Results 71 to 80 of about 139,767 (297)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites

Nature Communications
Membrane contact sites between organelles are critical for the transfer of biomolecules. Lipid droplets store fatty acids and form contacts with mitochondria, which regulate fatty acid oxidation and adenosine triphosphate production.
Ayenachew Bezawork-Geleta, Camille J. Devereux, Stacey N. Keenan, Jieqiong Lou, Ellie Cho, Shuai Nie, David P. De Souza, Vinod K. Narayana, Nicole A. Siddall, Carlos H. M. Rodrigues, Stephanie Portelli, Tenghao Zheng, Hieu T. Nim, Mirana Ramialison, Gary R. Hime, Garron T. Dodd, Elizabeth Hinde, David B. Ascher, David A. Stroud, Matthew J. Watt   +19 more
doaj   +1 more source

Optimized protocol for the identification of lipid droplet proteomes using proximity labeling proteomics in cultured human cells

STAR Protocols, 2021
Summary: Lipid droplets are endoplasmic reticulum-derived neutral lipid storage organelles that play critical roles in cellular lipid and energy homeostasis. Here, we present a protocol for the identification of high-confidence lipid droplet proteomes in
Clark W.H. Peterson, Kirandeep K. Deol, Milton To, James A. Olzmann   +3 more
doaj   +1 more source

A transient solution for vesicle electrodeformation and relaxation

, 2012
A transient analysis for vesicle deformation under DC electric fields is developed. The theory extends from a droplet model, with the additional consideration of a lipid membrane separating two fluids of arbitrary properties.
Lin, Hao, Tan, Wenchang, Zahn, Jeffery D., Zhang, Jia   +3 more
core   +1 more source

A new way of valorizing biomaterials: the use of sunflower protein for 1 a-tocopherol microencapsulation [PDF]

, 2013
Biopolymer based microparticles were efficiently prepared from sunflower protein (SP) wall material and a-tocopherol (T) active core using a spray-drying technique. Protein enzymatic hydrolysis and/or N-acylation were carried out to make some structural
A. Nesterenko, Aider, Augustin, Avaltroni, Benita, Burkus, Chabanon, Chanamai, Charve, Church, Daqiq, De Graaf, Dickinson, Dubey, Elizondo, F. Silvestre, F. Violleau, Faria, Favaro-Trindade, Fennema, Gharsallaoui, Glantz, Gonzalez-Perez, Gonzalez-Perez, Gonzalez-Perez, Goodno, Gouin, Guyomarc'h, I. Alric, Junyaprasert, Kang, Kawakatsu, Kong, Lamsal, Luo, Martinez, Matemu, Mo, Molina, Nesterenko, Nesterenko, Nunes, Ortiz, Patino, Pickardt, Pierucci, Rampon, Rascon, Rbii, Reiffers-Magnani, Robins, Rondel, Rusli, Salgado, V. Durrieu, Vastag, Vilkhu, Wang, Wong, Yohannes, Yoo, Yu, Yust, Zheng, Zorba   +64 more
core   +4 more sources

The lipid droplet lipidome

FEBS Letters
Lipid droplets (LDs) are intracellular organelles with a hydrophobic core formed by neutral lipids surrounded by a phospholipid monolayer harboring a variety of regulatory and enzymatically active proteins. Over the last few decades, our understanding of LD biology has evolved significantly.
Michele Wölk, Maria Fedorova
openaire   +2 more sources

Computational Studies of Lipid Droplets

The Journal of Physical Chemistry B, 2022
Lipid droplets (LDs) are intracellular organelles whose primary function is energy storage. Known to emerge from the endoplasmic reticulum (ER) bilayer, LDs have a unique structure with a core consisting of neutral lipids, triacylglycerol (TG) or sterol esters (SE), surrounded by a phospholipid (PL) monolayer and decorated by proteins that come and go ...
Siyoung Kim, Jessica M. J. Swanson, Gregory A. Voth   +2 more
openaire   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases

Cell & Bioscience, 2022
The importance of neuroglia in maintaining normal brain function under physiological and pathological conditions has been supported by growing evidence in recent years.
Danying Yang, Xifeng Wang, Lieliang Zhang, Yang Fang, Qingcui Zheng, Xing Liu, Wen Yu, Shoulin Chen, Jun Ying, Fuzhou Hua   +9 more
doaj   +1 more source

A finite membrane element formulation for surfactants

, 2019
Surfactants play an important role in various physiological and biomechanical applications. An example is the respiratory system, where pulmonary surfactants facilitate the breathing and reduce the possibility of airway blocking by lowering the surface ...
Roohbakhshan, Farshad, Sauer, Roger A.
core   +1 more source