Results 11 to 20 of about 94,541 (354)
Purification of a Lethal Toxin of Edwardsiella tarda.
Fish Pathology, 1996 A toxin lethal to fish was purified from extracellular products (ECP) of Edwardsiella tarda by ion exchange chromatography and gel filtration. The purified toxin is a protein having proteolytic activities and lethal toxicity to Japanese eel Anguilla japonica with the LD50 of 1.6μg per g of fish body weight. Molecular weight of the protein was estimated
Suprapto, Hari +3 more
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Anthrax Toxin Receptor 2–Dependent Lethal Toxin Killing In Vivo [PDF]
PLoS Pathogens, 2006 Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal ion and PA residue D683 are critical for ANTXR1-PA binding.
R. John Collier +9 more
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Toxin-induced resistance in Bacillus anthracis lethal toxin-treated macrophages [PDF]
Proceedings of the National Academy of Sciences, 2003 In the current study, we show that macrophages adaptively resist anthrax lethal toxin (LT) through a toxin-activated process termed toxin-induced resistance (TIR). TIR was triggered by pretreatment of RAW 264.7 or J774A.1 macrophages with a low dose of LT for at least 6 h, which resulted in resistance to high doses of LT for 96 h.
Jimmy D. Ballard +3 more
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The Effects of Anthrax Lethal Toxin on Host Barrier Function [PDF]
Toxins, 2011 The pathological actions of anthrax toxin require the activities of its edema factor (EF) and lethal factor (LF) enzyme components, which gain intracellular access via its receptor-binding component, protective antigen (PA). LF is a metalloproteinase with specificity for selected mitogen-activated protein kinase kinases (MKKs), but its activity is not ...
Roger D. Auth, David M. Frucht, Tao Xie
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Correction: Anthrax Toxin Receptor 2–Dependent Lethal Toxin Killing In Vivo
PLoS Pathogens, 2008 The authors also acknowledge support for this work from National Institutes of Health grant AI48489.
R. John Collier +8 more
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Oxidized ATP Protection against Anthrax Lethal Toxin [PDF]
Infection and Immunity, 2006 ABSTRACTBacillus anthracislethal toxin (LT) induces rapid lysis (<90 min) of murine macrophages from certain inbred strains. The mechanism for LT-induced cytolysis is currently unknown. We hypothesized that the ATP-activated macrophage P2X7 receptors implicated in nucleotide-mediated macrophage lysis could play a role in LT-mediated cytolysis and ...
Stephen H. Leppla +3 more
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Bacterial toxins: a table of lethal amounts [PDF]
Microbiological Reviews, 1982 D. Michael Gill
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Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling. [PDF]
PLoS Pathog, 2017 Bacillus anthracis, the causative agent of anthrax, secretes lethal toxin that down-regulates immune functions. Translocation of B. anthracis across mucosal epithelia is key for its dissemination and pathogenesis.
Seshadri S +3 more
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Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system. [PDF]
mBioBacillus anthracis causes anthrax through a combination of bacterial infection and toxemia. As a major virulence factor of B. anthracis, anthrax lethal toxin (LT) is a zinc-dependent metalloproteinase, exerting its cytotoxicity through proteolytic ...
Liu J +5 more
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Scientific Reports, 2021 The advanced biomimetic mineralization technology was applied to protect the Botulinum neurotoxin type D, and the processing of the mineralization granule of botulinum toxin type D was successfully screened.
Shengqing Li +6 more
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