Results 121 to 130 of about 21,470 (214)

Covalent Immobilization of Laccase on Mesoporous Bismuth Silicate for High‐Performance Biodegradation of Contaminants

European Journal of Inorganic Chemistry, EarlyView.
Myceliophthora thermophila laccase covalently immobilized on bismuth silicate (BiSi‐ext) achieved synergistic adsorption–biodegradation of Tectilon Blue 4R‐01 and ibuprofen. The biocatalyst showed enhanced stability, reusability, and rapid pollutant removal via expanded active‐site accessibility, enabling efficient, eco‐friendly wastewater remediation.
Erick Paiva Cancella, Guilherme de Paula Guarnieri, Yuriy B. Lipisa, Fábio Rogério de Moraes, Adriano de Vasconcellos, Giselle Maria Maciel, José Geraldo Nery   +6 more
wiley   +1 more source

Data‐Driven Engineering of Thermostable Collagen‐Mimetic Peptoid Triple Helices

Macromolecular Rapid Communications, EarlyView.
Data‐driven active learning discovery of collagen‐mimetic peptoids capable of forming a thermostable collagen‐like triple helix using computational screening followed by experimental validation. ABSTRACT Collagen‐mimetic peptides (CMPs) are engineered molecules designed to replicate the triple‐helical structure of natural collagen.
Alex Berlaga, Renyu Zheng, Zeqian Zhang, Junhee Lee, Diya Gandhi, Chun‐Long Chen, Andrew L. Ferguson   +6 more
wiley   +1 more source

Computational Study on Potentially Active Antibacterial Compounds in Secondary Metabolites of Extremophilic Microorganisms

ChemistryOpen, EarlyView.
This study employed density functional theory (DFT) and conceptual DFT (CDFT) to calculate the structures and properties of potential antibacterial compounds derived from 16‐membered lactone ring‐containing secondary metabolites of extremophiles, as well as midecamycin.
Dilong Li, Yanni Wang, Yinhuan Huang, Hui Zhou, Xiaoyun Xia, Wei Huang, Chaojie Wang   +6 more
wiley   +1 more source

Blood glutamate EAAT2-cell grabbing therapy in cerebral ischemiaResearch in context

EBioMedicine, 2019
Background: Excitatory amino acid transporter 2 (EAAT2) plays a pivotal role in glutamate clearance in the adult brain, thereby preventing excitotoxic effects.
María Pérez-Mato, Ramón Iglesias-Rey, Alba Vieites-Prado, Antonio Dopico-López, Bárbara Argibay, Héctor Fernández-Susavila, Andrés da Silva-Candal, Amparo Pérez-Díaz, Clara Correa-Paz, Anne Günther, Paulo Ávila-Gómez, M. Isabel Loza, Arnd Baumann, José Castillo, Tomás Sobrino, Francisco Campos   +15 more
doaj   +1 more source

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Meiotic chromosome movement: what’s lamin got to do with it?

Nucleus, 2019
Active meiotic chromosome movements are a universally conserved feature. They occur at the early stages of prophase of the first meiotic division and support the chromosome pairing process by (1) efficiently installing the synaptonemal complex between ...
Dimitra Paouneskou, Verena Jantsch
doaj   +1 more source

Ligand‐Driven Optimization of Iron Oxide Nanoprobes for In Vivo MRI Enhancement at Ultra‐High Field

Small, EarlyView.
Ligand‐tailored iron oxide nanoparticles reveal how surface chemistry controls T2 relaxivity and in vivo performance in ultra‐high‐field MRI. Systematic variation of hydrophilicity and charge across five coatings modulated r2 by up to 333 mm−1 s−1, with chemical properties, rather than shell thickness, dictating magnetic dephasing and enabling reliable
Pelayo García‐Acevedo, María Luz Alonso‐Alonso, Sara Ortega‐Espina, Manuel Bañobre‐López, Yolanda Piñeiro, Ramón Iglesias‐Rey, José Rivas   +6 more
wiley   +1 more source

Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease

Nucleus
The vascular network, uniquely sensitive to mechanical changes, translates biophysical forces into biochemical signals for vessel function. This process relies on the cell's architectural integrity, enabling uniform responses to physical stimuli ...
Tung D. Nguyen, Michael A. Winek, Mihir K. Rao, Shaiva P. Dhyani, Monica Y. Lee   +4 more
doaj   +1 more source

Asymptotic Chow polystability in K\"ahler geometry [PDF]

, 2011
It is conjectured that the existence of constant scalar curvature K\"ahler metrics will be equivalent to K-stability, or K-polystability depending on terminology (Yau-Tian-Donaldson conjecture).
Futaki, Akito
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