Results 81 to 90 of about 74,494 (249)
New pharmacological perspectives for the leptin receptor in the treatment of obesity
Frontiers in Endocrinology, 2014 After its discovery in 1994, leptin became the great hope as an anti-obesity treatment based on its ability to reduce food intake and increase energy expenditure.
Clara eRoujeau +2 more
doaj +1 more source
Leptin resistance in obesity: An epigenetic landscape
Life Sciences, 2015 Leptin is an adipocyte-secreted hormone that inhibits food intake and stimulates energy expenditure through interactions with neuronal pathways in the brain, particularly pathways involving the hypothalamus. Intact functioning of the leptin route is required for body weight and energy homeostasis.
Casanueva Freijo, Felipe +5 more
openaire +3 more sources
New‐Onset Type 2 Diabetes Mellitus and Cancer Risk: A Matched Cohort Study in China Kadoorie Biobank
International Journal of Cancer, EarlyView.ABSTRACT The prevalence of type 2 diabetes mellitus (T2DM) is rising rapidly in China and is linked to increased cancer risk, but causality remains unclear due to biases. We examined the causal effect of T2DM on cancer risk using bias‐minimizing methods.
Mengying Wang +9 more
wiley +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Background Obesity increases the risk of obstetric and neonatal complications, and adherence to lifestyle interventions during pregnancy presents a challenge. Patient and public involvement (PPI) in trials may foster a more patient‐centered approach, potentially improving compliance with intervention and follow up.
Elisabeth Garcia Vilaplana +6 more
wiley +1 more source
Obesity as a Risk Factor for Alzheimer’s Disease: Implication of Leptin and Glutamate
Frontiers in Neuroscience, 2019 Obesity is known to induce leptin and insulin resistance. Leptin is a peptide hormone synthesized in adipose tissue that mainly regulates food intake.
Ana Lloret +4 more
doaj +1 more source
The Role of Dietary Components in Leptin Resistance [PDF]
Advances in Nutrition, 2012 Leptin resistance has been defined as reduced or absent responsiveness to the feeding and body weight inhibitory effects of the hormone in obese individuals compared with normal (lean) controls. Classically, leptin resistance has been associated with increased body fat and circulating leptin levels, and the effect is thought to contribute to the ...
openaire +2 more sources
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective Maternal obesity and excess gestational weight gain (GWG) are linked to adverse perinatal outcomes, potentially via disruption of the maternal–fetal stress axis. Placental HSD11B2 protects the fetus from excess glucocorticoids and may influence fetal programming during maternal metabolic stress.
Thorsten Braun +13 more
wiley +1 more source
iMetaOmics, EarlyView.The gut–mammary axis integrates intestinal health with mammary function through neural, endocrine, and immune pathways. Nutritional interventions (probiotics, prebiotics, metabolites) improve gut microecology, generating microbial signals that travel via the axis to the mammary gland. There, they relieve inflammation, enhance milk quality and lactation,
Aolong Zhou +29 more
wiley +1 more source
Journal of the Science of Food and Agriculture, EarlyView.Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen +2 more
wiley +1 more source
Open Medicine, 2014 Cardiovascular risk of prediabetes is still subject to controversies. We analyzed the associations between insulin resistance, adipokines and incipient atherosclerosis estimated by intima-media thickness (IMT) in a cross-sectional study on 122 ...
Mihai Bogdan Mircea +3 more
doaj +1 more source