Results 151 to 160 of about 2,433,325 (381)

PROTAC Technology as a New Tool for Modern Pharmacotherapy

Molecules
The publication focuses on the innovative applications of PROTAC (proteolysis-targeting chimera) technology in modern pharmacotherapy, with particular emphasis on cancer treatment. PROTACs represent an advanced therapeutic strategy that enables selective
Natalia Kubryń, Łukasz Fijałkowski, Jacek Nowaczyk, Amer Jamil, Alicja Nowaczyk   +4 more
doaj   +1 more source

PD-1 and its ligands in tolerance and immunity.

Annual Review of Immunology, 2008
M. Keir, M. Butte, G. Freeman, A. Sharpe
semanticscholar   +1 more source

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco, Mònica Roldán, Yalda Jamshidi, Ioannis Georvasilis, Rocío Jadraque Rodríguez, Reza Boostani, Ali Shoeibi, Lluís Armengol, Anna Codina, Ehsan Ghayoor Karimiani, Cristina Hernando‐Davalillo, Loreto Martorell, María Luisa Ramírez Almaraz, Jordi Muchart, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Daniel Natera‐de Benito, Mercedes Serrano   +18 more
wiley   +1 more source

Study of wound-healing properties of humic substance – zinc complexes in the aseptic wound model in vivo

Бюллетень сибирской медицины
The aim was to investigate wound-healing properties of zinc-containing biocomposites based on humic ligands (humic substance (HS) – Zn) in the in vivo experiment on the aseptic wound model and to evaluate their resorptive properties.Materials and methods.
M. V. Zykova, V. V. Ivanov, K. S. Larionov, L. A. Azarkina, E. E. Buyko, K. A. Bratishko, A. A. Ufandeev, E. S. Rabtsevich, D. A. Mikhalev, I. S. Kopnov, I. V. Perminova, M. V. Belousov   +11 more
doaj   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Automated design of ligands to polypharmacological profiles

, 2012
Jérémy Besnard, G.F. Ruda, Vincent Setola, Keren Abecassis, Ramona M. Rodriguiz, Xi‐Ping Huang, Suzanne Norval, Maria F. Sassano, Antony I. Shin, Lauren Webster, Frederick R. C. Simeons, Laste Stojanovski, Annik Prat, Nabil G. Seidah, Daniel B. Constam, G. Richard Bickerton, Kevin D. Read, William C. Wetsel, Ian H. Gilbert, Bryan L. Roth, Andrew L. Hopkins   +20 more
openalex   +2 more sources

CXCR3/Ligands Are Significantly Involved in the Tumorigenesis of Basal Cell Carcinomas [PDF]

, 2010
Blanche K.K. Lo, Mei Yu, David Zloty, Bryce J. Cowan, Jerry Shapiro, Kevin J. McElwee   +5 more
openalex   +1 more source

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.

Proceedings of the National Academy of Sciences of the United States of America, 1998
M. Lambert, A. Barlow, B. Chromy, C. Edwards, R. Freed, M. Liosatos, Todd E. Morgan, I. Rozovsky, B. Trommer, K. Viola, P. Wals, Zhang Chi, C. Finch, G. Krafft, W. Klein   +14 more
semanticscholar   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Radical ligand transfer: a general strategy for radical functionalization [PDF]

, 2023
David Nemoto, Kang‐Jie Bian, Shih‐Chieh Kao, Julian G. West   +3 more
openalex   +1 more source