Results 101 to 110 of about 21,470 (214)

Sun1 deficiency leads to cerebellar ataxia in mice

Disease Models & Mechanisms, 2015
Migration and organization of the nucleus are essential for the proliferation and differentiation of cells, including neurons. However, the relationship between the positioning of the nucleus and cellular morphogenesis remains poorly understood ...
Jing-Ya Wang, I.-Shing Yu, Chien-Chi Huang, Chia-Yen Chen, Wan-Ping Wang, Shu-Wha Lin, Kuan-Teh Jeang, Ya-Hui Chi   +7 more
doaj   +1 more source

NPLOT: an Interactive Plotting Program for NASTRAN Finite Element Models [PDF]

, 1985
The NPLOT (NASTRAN Plot) is an interactive computer graphics program for plotting undeformed and deformed NASTRAN finite element models. Developed at NASA's Goddard Space Flight Center, the program provides flexible element selection and grid point, ASET
Jones, G. K., Mcentire, K. J.
core   +1 more source

Structural Basis of the Membrane Association by the Conserved RocS Membrane‐Targeting Sequence in Streptococcus

Advanced Science, EarlyView.
Chromosome segregation in Streptococcus pneumoniae depends on RocS, a bitopic protein whose membrane‐anchoring mechanisms were unclear. Using NMR and AFM, this study reveals that the widely conserved RocS anchor binds to membranes via a conserved kink‐helix motif which inserts into lipid nanodomains.
Ana Álvarez‐Mena, Estelle Morvan, Clara Lambert, Anagha Kallisseri Parambil, Martin Lefeuvre, Zeren Xu, Nadia El Mammeri, Florian Malard, Erick J. Dufourc, Cécile Feuillie, Christophe Grangeasse, Birgit Habenstein   +11 more
wiley   +1 more source

SUN-domain proteins of the malaria parasite Plasmodium falciparum are essential for proper nuclear division and DNA repair

mBio
The protozoan parasite Plasmodium falciparum, which is responsible for the deadliest form of human malaria, accounts for over half a million deaths a year.
Sofiya Kandelis-Shalev, Manish Goyal, Tal Elam, Shany Assaraf, Noa Dahan, Omer Farchi, Eduard Berenshtein, Ron Dzikowski   +7 more
doaj   +1 more source

Real‐Time Digital Micromotor Tracking‐Enabled Ultrasensitive Immunoassay

Advanced Science, EarlyView.
An AI‐facilitated real‐time digital micromotor tracking‐enabled immunoassay is developed, which leverages a self‐developed multi‐microparticle tracking system to monitor micromotor motion trajectories in a real‐time manner for digital protein analysis.
Jingjing Shi, Zuhua Yu, Hui Tian, Wenjiao Fan, Yuanyuan Sun, Wei Ren, Chenghui Liu   +6 more
wiley   +1 more source

Hierarchichal-segmented AO in order to attain wide field compensation in the visible on an 8m class telescope

, 2017
We describe the preliminary optimized layout for a partially optimized concept of an optical-8m class VLT-like 2x2 segmented camera where each channel is assisted by an equivalent of an MCAO system where the ground layer correction is commonly employed ...
Bergomi, Maria, Biondi, Federico, Chinellato, Simonetta, Dima, Marco, Falomo, Renato, Farinato, Jacopo, Greggio, Davide, Gullieuszik, Marco, Magrin, Demetrio, Marafatto, Luca, Ragazzoni, Roberto, Vassallo, Daniele, Viotto, Valentina   +12 more
core   +1 more source

Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol‐Induced Intestinal Injury via Microbiota‐Dependent and ‐Independent AHR Activation

Advanced Science, EarlyView.
Glucuronolactone (GLU) as a natural metabolite of glucose, increases Lactobacillus amylovorus abundance and luminal IAA level to activate AHR signaling. In addition, GLU itself can directly elevate AHR signaling activity independently of microbiota and IAA.
Chenbin Cui, Beibei Zhang, Jiaxi Tang, Jing Hou, Yueqin Qiu, Kaiguo Gao, Li Wang, Zongyong Jiang, Xuefen Yang   +8 more
wiley   +1 more source

Identifying essential components of a plant LINC complex

, 2018
The higher plant NE contains a functional Linker of Nucleoskeleton and Cytoskeleton (LINC) complex based on conserved Sad1-Unc84 (SUN) domain proteins and plant specific Klarsicht/Anc1/Syne homology (KASH) domain proteins (Figure 1). Recent evidence suggests the presence of a plant lamina underneath the inner membrane and various coiled-coil proteins ...
Poulet, Alex, Probst, Aline, Tatout, Christophe, Graumann, Katja, Evans, David E.   +4 more
openaire   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Advancing knowledge of the plant nuclear periphery and its application for crop science

Nucleus, 2020
In this review, we explore recent advances in knowledge of the structure and dynamics of the plant nuclear envelope. As a paradigm, we focused our attention on the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, a structurally conserved ...
David E. Evans, Sarah Mermet, Christophe Tatout   +2 more
doaj   +1 more source