Results 1 to 10 of about 94,541 (354)

Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin [PDF]

PLoS ONE, 2013
Background:Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels.
A Kronhardt, A Messmer, A Ménard, A Ménard, AA Verveen, AF Kintzer, AM Friedlander, Anika Bronnhuber, AW Artenstein, BA Krantz, C Andersen, C Bachmeyer, C Bachmeyer, C Petosa, Christoph Beitzinger, CT Bahner, D Blöcker, D Blöcker, DB Lacy, EM Nestorovich, EM Nestorovich, F Conti, F Orlik, F Orlik, F Tonello, F Tonello, F Wohnsland, G Hajós, G Timári, G Vitale, György Hajós, H Barth, H Barth, Holger Barth, I Zornetta, J Sun, J Wesche, JA Young, JC Milne, JL Elliott, K Cunningham, KA Bradley, Kerstin Duscha, L Abrami, L Abrami, L Abrami, L Abrami, L Song, Ludger Johannes, M Eigen, M Mock, Markus Huber-Lang, MJ Brown, NS Duesbery, PC Hanna, R Benz, R Benz, R Palkó, R Pellizzari, RJ Collier, RO Blaustein, RO Blaustein, Roland Benz, S Nekolla, SH Leppla, SM Bezrukov, SM Bezrukov, T Neumeyer, T Neumeyer, T Neumeyer, TC Dixon, V Escuyer, VA Karginov, VA Karginov, VA Karginov, Y Singh, Zsuzsanna Riedl   +76 more
core   +35 more sources

Suppressive effects of anthrax lethal toxin on megakaryopoiesis. [PDF]

PLoS One, 2013
Anthrax lethal toxin (LT) is a major virulence factor of Bacillus anthracis. LT challenge suppresses platelet counts and platelet function in mice, however, the mechanism responsible for thrombocytopenia remains unclear. LT inhibits cellular mitogen-activated protein kinases (MAPKs), which are vital pathways responsible for cell survival ...
Chen PK, Chang HH, Lin GL, Wang TP, Lai YL, Lin TK, Hsieh MC, Kau JH, Huang HH, Hsu HL, Liao CY, Sun DS.   +11 more
europepmc   +7 more sources

Neutro"feels" lethal toxin. [PDF]

J Leukoc Biol, 2020
Discussion on lethal toxin-induced acute IL-1β production as dependent on NLRP1b and caspase-1, PAD4, cell-free DNA and neutrophils.
Mazgaeen L, Gurung P.
europepmc   +4 more sources

Anthrax lethal toxin co-complexes are stabilized by contacts between adjacent lethal factors. [PDF]

J Gen Physiol, 2016
Anthrax toxin is a three-protein toxin that must first assemble before carrying out its physiological function of menacing its eukaryotic host. Much has been done, therefore, to study its assembly both in vitro and on cell surfaces. The three proteins that comprise the toxin are protective antigen (
Krantz BA.
europepmc   +5 more sources

Cisplatin Inhibition of Anthrax Lethal Toxin [PDF]

Antimicrobial Agents and Chemotherapy, 2006
ABSTRACT Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component, protective antigen (PA), which delivers the enzymatic component, lethal factor (LF), into cells.
Robin E. Lindeman, Stephen H. Leppla, Mahtab Moayeri, Jason F. Wiggins   +3 more
openaire   +3 more sources

Induction of autophagy by anthrax lethal toxin [PDF]

Biochemical and Biophysical Research Communications, 2009
Autophagy is an evolutionary conserved intracellular process whereby cells break down long-lived proteins and organelles. Accumulating evidences suggest increasing physiological significance of autophagy in pathogenesis of infectious diseases. Anthrax lethal toxin (LT) exerts its influence on numerous cells and herein, we report a novel effect of LT ...
Caroline M. Kusuma, Hao A. Vu, Lena J. St. John, Yian Kim Tan, Ken Alibek, Aiguo Wu   +5 more
openaire   +3 more sources

Anthrax toxin: a tripartite lethal combination¹ [PDF]

FEBS Letters, 2002
Anthrax is a severe bacterial infection that occurs when Bacillus anthracis spores gain access into the body and germinate in macrophages, causing septicemia and toxemia. Anthrax toxin is a binary A–B toxin composed of protective antigen (PA), lethal factor (LF), and edema factor (EF).
ASCENZI P, VISCA P, IPPOLITO G, SPALLAROSSA, ANDREA, BOLOGNESI M, MONTECUCCO C.   +5 more
openaire   +7 more sources

Cellular and systemic effects of anthrax lethal toxin and edema toxin [PDF]

Molecular Aspects of Medicine, 2009
Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and can replicate the lethality and symptoms associated with the disease. This review provides an overview of our current understanding of anthrax toxin effects in animal models and the cytotoxicity (necrosis and apoptosis) induced by LT in different cells.
Mahtab Moayeri, Stephen H. Leppla
openaire   +3 more sources

Purification and characterization of the lethal toxin (alpha-toxin) of Clostridium septicum [PDF]

Infection and Immunity, 1992
Clostridium septicum lethal (alpha-toxin) was purified and found to be a basic protein (pI 8.4) of approximately 48 kDa that is both lethal and hemolytic. The alpha-toxin had a hemolytic activity of approximately 2 x 10(7) hemolytic units per mg and a 50% lethal dose of approximately 10 micrograms/kg of body weight for mice.
A. Bryant, Jimmy D. Ballard, D. Stevens, Rodney K. Tweten   +3 more
openaire   +3 more sources

Contribution of Lethal Toxin and Edema Toxin to the Pathogenesis of Anthrax Meningitis [PDF]

Infection and Immunity, 2011
ABSTRACT Bacillus anthracis is a Gram-positive spore-forming bacterium that causes anthrax disease in humans and animals. Systemic infection is characterized by septicemia, toxemia, and meningitis, the main neurological complication associated with high mortality. We have shown previously that B. anthracis
Kelly S. Doran, Roberta A. Gottlieb, Tamsin R. Sheen, Christian Renken, Celia M. Ebrahimi   +4 more
openaire   +3 more sources