Results 41 to 50 of about 1,416,231 (245)
Reversible Nuclear-Lipid-Droplet Morphology Induced by Oleic Acid: A Link to Cellular-Lipid Metabolism [PDF]
, 2017 Neutral lipidsÐinvolved in many cellular processesÐare stored as lipid droplets (LD), thosemainly cytosolic (cLD) along with a small nuclear population (nLD).
Garcia, Margarita Maria +5 more
core +3 more sources
Lipid droplets and polyunsaturated fatty acid trafficking: Balancing life and death
Frontiers in Cell and Developmental Biology, 2023 Lipid droplets are fat storage organelles ubiquitously distributed across the eukaryotic kingdom. They have a central role in regulating lipid metabolism and undergo a dynamic turnover of biogenesis and breakdown to meet cellular requirements for fatty ...
Mauro Danielli +3 more
doaj +1 more source
Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. [PDF]
, 2017 Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt to energy demands under stress, whereas superfluous lipolysis causes metabolic disorders, including dyslipidemia and hepatic steatosis. Glucocorticoid-induced lipolysis requires the
Broughton, Augusta E +6 more
core +1 more source
Lipid droplets in stress protection: distinct mechanisms of lipid droplet microautophagy
Autophagy Reports, 2022 Lipid droplets (LDs) are organelles that function as sites for lipid storage. LDs have also been implicated in the cellular response to proteotoxic or lipotoxic stress as sites for sequestering dysfunctional or excess proteins or lipids, and targeting those cargos for degradation by LD microautophagy (microlipophagy, μLP).
Pin-Chao Liao, Liza A. Pon
openaire +3 more sources
The lipase cofactor CGI58 controls placental lipolysis
JCI Insight, 2023 In eutherians, the placenta plays a critical role in the uptake, storage, and metabolism of lipids. These processes govern the availability of fatty acids to the developing fetus, where inadequate supply has been associated with substandard fetal growth.
Jennifer Guerrero-Santoro +11 more
doaj +1 more source
Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes. [PDF]
PLoS ONE, 2015 Lipid droplets are intracellular energy storage organelles composed of a hydrophobic core of neutral lipid, surrounded by a monolayer of phospholipid and a diverse array of proteins.
Joseph D Love +7 more
doaj +1 more source
Lipid droplets go nuclear [PDF]
Journal of Cell Biology, 2016 Lipid droplets (LDs) are sometimes found in the nucleus of some cells. In this issue, Ohsaki et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201507122) show that the nuclear membrane, promyelocytic leukemia bodies, and the protein PML-II play a role in nuclear LD formation, suggesting functional relationships between these structures.
Farese, Robert, Walther, Tobias
openaire +3 more sources
Lipid droplet detection by the cavity perturbation method [PDF]
, 2011 There are currently no point-of-care diagnosis strategies available to indicate the presence of neoplasmic growth. This research aims to develop a novel diagnostic strategy based on detecting TAG accumulation in cells.
A I Al-Shamma'a +7 more
core +1 more source
Lipid Droplets and Cellular Lipid Metabolism [PDF]
Annual Review of Biochemistry, 2012 Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores metabolic energy and membrane components, making LDs hubs for lipid metabolism. In addition, LDs are implicated in a number of other cellular functions, ranging from protein storage ...
Tobias C, Walther, Robert V, Farese
openaire +2 more sources
Membrane Curvature Catalyzes Lipid Droplet Assembly
Current Biology, 2020 Lipid droplet (LD) biogenesis begins in the endoplasmic reticulum (ER) bilayer, but how the ER topology impacts this process is unclear. An early step in LD formation is nucleation, wherein free neutral lipids, mainly triacylglycerols (TGs) and sterol ...
Alexandre Santinho +7 more
semanticscholar +1 more source