Results 21 to 30 of about 1,416,231 (245)
Advancement of science, 2022 Fusobacterium nucleatum is a critical microbe that contributes to colorectal cancer progression and chemoresistance. However, whether and how F. nucleatum regulates colorectal cancer stem‐like cells (CCSCs) remains unknown. Here, the authors show that F.
Haiyang Liu +8 more
semanticscholar +1 more source
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination
Journal of Experimental Medicine, 2021 Remyelination requires the clearance of cholesterol-rich myelin debris within demyelinating lesions by phagocytes. Gouna et al. found that TREM2-dependent formation of lipid droplets is necessary to buffer excess lipids released by myelin injury and ...
Garyfallia Gouna +7 more
semanticscholar +1 more source
Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]
, 2008 Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Silva, Liliana M. R. +8 more
core +2 more sources
Frontiers in Nutrition, 2022 Intermittent fasting is one of the most common clinical treatments for the obesity, a main risk factor of the metabolic syndrome which can lead to a variety of diseases.
Hongqiang Li +8 more
doaj +1 more source
Lipid Droplet Accumulation Promotes RPE Dysfunction
International Journal of Molecular Sciences, 2022 Non-exudative age-related macular degeneration (AMD) is an irreversibly progressive retinal degenerative disease characterized by dysfunction and loss of retinal pigment epithelium (RPE).
Tomohiro Yako +4 more
semanticscholar +1 more source
The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology
bioRxiv, 2021 Lipid droplets (LDs) are organelles of cellular lipid storage with fundamental roles in energy metabolism and cell membrane homeostasis. There has been an explosion of research into the biology of LDs, in part due to their relevance in diseases of lipid ...
Niklas Mejhert +16 more
semanticscholar +1 more source
Lipids in Health and Disease, 2021 Pancreatic cancer is the fourth leading cause of cancer deaths in the United States both in females and in males, and is projected to become the second deadliest cancer by 2030. The overall 5-year survival rate remains at around 10%.
R. Bai, A. Rebelo, J. Kleeff, Y. Sunami
semanticscholar +1 more source
Lipid droplet availability affects neural stem/progenitor cell metabolism and proliferation
Nature Communications, 2021 Neural stem/progenitor cells (NSPCs) generate new neurons throughout adulthood. However, the underlying regulatory processes are still not fully understood.
Mergim Ramosaj +7 more
semanticscholar +1 more source
Self-assembly of Tween 80 micelles as nanocargos for oregano and trans-cinnamaldehyde plant-derived compounds [PDF]
, 2020 The self-assembly of Tween 80 (T80) micelles loaded with plant-based oregano essential oil (OR) and trans-cinnamaldehyde (TCA) was studied. The effect of different factors, including the surfactant to oil ratio, the presence of sodium chloride, thermal ...
Claeys, Myriam +4 more
core +1 more source
Seipin forms a flexible cage at lipid droplet formation sites
Nature Structural & Molecular Biology, 2021 Lipid droplets (LDs) form in the endoplasmic reticulum by phase separation of neutral lipids. This process is facilitated by the seipin protein complex, which consists of a ring of seipin monomers, with a yet unclear function. Here, we report a structure
H. Arlt +11 more
semanticscholar +1 more source