Results 81 to 90 of about 134,529 (291)
The Role of SOCS-3 in Leptin Signaling and Leptin Resistance [PDF]
Journal of Biological Chemistry, 1999 We earlier demonstrated that leptin induces expression of SOCS-3 mRNA in the hypothalamus. Furthermore, transfection data suggest that SOCS-3 is an inhibitor of leptin signaling. However, little is known about the regulation of SOCS-3 expression by leptin and the mechanism by which SOCS-3 inhibits leptin action.
C, Bjørbaek +3 more
openaire +2 more sources
ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira +12 more
wiley +1 more source
Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
GastroenterologìaBackground. Gastroesophageal reflux disease (GERD) and obesity remain the most common comorbid pathology, which significantly affects the deterioration of the quality of life of patients.
Л.М. Мосійчук +4 more
doaj +1 more source
Leptin resistance in patients with chronic schizophrenia
Psychiatria i Psychologia Kliniczna, 2019 Aim: Leptin is produced by the adipose tissue and reduces body weight by decreasing appetite and increasing metabolism. Patients treated with antipsychotics often have treatment-induced weight-gain, leading to other metabolic complications.
Adam Wysokiński +1 more
doaj +1 more source
Effects of Prior Acute Exercise on Circulating Cytokine Concentration Responses to a High-fat Meal [PDF]
, 2013 High-fat meal consumption alters the circulating cytokine profile and contributes to cardiometabolic diseases. A prior bout of exercise can ameliorate the triglyceride response to a high-fat meal, but the interactive effects of exercise and high-fat ...
Brandauer, Josef +5 more
core +2 more sources
Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome
Food Biomacromolecules, EarlyView.Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley +1 more source
F1000ResearchIntroduction Leptin, along with its receptor, are linked with mechanisms affecting a diverse array of pregnancy-specific pathologies that include gestational diabetes and intrauterine growth restriction.
Usha Adiga +2 more
doaj +1 more source
Androgens and Hypertension in Men and Women: a Unifying View. [PDF]
, 2017 This review was designed to revaluate the androgen role on the mechanisms of hypertension and cardiovascular risks in both men and women. Sex steroids are involved in the regulation of blood pressure, but pathophysiological mechanism is not well ...
Carmina, E. 4. +4 more
core +1 more source
The immunohistochemical expression of leptin in lymph node metastasis from laryngeal squamous cell carcinoma (SCC) [PDF]
, 2020 Introduction: Leptin is a proteohormone produced predominantly by white adipocytes and primarily known for its key role in the control of food intake and sense of satiety.
D'Alessi S +7 more
core +1 more source