Results 111 to 120 of about 8,120 (205)
, 2023 The LINC complex, consisting of interacting SUN and KASH proteins, mechanically couples nuclear contents to the cytoskeleton. In meiosis, the LINC complex transmits microtubule-generated forces to chromosome ends, driving the rapid chromosome movements ...
Owen R. Davies (6861560) +3 more
core +1 more source
The Journal of Pathology, EarlyView.Abstract The extracellular matrix (ECM) plays a pivotal role in facilitating tumour development, invasiveness, metastasis, and immunoevasive processes through dynamic ECM remodelling processes. Testican‐1 (SPOCK1), an excretory matricellular proteoglycan, is suggested to exert a role in the facilitation of ECM remodelling processes through interacting ...
Sepideh Youssefi +6 more
wiley +1 more source
SUN/KASH interactions facilitate force transmission across the nuclear envelope
Nucleus, 2019 LINC complexes (Linker of Nucleoskeleton and Cytoskeleton), consisting of inner nuclear membrane SUN (Sad1, UNC-84) proteins and outer nuclear membrane KASH (Klarsicht, ANC-1, and Syne Homology) proteins, are essential for nuclear positioning, cell ...
Hongyan Hao, Daniel A. Starr
doaj +1 more source
Characterization of LINC Complex-mediated Regulation of Satellite Stem and Progenitor Cell Cycles
, 2019 Emery-Dreifuss muscular dystrophy (EDMD) is an inherited disorder characterized by skeletal muscle wasting and cardiomyopathy. EDMD is linked to mutations affecting proteins forming the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex.
McKee-Muir, Olivia Charlotte
core
, 2023 Though cancer cells have been shown to have abnormal nuclear morphologies and responses to mechanical forces, the mechanisms of how mechanical stress is translated into cellular action and structural reorganization within the nuclear envelope are largely
Adams, Rebecca, Boecher, Dean
core
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi +12 more
wiley +1 more source
Nucleus, 2019 During meiosis, homologous chromosomes undergo a dramatic movement in order to correctly align. This is a critical meiotic event but the molecular properties of this ‘chromosomal dance’ still remainunclear.
Jana Rohožková +4 more
doaj +1 more source
Mutations in LMNA modulate the lamin A--Nesprin-2 interaction and cause LINC complex alterations.
PLoS ONE, 2013 BackgroundIn eukaryotes the genetic material is enclosed by a continuous membrane system, the nuclear envelope (NE). Along the NE specific proteins assemble to form meshworks and mutations in these proteins have been described in a group of human ...
Liu Yang +5 more
doaj +1 more source
Investigating the Role of the LINC Complex on Skeletal Muscle Stem and Progenitor Cell Expansion
, 2023 Muscle stem cells, or satellite cells (SCs), are required for skeletal muscle regeneration. Emery-Dreifuss muscular dystrophy (EDMD), a debilitating muscle disorder, is associated with LINC complex mutations, a series of nuclear envelope proteins ...
Gorospe, Kristyna Anatalia
core
LINC komplex: Spojník mezi integritou chromatinu a motilitou spermií [PDF]
, 2022 The LINC complex (Linker of the Nucleoskeleton and Cytoskeleton) is a protein structure located in the nuclear membrane that connects the cytoskeleton with the nucleoskeleton.
Šanovec, Ondřej
core