COPI complex is a regulator of lipid homeostasis.
PLoS Biology, 2008 Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and regulation, it is clear that members of the PAT (perilipin,
Mathias Beller +6 more
doaj +1 more source
Emulsion formation and stabilization by biomolecules: the leading role of cellulose [PDF]
, 2019 Emulsion stabilization by native cellulose has been mainly hampered because of its insolubility in water. Chemical modification is normally needed to obtain water-soluble cellulose derivatives.
Costa, C. +6 more
core +1 more source
Porcine SCD1 Regulates Lipid Droplet Number via CLSTN3B in PK15 Cells
AnimalsFat deposition plays a key role in determining porcine meat quality traits, with lipid droplets serving as critical organelles for lipid storage in adipose tissue. Inhibiting lipid droplet biogenesis disrupts the lipid storage capacity of adipocytes. The
Wenzhe Bai +7 more
doaj +1 more source
A new fluorescence-based method identifies protein phosphatases regulating lipid droplet metabolism.
PLoS ONE, 2010 In virtually every cell, neutral lipids are stored in cytoplasmic structures called lipid droplets (LDs) and also referred to as lipid bodies or lipid particles.
Bruno L Bozaquel-Morais +4 more
doaj +1 more source
Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis [PDF]
, 2015 This work was supported by a Merit Scholarship from the Islamic Development Bank (to M.M.U.T.), The Agency for Science, Technology and Research, Singapore (A*STAR) (M.F.M.S), the Medical Research Council (MRC) [NIRG GO800203 and Research Grant MR/L002620/
Edwardson, J Michael +4 more
core +2 more sources
Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells [PDF]
, 2017 Wolbachia are intracellular maternally inherited bacteria that can spread through insect populations and block virus transmission by mosquitoes, providing an important approach to dengue control.
Ant, Thomas H. +9 more
core +11 more sources
TFAP2 transcription factors are regulators of lipid droplet biogenesis
eLife, 2018 How trafficking pathways and organelle abundance adapt in response to metabolic and physiological changes is still mysterious, although a few transcriptional regulators of organellar biogenesis have been identified in recent years.
Cameron C Scott +3 more
doaj +1 more source
Lipid Droplets in Disease [PDF]
Cells, 2019 Lipid droplets (LDs) are a crucial part of lipid storage; thus, they are important players in a variety of diseases that are affected by lipid imbalances such as obesity, fatty liver disease, type 2 diabetes, Alzheimer’s disease, cardiovascular disease, and cancer [...]
openaire +3 more sources
Redox BiologyLipid droplet accumulation in microglia has been implicated in inflammatory functions associated with aging and demyelinating diseases. However, the molecular mechanisms driving lipid droplet formation under pathological conditions remain unrevealed.
Fengchen Zhang +9 more
doaj +1 more source
Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization [PDF]
, 2016 Scope: Obesity is closely related to the imbalance of white adipose tissue storing excess calories, and brown adipose tissue dissipating energy to produce heat in mammals.
Bao, Yong P. +10 more
core +1 more source