Inositol Hexakisphosphate-dependent Processing of Clostridium sordellii Lethal Toxin and Clostridium novyi α-Toxin [PDF]
Journal of Biological Chemistry, 2011 Clostridium sordellii lethal toxin and Clostridium novyi α-toxin, which are virulence factors involved in the toxic shock and gas gangrene syndromes, are members of the family of clostridial glucosylating toxins. The toxins inactivate Rho/Ras proteins by glucosylation or attachment of GlcNAc (α-toxin).
Guttenberg, Gregor +6 more
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Anthrax Lethal Toxin Induces Human Endothelial Cell Apoptosis [PDF]
Infection and Immunity, 2004 ABSTRACT Because of its ease of dispersal and high lethality, Bacillus anthracis is one of the most feared biowarfare agents. A better understanding of anthrax pathogenesis is urgently needed to develop new therapies for systemic disease that is relatively unresponsive to antibiotics. Although experimental
James E. Kirby
openaire +3 more sources
Rational Drug Designing Strategies and Inhibitor Optimization: Anthrax Lethal Toxin Factor [PDF]
International Journal Bioautomation, 2012 Anthrax toxin protein protective antigen, edema factor and lethal factor are secreted by Bacillus anthracis bacteria causes several adverse effects on human as well as on ruminant animals and considered as serious biological weapons. Lethal toxin protein
Pawan Kumar Jayaswal +2 more
doaj +1 more source
Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin [PDF]
, 2013 Background:Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels.
A Kronhardt +76 more
core +19 more sources
The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin. [PDF]
EMBO J, 2019 Xu H +6 more
europepmc +3 more sources
Immunization of Mice with Anthrax Protective Antigen Limits Cardiotoxicity but Not Hepatotoxicity Following Lethal Toxin Challenge. [PDF]
Toxins (Basel), 2015 Devera TS +4 more
europepmc +3 more sources
Cisplatin Inhibition of Anthrax Lethal Toxin [PDF]
Antimicrobial Agents and Chemotherapy, 2006 ABSTRACT Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component, protective antigen (PA), which delivers the enzymatic component, lethal factor (LF), into cells.
Mahtab, Moayeri +3 more
openaire +2 more sources
Scientific Reports, 2021 The advanced biomimetic mineralization technology was applied to protect the Botulinum neurotoxin type D, and the processing of the mineralization granule of botulinum toxin type D was successfully screened.
Shengqing Li +6 more
doaj +1 more source
Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol. [PDF]
PLoS ONE, 2008 Bacillus anthracis is the bacterium responsible for causing anthrax. The ability of B. anthracis to cause disease is dependent on a secreted virulence factor, lethal toxin, that promotes survival of the bacteria in the host by impairing the immune ...
Sarah Chapelsky +3 more
doaj +1 more source
Anthrax Edema Toxin Sensitizes DBA/2J Mice to Lethal Toxin [PDF]
Infection and Immunity, 2007 ABSTRACT Anthrax toxin is made up of three separate protein components: the receptor-binding protective antigen (PA), the adenylyl cyclase edema factor (EF), and the metalloproteinase lethal factor (LF). EF and PA constitute edema toxin (ET), which causes edema when injected subcutaneously.
Aaron M, Firoved +5 more
openaire +2 more sources