Results 151 to 160 of about 2,296,826 (424)
Human Cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against NK cell cytotoxicity. [PDF]
, 2003 The activating receptor, NKG2D, is expressed on a variety of immune effector cells and recognizes divergent families of major histocompatibility complex (MHC) class I-related ligands, including the MIC and ULBP proteins.
Chalupny, NJ +6 more
core
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source
Substituted 1,3,5-Triazine Hexacarboxylates as Potential Linkers for MOFs
Molecules, 2019 Hexacarboxylates are promising linkers for MOFs such as NU-109 or NU-110, which possess large values for surfaces and pore volumina. Starting from 2,4,6-tris(bromoaryl)-1,3,5-triazines, palladium-catalyzed cross coupling reactions (Suzuki-Miyaura ...
Arne Klinkebiel +2 more
doaj +1 more source
Change in flexibility of DNA with binding ligands [PDF]
arXiv, 2017 The percentage and sequence of AT and GC base pairs and charges on the DNA backbone contribute significantly to the stiffness of DNA. This elastic property of DNA also changes with small interacting ligands. The single-molecule force spectroscopy technique shows different interaction modes by measuring the mechanical properties of DNA bound with small ...
arxiv
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
NKG2D ligands mediate immunosurveillance of senescent cells
Aging, 2016 Cellular senescence is a stress response mechanism that limits tumorigenesis and tissue damage. Induction of cellular senescence commonly coincides with an immunogenic phenotype that promotes self-elimination by components of the immune system, thereby ...
Adi Sagiv +8 more
semanticscholar +1 more source
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
Ligand Substitution Dynamics [PDF]
, 1968 Cooper H. Langford, Thomas R. Stengle
openalex +2 more sources
Absorption Spectra of Coordination Compounds. V. The Hyperchromic Series of Ligands [PDF]
, 1953 Shoichiro Yamada, Ryutaro Tsuchida
openalex +1 more source