Results 141 to 150 of about 7,490 (198)

Arabidopsis KASH domains are differentially required for distinct LINC complex roles in stomata, roots and pollen. [PDF]

J Cell Sci
Schumacher LA, Groves NR, Conway DE, Meier I.   +3 more
europepmc   +1 more source

What Makes the Best Educator? A Qualitative Analysis of Emergency Medicine Resident Perspectives

AEM Education and Training, Volume 10, Issue 4, August 2026.
ABSTRACT Background Effective clinical educators are essential to emergency medicine (EM) residency training, and the pace and dynamics of the emergency department require them to have a unique educational skillset. Most existing literature defining educational excellence in EM reflects educator rather than learner perspectives, and there is limited ...
Marshall Howell, Joshua Ginsburg, Erin Lincoln, C. Reece Brockman II, D. Mark Courtney, Brian Milman   +5 more
wiley   +1 more source

Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function. [PDF]

J Cell Sci
Lio C, Wang Y, Wilson PC, Li Y, Antoku S, Östlund C, Shin JY, Worman HJ, Chang W, Gundersen GG.   +9 more
europepmc   +1 more source

The Mechanobiology of Adipocyte Hypertrophy: Cytoskeletal Remodelling as a Driver of Insulin Resistance in Obesity

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Adipocyte hypertrophy poses an important mechanical challenge—adipocytes can increase in volume up to a thousand‐fold while still maintaining their structural integrity. Although lipid metabolism is well studied, little is known about the cytoskeletal adaptations that are required to accommodate this expansion and the resulting pathological ...
Dhakshmi Sasankan, Renu Mohan
wiley   +1 more source

The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in <i>S. pombe</i>. [PDF]

Genes Dev
Laffitte A, Lin D, Tian YJ, Liu N, Lusk CP, Mochrie SGJ, King MC.   +6 more
europepmc   +1 more source

The LINC complex ensures accurate centrosome positioning during prophase

, 2023
Lima JT, Pereira AJ, Ferreira JG.
europepmc   +1 more source

The LINC complex is required for endothelial cell adhesion and adaptation to shear stress and cyclic stretch. [PDF]

Mol Biol Cell, 2021
Denis KB, Cabe JI, Danielsson BE, Tieu KV, Mayer CR, Conway DE.   +5 more
europepmc   +1 more source

Structural and biochemical characterization of LINC complexes

, 2017
The nuclear envelope (NE) is comprised of a double membrane bilayer that physically separates the nucleoplasm from the cytoplasm. Information can be transmitted through the NE by molecular exchange through the nuclear pore complex (NPC) and by transduction of mechanical forces mediated by the linker of nucleoskeleton to cytoskeleton (LINC) complexes ...
openaire   +1 more source

Mapping the Distribution of Mechanical Stresses in the LINC Complex [PDF]

Biophysical Journal, 2020
Kamyar Behrouzi, Zeinab Jahed, Mohammad R. Mofrad   +2 more
openaire   +1 more source

Vorinostat Mitigates Early Brain Injury Following Subarachnoid Hemorrhage Through Modulation of the C3aR1/TGF‐β/Smad Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
C3aR1 mediates microglial activation after SAH in part through the TGF‐β/Smad signaling pathway. Vorinostat alleviates early brain injury after SAH by reducing C3aR1 levels. ABSTRACT Background Excessive microglial activation after subarachnoid hemorrhage (SAH) contributes to early brain injury (EBI) and poor clinical outcomes.
Chonghui Zhang, Yifan Xu, Junshan Wan, Jinpeng Wu, Chao Wang, Yugong Feng   +5 more
wiley   +1 more source