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Journal of the Anus, Rectum and Colon, 2019 We systematically reviewed literature regarding "Lewy body constipation", i.e., constipation due to Lewy body diseases (LBD), with minimal neurologic symptoms.
Ryuji Sakakibara +2 more
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Evidence for divergent cortical organisation in Parkinson’s disease and Lewy Body Dementia [PDF]
Nature CommunicationsDementia is a defining feature of Lewy body disease: its timing and onset distinguish different clinical diagnoses, and its effect on quality of life is profound.
Angeliki Zarkali +7 more
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Cortical Lewy Body Dementia [PDF]
Behavioural Neurology, 1990 In cortical Lewy body dementia the distribution of Lewy bodies in the nervous system follows that of Parkinson's disease, except for their greater profusion in the cerebral cortex. The cortical tangles and plaques of Alzheimer pathology are often present,
W. R. G. Gibb
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Visual Hallucinations in Serotonergic Psychedelics and Lewy Body Diseases [PDF]
Schizophr BullNathan H. Heller +12 more
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Novel Ubiquitin Specific Protease-13 Inhibitors Alleviate Neurodegenerative Pathology
Metabolites, 2021 Ubiquitin Specific Protease-13 (USP13) promotes protein de-ubiquitination and is poorly understood in neurodegeneration. USP13 is upregulated in Alzheimer’s disease (AD) and Parkinson’s disease (PD), and USP13 knockdown via shRNA reduces neurotoxic ...
Xiaoguang Liu +5 more
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Proceedings of the National Academy of Sciences, 2006 Lewy bodies (LB) in the substantia nigra are a cardinal pathological feature of Parkinson's disease, but they occur in a number of neurodegenerative diseases and can be widespread in the nervous system. The characteristics, locations, and composition of LB are reviewed, with particular attention to α-synuclein (α-SYN), which appears to be the major ...
+5 more sources
Safety, target engagement, and biomarker effects of bosutinib in dementia with Lewy bodies
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction Bosutinib, a dual Abelson/Src inhibitor, was investigated in individuals with dementia with Lewy bodies (DLB). Methods A single site, randomized, double‐blind, placebo‐controlled study of the effects of oral bosutinib, 100 mg once daily for ...
Fernando L. Pagan +8 more
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The Lancet, 2015 The broad importance of dementia is undisputed, with Alzheimer's disease justifiably getting the most attention. However, dementia with Lewy bodies and Parkinson's disease dementia, now called Lewy body dementias, are the second most common type of degenerative dementia in patients older than 65 years.
Walker, Zuzana +3 more
openaire +5 more sources
Lewy Body Dementia Association’s Industry Advisory Council: proceedings of the second annual meeting
Alzheimer’s Research & Therapy, 2021 In 2019, the Lewy Body Dementia Association formed an Industry Advisory Council to bring together a collaborative group of stakeholders with the goal of accelerating clinical research into Lewy body dementia treatments.
Jennifer G. Goldman +18 more
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BMC Geriatrics, 2022 Background The pandemic has significantly affected care homes’ residents and families through the national visiting restrictions. However, less is known on the impact these changes have had on the care home workforce.
Kerry Hanna +8 more
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