Correction: Anthrax Toxin Receptor 2–Dependent Lethal Toxin Killing In Vivo.
PLoS Pathogens, 2008 The authors also acknowledge support for this work from National Institutes of Health grant AI48489.
Heather M Scobie +8 more
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Suppressive effects of anthrax lethal toxin on megakaryopoiesis. [PDF]
PLoS ONE, 2013 Anthrax lethal toxin (LT) is a major virulence factor of Bacillus anthracis. LT challenge suppresses platelet counts and platelet function in mice, however, the mechanism responsible for thrombocytopenia remains unclear.
Po-Kong Chen +11 more
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Anthrax lethal toxin co-complexes are stabilized by contacts between adjacent lethal factors [PDF]
Journal of General Physiology, 2016 Anthrax toxin is a three-protein toxin that must first assemble before carrying out its physiological function of menacing its eukaryotic host. Much has been done, therefore, to study its assembly both in vitro and on cell surfaces. The three proteins that comprise the toxin are protective antigen (
Krantz BA.
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Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B [PDF]
Toxins, 2016 Lethal Toxin from Clostridium sordellii (TcsL) and Toxin B from Clostridium difficile (TcdB) belong to the family of the “Large clostridial glycosylating toxins.” These toxins mono-O-glucosylate low molecular weight GTPases of the Rho and Ras families by
Harald Genth, Ilona Schelle, Ingo Just
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Neutro“feels” lethal toxin [PDF]
Journal of Leukocyte Biology, 2020 Discussion on lethal toxin-induced acute IL-1β production as dependent on NLRP1b and caspase-1, PAD4, cell-free DNA and neutrophils.
Lalita Mazgaeen, Prajwal Gurung
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Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. [PDF]
PLoS Pathogens, 2006 Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal
Heather M Scobie +8 more
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Correlation between in vitro cytotoxicity and in vivo lethal activity in mice of epsilon toxin mutants from Clostridium perfringens. [PDF]
PLoS ONE, 2014 Epsilon toxin (Etx) from Clostridium perfringens is a pore-forming protein with a lethal effect on livestock, producing severe enterotoxemia characterized by general edema and neurological alterations.
Jonatan Dorca-Arévalo +5 more
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Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling. [PDF]
PLoS Pathogens, 2017 Bacillus anthracis, the causative agent of anthrax, secretes lethal toxin that down-regulates immune functions. Translocation of B. anthracis across mucosal epithelia is key for its dissemination and pathogenesis.
Sudarshan Seshadri +3 more
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Chimeric Antibody Engineering Against Bacillus anthracis Lethal Toxin: Neutralization Efficacy and Mechanism of Action [PDF]
ToxinsBacillus anthracis has three main virulence factors: an extracellular capsule and two binary toxins (lethal toxin—consists of a lethal factor and a protective antigen, and edema toxin—consists of an edema factor and a protective antigen).
Olga V. Kalmantaeva +7 more
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Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system [PDF]
mBioBacillus anthracis causes anthrax through a combination of bacterial infection and toxemia. As a major virulence factor of B. anthracis, anthrax lethal toxin (LT) is a zinc-dependent metalloproteinase, exerting its cytotoxicity through proteolytic ...
Jie Liu +5 more
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