Results 31 to 40 of about 139,767 (297)
The lipase cofactor CGI58 controls placental lipolysis
JCI Insight, 2023 In eutherians, the placenta plays a critical role in the uptake, storage, and metabolism of lipids. These processes govern the availability of fatty acids to the developing fetus, where inadequate supply has been associated with substandard fetal growth.
Jennifer Guerrero-Santoro +11 more
doaj +1 more source
Lipid droplets go nuclear [PDF]
Journal of Cell Biology, 2016 Lipid droplets (LDs) are sometimes found in the nucleus of some cells. In this issue, Ohsaki et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201507122) show that the nuclear membrane, promyelocytic leukemia bodies, and the protein PML-II play a role in nuclear LD formation, suggesting functional relationships between these structures.
Farese, Robert, Walther, Tobias
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Lipid droplet detection by the cavity perturbation method [PDF]
, 2011 There are currently no point-of-care diagnosis strategies available to indicate the presence of neoplasmic growth. This research aims to develop a novel diagnostic strategy based on detecting TAG accumulation in cells.
A I Al-Shamma'a +7 more
core +1 more source
Lipid Droplets and Cellular Lipid Metabolism [PDF]
Annual Review of Biochemistry, 2012 Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores metabolic energy and membrane components, making LDs hubs for lipid metabolism. In addition, LDs are implicated in a number of other cellular functions, ranging from protein storage ...
Tobias C, Walther, Robert V, Farese
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Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes. [PDF]
PLoS ONE, 2015 Lipid droplets are intracellular energy storage organelles composed of a hydrophobic core of neutral lipid, surrounded by a monolayer of phospholipid and a diverse array of proteins.
Joseph D Love +7 more
doaj +1 more source
Lipid Droplets in Neurodegenerative Disorders [PDF]
Frontiers in Neuroscience, 2020 Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to dynamic and functionally active organelles involved in a variety of cellular functions. Studies have now informed significant roles for LDs in cellular signaling, metabolic disease, and inflammation.
Brandon C. Farmer +4 more
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The Phospholipid:Diacylglycerol Acyltransferase Lro1 Is Responsible for Hepatitis C Virus Core-Induced Lipid Droplet Formation in a Yeast Model System. [PDF]
PLoS ONE, 2016 Chronic infection with the hepatitis C virus frequently induces steatosis, which is a significant risk factor for liver pathogenesis. Steatosis is characterized by the accumulation of lipid droplets in hepatocytes.
Shingo Iwasa +7 more
doaj +1 more source
Organellar Contacts of Milk Lipid Droplets
Contact, 2020 Milk-secreting epithelial cells of the mammary gland are functionally specialized for the synthesis and secretion of large quantities of neutral lipids, a major macronutrient in milk from most mammals.
Jenifer Monks +2 more
doaj +1 more source
Dynamics of Vesicle Formation from Lipid Droplet: Mechanism and Controllability
, 2009 A coarse-grained model developed by Marrink et al. [J. Phys. Chem. B 111, 7812 (2007)] is applied to investigate vesiculation of lipid [dipalmitoylphosphatidylcholine (DPPC)] droplets in water.
Helfrich W., Xuehao He, Zilu Wang
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Lipid Droplets in Cancer [PDF]
, 2020 AbstractLipid droplets have a unique structure among organelles consisting of a dense hydrophobic core of neutral lipids surrounded by a single layer of phospholipids decorated with various proteins. Often labeled merely as passive fat storage repositories, they in fact have a remarkably dynamic life cycle. Being formed within the endoplasmic reticulum
openaire +2 more sources