mechanisms affecting a diverse array of pregnancy-specific pathologies that include gestational diabetes and intrauterine growth restriction.
Usha Adiga, Tirthal Rai, Nandit Banawalikar   +2 more
doaj   +1 more source

Leptin Resistance After Heart Transplantation [PDF]

European Journal of Heart Failure, 2010
Cardiac cachexia occurs in severe heart failure (HF).1,2 Heart transplantation (HTx) is associated with weight gain and the frequent development of obesity. Although this weight gain has been attributed to glucocorticoid therapy, it is more dramatic than after other solid organ transplants, despite similar steroid regimens, and also unrelated to ...
Lars H, Lund, Pamela, Freda, Jill J, Williams, John J, LaManca, Thierry H, LeJemtel, Donna M, Mancini   +5 more
openaire   +2 more sources

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source