Results 21 to 30 of about 1,446,619 (399)
Lipid droplets in the nervous system
Journal of Cell Biology, 2021 Ralhan et al. review the emerging role of lipid droplets in the nervous system in development, aging, and disease.
Isha Ralhan +3 more
semanticscholar +1 more source
Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans.
PLoS Genetics, 2021 Fat stored in the form of lipid droplets has long been considered a defining characteristic of cytoplasm. However, recent studies have shown that nuclear lipid droplets occur in multiple cells and tissues, including in human patients with fatty liver ...
Jose Verdezoto Mosquera +2 more
doaj +1 more source
Lipid Droplet Biogenesis [PDF]
Annual Review of Cell and Developmental Biology, 2017 Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo, converting cells to emulsions with LDs constituting the dispersed oil phase in the aqueous cytoplasm. Here we review our current view of LD biogenesis.
Tobias C, Walther +2 more
openaire +2 more sources
Degradation of lipid droplets by chimeric autophagy-tethering compounds
Cell Research, 2021 Degrading pathogenic proteins by degrader technologies such as PROTACs (proteolysis-targeting chimeras) provides promising therapeutic strategies, but selective degradation of non-protein pathogenic biomolecules has been challenging. Here, we demonstrate
Yuhua Fu +5 more
semanticscholar +1 more source
Lipid storage and autophagy in melanoma cancer cells [PDF]
, 2017 Cancer stem cells (CSC) represent a key cellular subpopulation controlling biological features such as cancer progression in all cancer types. By using melanospheres established from human melanoma patients, we compared less differentiated melanosphere ...
Cordella, Martina +9 more
core +5 more sources
Molecular Neurodegeneration, 2021 Background Disease-associated microglia (DAMs), that surround beta-amyloid plaques, represent a transcriptionally-distinct microglial profile in Alzheimer’s disease (AD). Activation of DAMs is dependent on triggering receptor expressed on myeloid cells 2
Christel Claes +10 more
semanticscholar +1 more source
Lipid Droplets: Packing Hydrophobic Molecules Within the Aqueous Cytoplasm.
Annual Review of Plant Biology, 2022 Lipid droplets, also known as oil bodies or lipid bodies, are plant organelles that compartmentalize neutral lipids as a hydrophobic matrix covered by proteins embedded in a phospholipid monolayer. Some of these proteins have been known for decades, such
Athanas Guzha +3 more
semanticscholar +1 more source
The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective
Biomolecules, 2023 It is widely accepted that nine hallmarks—including mitochondrial dysfunction, epigenetic alterations, and loss of proteostasis—exist that describe the cellular aging process.
Nikolaus Bresgen +4 more
doaj +1 more source
The autophagy protein ATG9A enables lipid mobilization from lipid droplets
Nature Communications, 2021 The multispanning membrane protein ATG9A is a scramblase that flips phospholipids between the two membrane leaflets, thus contributing to the expansion of the phagophore membrane in the early stages of autophagy.
Elodie Mailler +8 more
semanticscholar +1 more source
Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]
, 2008 Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Silva, Liliana M. R. +8 more
core +2 more sources