Results 61 to 70 of about 91,122 (346)
Dementia with Lewy Bodies [PDF]
Seminars in Neurology, 2014 Dementia with Lewy bodies (DLB) is the second most common diagnosis of dementia after Alzheimer disease (AD). The essential pathologic feature is the Lewy body, a neuronal inclusion containing α-synuclein, found in brainstem nuclei and the neocortex.
Mary Catherine, Mayo, Yvette, Bordelon
openaire +2 more sources
Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football [PDF]
, 2017 IMPORTANCE: Players of American football may be at increased risk of long-term neurological conditions, particularly chronic traumatic encephalopathy (CTE).
Abdolmohammadi, Bobak +26 more
core +1 more source
NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease
Advanced Science, EarlyView.NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang +18 more
wiley +1 more source
Frontiers in Aging Neuroscience, 2022 IntroductionTo explore the combined diagnostic value of plasma Lewy body-associated proteins (p-Asyn at ser129, total α-syn, and oligomeric α-syn) for the diagnosis of PD versus healthy controls (HCs) and other PD syndromes (PDs), as well as clinical ...
Xuemiao Zhao +13 more
doaj +1 more source
Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation. [PDF]
, 2020 In Parkinson's disease, some of the first alpha-synuclein aggregates appear in the olfactory system and the dorsal motor nucleus of the vagus nerve before spreading to connected brain regions.
Brundin, Patrik +3 more
core +2 more sources
Advanced Science, EarlyView.This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu +6 more
wiley +1 more source
Neuroinflammation in Lewy body dementia. [PDF]
, 2015 Neuroinflammation is increasingly recognized as a key factor in the pathogenesis of neurodegenerative conditions. However, it remains unclear whether it has a protective or damaging role.
O'Brien, John T +2 more
core +2 more sources
A Novel Milli‐Scale Magnetic Robot Exploiting Rotation for Controlled Magnetic Particles Release
Advanced Intelligent Systems, EarlyView.Delivering magnetic particles can become a game changer in minimally invasive medicine. To cope with this challenge, a magnetically actuated milli‐scale carrier leveraging rotation to perform on‐demand tunable release of magnetic particles across multiple release events is presented.
Giordano De Angelis +3 more
wiley +1 more source
The Central Intelligence Agency’s armed Remotely Piloted Vehicle-supported counter-insurgency campaign in Pakistan – a mission undermined by unintended consequences? [PDF]
, 2014 This paper views America's 'drones-first' counter-insurgency effort in Pakistan through the lens of Merton's theory of the unintended consequences of purposive action.
Bennett, Simon
core +2 more sources
Establishment of a novel cynomolgus monkey model of hyperuricemia
Animal Models and Experimental Medicine, EarlyView.We established a novel hyperuricemia model in cynomolgus monkeys (A) via oral administration of potassium oxonate, hydrochlorothiazide, and adenine mixed in fruits and vegetables. This model (B) targets uric acid synthesis and enzymatic degradation, and (C) regulates renal and intestinal excretion, thereby stably elevating serum uric acid and serving ...
Ji‐Wei Wang +12 more
wiley +1 more source