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Preparation and Negative Staining for Visualization of Cyanoglobule Lipid Droplets Using Transmission Electron Microscopy [PDF]
Bio-ProtocolLipid droplets have emerged as dynamic organelles involved in diverse cellular processes beyond simple lipid storage. In plants and cyanobacteria, growing evidence highlights their importance in stress adaptation and signaling, yet methods to study their
Febri Susanto +2 more
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Lipid Droplets in Disease [PDF]
Cells, 2019 Lipid droplets (LDs) are a crucial part of lipid storage; thus, they are important players in a variety of diseases that are affected by lipid imbalances such as obesity, fatty liver disease, type 2 diabetes, Alzheimer’s disease, cardiovascular ...
Paul Dalhaimer
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Trends in Cell Biology, 2021 All living organisms can make lipid droplets (LDs), intracellular oil-in-water droplets, surrounded by a phospholipid and protein monolayer. LDs are at the nexus of cellular lipid metabolism and function in diverse biological processes. During the past decade, multidisciplinary approaches have shed light on LD assembly steps from the endoplasmic ...
Thiam, Abdou Rachid, Ikonen, Elina
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Volumetric analysis of lymphocyte lipid droplets in type 2 diabetes mellitus patients with hyperlipidemia [PDF]
Medicinski Podmladak, 2023 Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by inadequate glucose homeostasis. A common occurrence of T2DM is diabetic dyslipidemia.
Živković Aleksa +4 more
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Lipid droplet biogenesis [PDF]
Current Opinion in Cell Biology, 2014 Lipid droplets (LDs) are found in most cells, where they play central roles in energy and membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly understood process involving the formation of a monolayer bound organelle from a bilayer membrane.
Florian, Wilfling +3 more
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Small GTPase Rab40c associates with lipid droplets and modulates the biogenesis of lipid droplets. [PDF]
PLoS ONE, 2013 The subcellular location and cell biological function of small GTPase Rab40c in mammalian cells have not been investigated in detail. In this study, we demonstrated that the exogenously expressed GFP-Rab40c associates with lipid droplets marked by ...
Ran Tan +10 more
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Lipid droplet metabolism [PDF]
Current Opinion in Clinical Nutrition and Metabolic Care, 2013 With the realization that lipid droplets are not merely inert fat storage organelles, but highly dynamic and actively involved in cellular lipid homeostasis, there has been an increased interest in lipid droplet biology. Recent studies have begun to unravel the roles that lipid dropletss play in cellular physiology and provide insights into the ...
Victor K, Khor +2 more
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STAR Protocols, 2022 Summary: Here, we present a protocol to construct artificial lipid droplets to study the binding affinity of lipid droplet-associated proteins. We provide procedures to construct adiposomes and prepare recombinant lipid droplet-associated proteins.
Zelun Zhi +5 more
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The Plant Cell, 2022 Abstract Membrane contact sites (MCSs) are interorganellar connections that allow for the direct exchange of molecules, such as lipids or Ca2+ between organelles, but can also serve to tether organelles at specific locations within cells.
Hannah Elisa Krawczyk +14 more
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Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans.
PLoS Genetics, 2021 Fat stored in the form of lipid droplets has long been considered a defining characteristic of cytoplasm. However, recent studies have shown that nuclear lipid droplets occur in multiple cells and tissues, including in human patients with fatty liver ...
Jose Verdezoto Mosquera +2 more
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