Results 121 to 130 of about 2,296,826 (424)

Accessing Spin-Crossover Behaviour In Iron(II) Complexes Of N-Confused Scorpionate Ligands [PDF]

, 2016
The first examples of a class of N-confused tris(pyrazolyl)methane ‘scorpionate’ ligands have been prepared. The magnetic properties of their iron(II) tetrafluoroborate complexes are dictated by changing one substituent per ligand rather than three as is
Gardinier, James R., Lindeman, Sergey, Meise, Kristin J., Treleven, Alexander Richard   +3 more
core   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Time and length scales of autocrine signals in three dimensions [PDF]

, 2007
A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well
Abramowitz, Alexander M. Berezhkovskii, Batsilas, Berezhkovskii, Berezhkovskii, DeWitt, Dong, Fernandez-Sesma, Forsten, Freeman, Griffith, Janes, Kesari, Lauffenburger, Lauffenburger, Loewer, Maheshwari, Mathieu Coppey, Monine, Muratov, Nakashiro, Oehrtman, Pribyl, Pribyl, Rice, Shaw, Shoup, Shvartsman, Shvartsman, Stanislav Y. Shvartsman, Stuart C. Sealfon, Vermeer, Wiley, Wrobel, Zhu   +34 more
core   +3 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Tetra­aceto­nitrile­lithium tetra­iso­thio­cyanato­borate [PDF]

, 2013
The crystal structure of the title salt, [Li(CH3CN)4][B(NCS)4], is composed of discrete cations and anions. Both the Li and B atoms show a tetra­hedral coordination by four equal ligands. The aceto­nitrile and iso­thio­cyanate ligands are linear.
Bolte, Michael, Breunig, Jens Michael, Lerner, Hans-Wolfram, Wietelmann, Ulrich   +3 more
core   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Predicting the biological activity of selected phytochemicals in Alsophila spinulosa leaves against 4-aminobutyrate-aminotransferase: A potential antiepilepsy agents

Eclética Química
The use of medicinal plants as an alternative mean of treating various diseases has drawn the attention of several researchers. The desire to find lasting solutions to epilepsy among humans increases every day.
Oyebamiji Abel Kolawole, Olujinmi Faith Eniola, Akintelu Sunday Adewale, Adetuyi Babatunde, Ogunlana Olubanke, Semire Banjo, Akintayo Emmanuel Temitope, Akintayo Cecilia Olufunke, Babalola Jonathan Oyebamiji, Olawoye Bolanle Mary, Aworinde Juliana Oluwasayo   +10 more
doaj   +1 more source

In silico Molecular Docking Analysis Targeting SARSCoV-2 Spike Protein and Selected Herbal Constituents

Journal of Pure and Applied Microbiology, 2020
In modern drug discovery, molecular docking analysis is routinely used to understand and predict the interaction between a drug molecule and a target protein from a microbe.
Anbazhagan Subbaiyan, Karthikeyan Ravichandran, Shiv Varan Singh, Muthu Sankar, Prasad Thomas, Kuldeep Dhama, Yashpal S. Malik, Raj Kumar Singh, Pallab Chaudhuri   +8 more
doaj   +1 more source

Prediction of Flavin Mononucleotide (FMN) Binding Sites in Proteins Using the 3D Search Motif Method and Double-Centroid Reduced Representation of Protein 3D Structures [PDF]

arXiv, 2015
A pharmacophore consists of the parts of the structure of the ligand that are sufficient to express the biological and pharmacological effects of the ligand. It is usually a substructure of the entire structure of the ligand. Small organic molecules called ligands or metabolites in the cell form complexes with biomolecules (usually proteins) to serve ...
arxiv  

Identification of Class I HLA T Cell Control Epitopes for West Nile Virus [PDF]

, 2013
The recent West Nile virus (WNV) outbreak in the United States underscores the importance of understanding human immune responses to this pathogen.
A Harari, A Sette, A Wahl, AC Tan, B Custer, B Shrestha, BC Braun, BEE Martina, BF Haynes, Charles R. Rinaldo, CP McMurtrey, Curtis P. McMurtrey, D Weiskopf, Diana M. Campbell, EB Bell, F Mostashari, Fredda B. Schafer, HD Hickman, HL Robinson, HL Smith, HM Jackson, J Roelse, JW Yewdell, K Eneslatt, K Prilliman, Kenneth W. Jackson, KR Prilliman, L Rodriguez Mde, M De Filette, MG Duvall, MP Busch, MR Leach, MS Diamond, MS Diamond, MS Diamond, MS Leffell, MV Larsen, N Caccamo, P Piazza, PA Wearsch, Paolo A. Piazza, PM Kloetzel, R Buchli, Rico Buchli, RS Akondy, S Kim, Saghar Kaabinejadian, Stephen R. Vernon, Steven J. Cate, T Oliphant, Tian Wang, U Seifert, WG Glass, Wilfried Bardet, William H. Hildebrand, Y Lin, Y Wang   +56 more
core   +3 more sources