Cortisol Recognition by a Conformationally Responsive DNA Aptamer
Advanced Sensor Research, Volume 5, Issue 8, August 2026.The full‐length 85mer cortisol aptamer intrinsically populates two metastable conformational states in equilibrium. Cortisol binding redistributes the conformational ensemble by shifting the equilibrium between open and compact states while maintaining the underlying secondary structure. This ligand‐induced tertiary reorganization provides an atomistic
Lakshitha Jasin Arachchige +4 more
wiley +1 more source
Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex. [PDF]
J Mol Cell Biol, 2022 Zhang Y +5 more
europepmc +1 more source
Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy
Advanced Science, Volume 13, Issue 44, 7 August 2026.MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang +11 more
wiley +1 more source
Viscoelastic Mechanical Models of the LINC Complex
Biophysical Journal, 2020 Kamyar Behrouzi +2 more
openaire +1 more source
Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers
Advanced Science, Volume 13, Issue 44, 7 August 2026.Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang +5 more
wiley +1 more source
Backbone‐Length‐Optimized Inhibitors Deliver Long‐Retention Selectivity in Area‐Selective ALD of VO2
Advanced Science, Volume 13, Issue 45, 13 August 2026.Area‐selective VO2 ALD is found to depend critically on inhibitor backbone length, which governs physisorption, chemisorption stability, and packing efficiency in a coupled manner. An intermediate backbone‐length achieves the best long‐retention selectivity, establishing a chemically and geometrically grounded design principle for small‐molecule ...
Hae Lin Yang +9 more
wiley +1 more source
The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction. [PDF]
Commun Biol, 2022 Purushothaman D +13 more
europepmc +1 more source
Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction
Advanced Science, Volume 13, Issue 46, 17 August 2026.We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen +3 more
wiley +1 more source
In Vitro Synthesis and Reconstitution Using Mammalian Cell-Free Lysates Enables the Systematic Study of the Regulation of LINC Complex Assembly. [PDF]
Biochemistry, 2022 Majumder S +6 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 46, 17 August 2026.Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen +14 more
wiley +1 more source