Results 11 to 20 of about 1,416,231 (245)
Rotavirus-Induced Lipid Droplet Biogenesis Is Critical for Virus Replication
Frontiers in Physiology, 2022 A variety of pathogens, including viruses, bacteria and parasites, target cellular lipid droplets for their replication. Rotaviruses (RVs) infect the villous epithelium of the small intestine and are a major cause of acute gastroenteritis in infants and ...
Jeanette M. Criglar +3 more
doaj +2 more sources
Lipid Droplet Biogenesis [PDF]
Annual Review of Cell and Developmental Biology, 2017 Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo, converting cells to emulsions with LDs constituting the dispersed oil phase in the aqueous cytoplasm. Here we review our current view of LD biogenesis.
Tobias C, Walther +2 more
openaire +3 more sources
Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex
Nature Communications, 2021 Lipid droplet biogenesis is orchestrated by the conserved membrane protein Seipin via an unknown mechanism. Here, the authors use structural, biochemical and molecular dynamics simulation approaches to reveal the mechanism of lipid droplet formation by ...
Yoel A. Klug +6 more
doaj +2 more sources
eLife, 2019 The VPS13A gene is associated with the neurodegenerative disorder Chorea Acanthocytosis. It is unknown what the consequences are of impaired function of VPS13A at the subcellular level.
Wondwossen M Yeshaw +12 more
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Current Opinion in Cell Biology, 2019 Lipid droplets (LDs) store neutral lipids in their core as an energy source when nutrients are scarce. The center of an LD is hydrophobic, and hence it is surrounded by a phospholipid monolayer, unlike other organelles that have an aqueous interior and are bounded by a phospholipid bilayer.
C. L. Jackson
openaire +4 more sources
Lipid droplet biogenesis and functions in health and disease
Nature Reviews Endocrinology, 2023 Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being recognized for their versatility beyond energy storage. Advances uncovering the intricacies of their biogenesis and the diversity of their physiological and ...
Armella Zadoorian +2 more
semanticscholar +1 more source
Nature Communications, 2023 Mitochondria empower the liver to regulate lipid homeostasis by enabling fatty acid oxidation during starvation and lipogenesis during nutrient-rich conditions.
Noble Kumar Talari +6 more
semanticscholar +1 more source
Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism
Nature Cell Biology, 2023 Lipid droplets (LDs) are cellular organelles critical for lipid homeostasis, with intramyocyte LD accumulation implicated in metabolic disorder-associated heart diseases.
Lei Han +9 more
semanticscholar +1 more source
Cancer & Metabolism, 2022 Background Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, possesses characteristic alterations to multiple metabolic pathways, including the accumulation of cytosolic lipid droplets.
Timothy D. Klasson +6 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Multiple studies have implicated dozens of risk loci that may be associated with Alzheimer’s disease (AD), but common mechanisms underlying how they may contribute to disease onset or progression remain elusive.
M. Moulton +9 more
semanticscholar +1 more source