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F1000Research, 2022 Introduction: Leptin is an adipokine hormone that regulates insulin sensitivity and lipid profile, which may contribute to complications like gestational diabetes.The goal of the study was to examine if there was a link between the leptin (LEP)/leptin ...
Usha Adiga +2 more
doaj
Scientific Reports, 2017 Leptin signaling in the hypothalamus plays a crucial role in the regulation of body weight. Leptin resistance, in which leptin signaling is disrupted, is a major obstacle to the improvement of obesity.
T. Shintani +7 more
semanticscholar +1 more source
Leptin resistance after heart transplantation [PDF]
European Journal of Heart Failure, 2010 Cardiac cachexia occurs in severe heart failure (HF).1,2 Heart transplantation (HTx) is associated with weight gain and the frequent development of obesity. Although this weight gain has been attributed to glucocorticoid therapy, it is more dramatic than after other solid organ transplants, despite similar steroid regimens, and also unrelated to ...
Pamela U. Freda +5 more
openaire +3 more sources
Emerging Nanotechnology Strategies for Obesity Therapy
Advanced Science, EarlyView.Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang +5 more
wiley +1 more source
Role of Leptin in Cardiovascular Diseases
Frontiers in Endocrinology, 2020 The adipocyte-derived adipokine leptin exerts pleiotropic effects, which are essential for the regulation of energy balance and cell metabolism, for controlling inflammatory and immune responses, and for the maintenance of homeostasis of the ...
Mareike S. Poetsch +2 more
doaj +1 more source
In preeclampsia, maternal third trimester subcutaneous adipocyte lipolysis is more resistant to suppression by insulin than in healthy pregnancy [PDF]
, 2014 Obesity increases preeclampsia risk, and maternal dyslipidemia may result from exaggerated adipocyte lipolysis. We compared adipocyte function in preeclampsia with healthy pregnancy to establish whether there is increased lipolysis.
Forrest, Rachel. +5 more
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Advanced Science, EarlyView.Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen +18 more
wiley +1 more source
Journal of Lipid Research, 2008 Conjugated linoleic acid (CLA) induces insulin resistance preceded by rapid depletion of the adipokines leptin and adiponectin, increased inflammation, and hepatic steatosis in mice.
Angela A. Wendel +3 more
doaj
Pengaruh Leptin terhadap Kadar Interleukin 6 Serum Tikus yang Diberi Pakan Tinggi Lemak
Mutiara Medika, 2014 Pada keadaan obesitas, meningkatnya jumlah sel lemak merupakan salah satu penyebab meningkatnya sitokin proinflamasi seperti IL-6. Obesitas dapat dimulai dengan terjadinya resistensi leptin.
Daniel Setiawan +2 more
doaj +1 more source
Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity [PDF]
, 2014 Aims Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that promotes bioactive mediator ...
Baust, Jeff +14 more
core +1 more source