Results 11 to 20 of about 1,515,713 (252)

Ferroptosis: Mechanism and connections with cutaneous diseases

Frontiers in Cell and Developmental Biology, 2023
Ferroptosis is a recognized novel form of programmed cell death pathway, featuring abnormalities in iron metabolism, SystemXc−/glutathione axis, and lipid peroxidation regulation.
Lihao Liu, Ni Lian, Liqing Shi, Zhimin Hao, Kun Chen   +4 more
doaj   +1 more source

The interaction between ferroptosis and lipid metabolism in cancer

Signal Transduction and Targeted Therapy, 2020
Ferroptosis is a new form of programmed cell death characterized by the accumulation of iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that occur in lipid metabolism during ferroptosis and have provided intriguing ...
Dingshan Li, Yongsheng Li
semanticscholar   +1 more source

Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3

Cancer Science, 2017
In cancer cells the small compounds erastin and RSL3 promote a novel type of cell death called ferroptosis, which requires iron‐dependent accumulation of lipid reactive oxygen species.
Ryosuke Shintoku, Yuta Takigawa, Keiichi Yamada, Chisato Kubota, Y. Yoshimoto, T. Takeuchi, I. Koshiishi, S. Torii   +7 more
semanticscholar   +1 more source

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Redox Biology, 2019
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the cellular antioxidant response, controlling the expression of genes that counteract oxidative and electrophilic stresses.
M. Dodson, Raul Castro-Portuguez, Donna D. Zhang   +2 more
semanticscholar   +1 more source

Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review

Frontiers in Physiology, 2019
Ferroptosis is a newly identified form of nonapoptotic regulated cell death (RCD) characterized by iron-dependent accumulation of lipid peroxides. It is morphologically and biochemically different from known types of cell death. Ferroptosis plays a vital
Pengxu Lei, Tao Bai, Yuling Sun
doaj   +1 more source

Oral supplementation with organically modified clinoptilolite during prepartum period influences the redox status of peripheral blood and colostrum of primiparous dairy cows

Italian Journal of Animal Science, 2022
Redox imbalance in peripartum period influences health of dairy cows and their foetus and, through the colostrum, health of new-born calves. Oxidative stress in cattle can be suppressed by dietary supplementation with natural minerals, and we ...
Ivana Drvenica, Milica Stojić, Natalija Fratrić, Marijana Kovačić, Jelica Grujić-Milanović, Branislav Vejnović, Dragana Marković, Dragan Gvozdić, Vesna Ilić   +8 more
doaj   +1 more source

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Nature, 2017
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness. A high-mesenchymal cell state observed in human tumours and cancer cell lines has been associated with ...
V. Viswanathan, M. Ryan, Harshil Dhruv, S. Gill, Ossia M. Eichhoff, Brinton Seashore-Ludlow, S. Kaffenberger, J. Eaton, K. Shimada, A. Aguirre, S. Viswanathan, S. Chattopadhyay, P. Tamayo, W. Yang, M. Rees, Sixun Chen, Z. Boskovic, Sarah Javaid, Cherrie Huang, Xiaoyun Wu, Yuen-Yi Tseng, E. Roider, D. Gao, J. Cleary, B. Wolpin, J. Mesirov, D. Haber, J. Engelman, J. Boehm, J. Kotz, C. Hon, Yu Chen, W. Hahn, M. Levesque, John G Doench, M. Berens, Alykhan F. Shamji, P. Clemons, B. Stockwell, S. Schreiber   +39 more
semanticscholar   +1 more source

A Modified d-ROMs Method for Determination of Lipid Peroxidation [PDF]

Journal of Stress Physiology & Biochemistry, 2022
The need for simple and low costing and less time consuming methods for the determination of lipid peroxides and oxidative stress is urgent because oxidative stress is still unable to become a routine laboratory biomarker due to the sophisticated ...
Muammar A Y Nassar, Saleh H Sharif, Khalda M A Hammad   +2 more
doaj  

Ferroptosis-associated gene SLC7A11 is upregulated in NSCLC and correlated with patient’s poor prognosis: An integrated bioinformatics analysis

Pteridines, 2021
Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, which was involved in the progression of malignant tumors including non-small cell lung cancer (NSCLC).
Huang He, Liu Juan, Wu Haiyan, Liu Fang, Zhou Xiaoxi   +4 more
doaj   +1 more source

Lipid peroxidation in cell death

Biochemical and Biophysical Research Communications - BBRC, 2017
Disruption of redox homeostasis is a key phenotype of many pathological conditions. Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized as mediators and inducers of oxidative stress, increasingly, attention is focused on ...
M. Gaschler, B. Stockwell
semanticscholar   +1 more source