Results 41 to 50 of about 75,839 (248)

Targeting the Notch1‐YY1‐ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8+ T‐Cell‐Driven Cancer Cell Pyroptosis

Advanced Science, EarlyView.
In hepatocellular carcinoma (HCC), aberrantly activated Notch1 signaling induces its target gene YY1, which impairs immunotherapy efficacy by suppressing tumor cell‐ICAM1‐driven T cell activation and the mediated pyroptosis of T cells against tumor cells.
Ke Zhu, Fa‐Peng Zhang, Chao Qin, Zhi‐Xiao Song, Cai‐Ni Yang, Shu‐Sheng Lin, Xian‐Huan Yu, Wen‐Rui Wu, Chao‐Qun Liu, Chao Liu, Lei‐Bo Xu   +10 more
wiley   +1 more source

Oil content and fatty acids composition of poppy seeds cultivated in two localities of Slovakia

Agriculture, 2016
Oil content, fatty acids profile, acid and saponification values of poppy seeds grown on two localities of the Slovak Republic were evaluated in the study.
Lančaričová Andrea, Havrlentová Michaela, Muchová Darina, Bednárová Adriána   +3 more
doaj   +1 more source

LONG-CHAIN POLYUNSATURATED FATTY ACIDS AND THEIR ROLE IN CHILDREN NOURISHMENT

Вопросы современной педиатрии, 2012
The article deals with the mechanisms of metabolism of linoleic and α-linoleic polyunsaturated fatty acids as precursors of long-chain polyunsaturated fatty acids — arachidonic (ω-6 family) and docosahexaenoic acid (ω-3 famyli).
T. E. Borovik, S. G. Gribakin, V. A. Skvortsova, N. N. Semenova, T. N. Stepanova, N. G. Zvonkova   +5 more
doaj   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Effect of a fat-free diet and of different dietary fatty acids (palmitate, oleate, and linoleate) on the fatty acid composition of fresh-water fish lipids

Journal of Lipid Research, 1963
When fresh-water fish Pimelodus maculatus were fed a fat-deficient diet, the concentration of linoleic and arachidonic acids in glycerides and phospholipids decreased, and the concentration of palmitic, palmitoleic, oleic, and eicosatrienoic acids ...
R.R. Brenner, D.V. Vazza, M.E. De Tomás
doaj   +1 more source

Creating Cell‐Based Hybrid Noodles for Sustainable and Nutrient‐Balanced Diets via a Serum‐Free and Animal‐Free 3D Co‐Differentiation System

Advanced Science, EarlyView.
This study develops a 3D co‐culture and co‐differentiation system for porcine muscle stem cells (pMuSCs) and mesenchymal stem cells (pMSCs) on edible starch‐based scaffolds. The system simultaneously generates myotubes and adipocytes without using serum or chemical inducers.
Xin Guan, Luyi Wang, Wanqiang Sun, Yiwei Feng, Dandan Wang, Haohao Tang, Zhenwu Ma, Guocheng Du, Jian Chen, Jingwen Zhou   +9 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

The Effect of Silk on the Stabilization of Labile Enzyme Lipoxygenase

Advanced NanoBiomed Research, EarlyView.
Entrapping lipoxygenase within silk significantly extended its stability from under 24 h to 10 days. Variations in silk molecular weight and freeze‐drying conditions influenced silk properties and enzyme interactions. This stabilization is leveraged to develop a linoleic acid electrochemical biosensor, integrating lipoxygenase with horseradish ...
Jacopo Giaretta, Xinyu (Vivian) Xie, Sandra Spoa, Hien A. Tran, Syamak Farajikhah, Sepehr Talebian, Jelena Rnjak‐Kovacina, Fariba Dehghani   +7 more
wiley   +1 more source

Metabolism of U13C-labeled linoleic acid in lactating women

Journal of Lipid Research, 1998
Long chain polyunsaturated fatty acids are nutritionally important constituents of breast milk. The origin of these fatty acids in milk has not been clearly identified.
H. Demmelmair, M. Baumheuer, B. Koletzko, K. Dokoupil, G. Kratl   +4 more
doaj   +1 more source

Brazil Nut Flour as a Functional Ingredient: Effects on Texture, Composition and Sensory Profile of Reduced‐Sugar Gluten‐Free Cookies

Journal of the American Oil Chemists' Society, EarlyView.
Graphical abstract of the characterization of Brazil nut flour (BNF) and the impact of its addition on the nutritional and sensory properties of gluten‐free and low‐sugar cookies. The results show that BNF contributed to an improved nutritional quality of the cookies and enhanced overall product acceptance.
Ana Luísa Schiessl Fabri, Lucas Lourenço dos Santos, Giustino Tribuzi, Pedro Luiz Manique Barrreto, Renata Dias de Mello Castanho Amboni, Maria Manuela Camino Feltes   +5 more
wiley   +1 more source