Results 41 to 50 of about 1,755 (134)

A leucine aminopeptidase is involved in kinetoplast DNA segregation in Trypanosoma brucei.

PLoS Pathogens, 2017
The kinetoplast (k), the uniquely packaged mitochondrial DNA of trypanosomatid protists is formed by a catenated network of minicircles and maxicircles that divide and segregate once each cell cycle.
Priscila Peña-Diaz, Marie Vancová, Christian Resl, Mark C Field, Julius Lukeš   +4 more
doaj   +1 more source

Unravelling potential virulence factor candidates in Xanthomonas citri. subsp. citri by secretome analysis [PDF]

PeerJ, 2016
Citrus canker is a major disease affecting citrus production in Brazil. It’s mainly caused by Xanthomonas citri subsp. citri strain 306 pathotype A (Xac).
Rafael M. Ferreira, Leandro M. Moreira, Jesus A. Ferro, Marcia R.R. Soares, Marcelo L. Laia, Alessandro M. Varani, Julio C.F. de Oliveira, Maria Ines T. Ferro   +7 more
doaj   +2 more sources

Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases [PDF]

Arkivoc, 2012
The M1 alanyl aminopeptidase and M17 leucyl aminopeptidase are critical to the growth and development of malaria parasites inside host erythrocytes. Potent aminopeptidase inhibitors kill malaria parasites in culture and are also active in vivo against murine malaria. Functional recombinant enzyme studies have been used to decipher the three-dimensional
Thivierge, Karine, Mathew, Rency T., Nsangou, Desire M., Silva, Fabio L. da, Cotton, Sophie, Skinner-Adams, Tina S., Trenholme, Katharine R., Brown, Christopher L., Stack, Colin M. (R12090), Gardiner, Donald L., Dalton, John P.   +10 more
openaire   +2 more sources

A Viral RNA Silencing Suppressor Modulates Reactive Oxygen Species Levels to Induce the Autophagic Degradation of Dicer‐Like and Argonaute‐Like Proteins

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Understanding the virus‐host arms race has been a fascinating topic in virology; contributing significantly to the development of treatments and control strategies for viral diseases. CHV1 employs a sophisticated counter‐defense mechanism in its fungal host by utilizing a viral silencing suppressor to inhibit fungal FMN reductase; thereby modulating ...
Shiyu Zhai, Tianxing Pang, Shiyu Peng, Shenshen Zou, Zhiping Deng, Nobuhiro Suzuki, Zhensheng Kang, Ida Bagus Andika, Liying Sun   +8 more
wiley   +1 more source

Fish By‐Products Utilization in Food and Health: Extraction Technologies, Bioactive, and Sustainability Challenges

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Fish by‐products, often discarded, are rich sources of bioactive peptides, collagen, and omega‐3s with antioxidant, antihypertensive, and antimicrobial properties. Advanced, sustainable extraction technologies can valorize this waste into functional food, nutraceutical, and biomedical ingredients.
Muhammad Waqar, Nimra Sajjad, Qudrat Ullah, S. S. Vasanthkumar, Faiyaz Ahmed, Worawan Panpipat, Rotimi E. Aluko, Lovedeep Kaur, Manat Chaijan, Temesgen Anjulo Ageru   +9 more
wiley   +1 more source

Peeling Skin, Leukonychia, Acral Punctate Keratoses, Cheilitis and Knuckle Pads (PLACK) Syndrome: An Updated Review of Cases and Identification of a Recurrent CAST Variant in Two Patients

Pediatric Dermatology, Volume 42, Issue 6, Page 1239-1247, November/December 2025.
ABSTRACT Peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK) syndrome (OMIM616295) is an exceptionally rare autosomal recessive genodermatosis caused by loss‐of‐function pathogenic variants in the CAST gene, encoding calpastatin.
Fiona Haxho, Richard M. Haber, Janan Mohamad, Ofer Sarig, Eli Sprecher, Renée Perrier, Dana Boctor, Michele Ramien   +7 more
wiley   +1 more source

Coarse woody debris decomposition along an elevation gradient alleviates soil microbial P limitation but intensifies C limitation at Wuyishan National Park

Functional Ecology, Volume 39, Issue 8, Page 2070-2084, August 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Soil microorganisms play a vital role in biogeochemical cycles by transforming plant residues into soil organic matter through catabolic processes, thereby significantly influencing carbon (C) storage.
Fanxi Peng, Xia Xu, Wei Fan, Yan Zhu, Chenghui Ju, Wenfang Liu, Xiaochou Chen, Qinghong Geng, Xiangjin Li, Junyi Xie   +9 more
wiley   +1 more source

Long‐Term Tillage and Compost Shape Soil Microbes Under Soil Organic Carbon Equilibrium

European Journal of Soil Science, Volume 76, Issue 3, May–June 2025.
ABSTRACT Soil microorganisms are crucial in regulating soil organic matter dynamics and nutrient cycling, mediating the effects of agricultural management on soil health. Although the microbial responses to changes in soil organic carbon (SOC) are well‐documented, a knowledge gap remains regarding microbial dynamics when soils reach SOC equilibrium ...
Che‐Jen Hsiao, Muazzama Mushtaq, Gretchen F. Sassenrath, Lydia H. Zeglin, Ganga M. Hettiarachchi, Charles W. Rice   +5 more
wiley   +1 more source

The Role of Aminopeptidase ERAP1 in Human Pathology—A Review

Current Issues in Molecular Biology
Aminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for endoplasmic reticulum aminopeptidase 1), ERAP2 (coding for endoplasmic
Laura Țiburcă, Dana Carmen Zaha, Maria Claudia Jurca, Emilia Severin, Aurora Jurca, Alexandru Daniel Jurca   +5 more
doaj   +1 more source

Pharmacodynamics of the orexin type 1 (OX1) receptor in colon cancer cell models: A two‐sided nature of antagonistic ligands resulting from partial dissociation of Gq

British Journal of Pharmacology, Volume 182, Issue 7, Page 1528-1545, April 2025.
Abstract Background and Purpose Orexins have important biological effects on the central and peripheral nervous systems. Their primary ability is to regulate the sleep–wake cycle. Orexins and their antagonists, via OX1 receptor have been shown to have proapoptotic and antitumor effects on various digestive cancers cell models.
Valérie Gratio, Paulina Dragan, Laurine Garcia, Loredana Saveanu, Pascal Nicole, Thierry Voisin, Dorota Latek, Alain Couvineau   +7 more
wiley   +1 more source