Results 1 to 10 of about 138,242 (203)
Porcine deltacoronavirus infection promotes intracellular lipid droplet accumulation [PDF]
Virology JournalBackground Viruses critically depend on host lipid metabolism to drive replication, assembly and immune evasion during infection and pathogenesis. While previous studies have demonstrated that certain viruses induce lipid droplet accumulation in infected
Xiaohui Yang +7 more
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Lipid droplet distribution quantification method based on lipid droplet detection by constrained reinforcement learning. [PDF]
PLoS ONEWe previously proposed the lipid droplet detection by reinforcement learning (LiDRL) method using a limited dataset of pathological images. The method automatically detects lipid droplets using reinforcement learning to optimize filter combinations based
Yoshitomi Harada +2 more
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C18ORF32 modulates lipid droplet secretion via secretory autophagy and restrains hepatic steatosis in vivo [PDF]
Cell Communication and SignalingBackground Lipid droplets (LDs) are essential for maintaining cellular homeostasis by storing excess lipids, but regulation of their cellular level is crucial to prevent lipotoxicity under normal conditions.
Abhishek Kumar +3 more
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Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson’s disease [PDF]
Journal of NeuroinflammationMicroglia-mediated neuroinflammation plays a crucial role in the progression of Parkinson’s disease (PD). Dysregulation of lipid droplet homeostasis is a significant factor affecting microglial inflammatory responses, but the mechanisms underlying lipid ...
Chunlei Han +17 more
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Trends in Cell Biology, 2021 All living organisms can make lipid droplets (LDs), intracellular oil-in-water droplets, surrounded by a phospholipid and protein monolayer. LDs are at the nexus of cellular lipid metabolism and function in diverse biological processes. During the past decade, multidisciplinary approaches have shed light on LD assembly steps from the endoplasmic ...
Thiam, Abdou Rachid, Ikonen, Elina
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Lipid droplet biogenesis [PDF]
Current Opinion in Cell Biology, 2014 Lipid droplets (LDs) are found in most cells, where they play central roles in energy and membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly understood process involving the formation of a monolayer bound organelle from a bilayer membrane.
Florian, Wilfling +3 more
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Lipid droplet metabolism [PDF]
Current Opinion in Clinical Nutrition and Metabolic Care, 2013 With the realization that lipid droplets are not merely inert fat storage organelles, but highly dynamic and actively involved in cellular lipid homeostasis, there has been an increased interest in lipid droplet biology. Recent studies have begun to unravel the roles that lipid dropletss play in cellular physiology and provide insights into the ...
Victor K, Khor +2 more
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Monoubiquitination of ancient ubiquitous protein 1 promotes lipid droplet clustering. [PDF]
PLoS ONE, 2013 Lipid droplets, the intracellular storage organelles for neutral lipids, exist in a wide range of sizes and of morphologically distinct organization, from loosely dispersed lipid droplets to tightly packed lipid droplet clusters.
Daniel Lohmann +5 more
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The Plant Cell, 2022 Abstract Membrane contact sites (MCSs) are interorganellar connections that allow for the direct exchange of molecules, such as lipids or Ca2+ between organelles, but can also serve to tether organelles at specific locations within cells.
Hannah Elisa Krawczyk +14 more
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STAR Protocols, 2022 Summary: Here, we present a protocol to construct artificial lipid droplets to study the binding affinity of lipid droplet-associated proteins. We provide procedures to construct adiposomes and prepare recombinant lipid droplet-associated proteins.
Zelun Zhi +5 more
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