Results 41 to 50 of about 57,019 (310)

HCMV infection downregulates GPX4 and stimulates lipid peroxidation but does not induce ferroptosis

Journal of Virology
Human cytomegalovirus (HCMV) modulates numerous cellular pathways to facilitate infection, including key components in cellular iron homeostasis.
Madison Martin, Rinki Kumar, Nicholas J. Buchkovich, Christopher C. Norbury   +3 more
doaj   +1 more source

Antioxidant status in breast cancer patients of different ages after radiotherapy [PDF]

Archives of Biological Sciences, 2009
In this study we investigated the effects of breast cancer radiotherapy on the antioxidant (AO) enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), as well as on ...
Kasapović Jelena, Pejić Snežana, Todorović Ana, Stojiljković Vesna, Radošević-Jelić Ljiljana, Pajović Snežana B.   +5 more
doaj   +1 more source

Preventive Effects of Resveratrol against Beta Adrenergic Catecholamine-Induced Acute Myocardial Stress during Experimental Hyperglycemia in in Vivo and in Vitro Models [PDF]

, 2016
Aim: To evaluate the cardioprotective effects of resveratrol during hyperglycemic conditions in in vitro and in vivo models. Study Design: H9c2 cardiomyocyte cells were used as in vitro models and adult male Wistar strain albino rats were used as in vivo
Sreepriya, M., Uma, S.
core   +1 more source

Beneficial Impact of an Extract from the Berries of Aronia melanocarpa L. on the Oxidative-Reductive Status of the Submandibular Gland of Rats Exposed to Cadmium

Antioxidants, 2020
Oxidative stress underlies the pathomechanisms of toxic action of cadmium (Cd), including its damaging impact on the oral cavity. This study investigated whether the administration of an extract from Aronia melanocarpa L.
Adam Dąbrowski, Barbara M. Onopiuk, Halina Car, Paweł Onopiuk, Zofia N. Dąbrowska, Joanna Rogalska, Małgorzata M. Brzóska, Ewa Dąbrowska   +7 more
doaj   +1 more source

Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila [PDF]

, 2008
Apolipoprotein D (ApoD) expression increases in several neurological disorders and in spinal cord injury. We provide a report of a physiological role for human ApoD (hApoD): Flies overexpressing hApoD are long-lived and protected against stress ...
Ahn, Boyles, Boyles, Butterfield, D. W. Walker, Desai, Do Carmo, Duffy, Guti  rrez, J. Muffat, Kalman, Lechner, Morais Cabral, Navarro, Oakley, Pfaffl, Provost, Provost, Rassart, S. Benzer, Sanchez, Sutcliffe, Terrisse, Thomas, Thomas, Toroser, Vogt, Walker, Wallace, Walsh, Weech   +30 more
core   +3 more sources

The Role of Peroxiredoxins in the Regulation of Sepsis

Antioxidants, 2022
Oxidative stress, a result of a disturbance in redox homeostasis, is considered to be one of the main aggravating events in the pathogenesis of immune disorders.
Toshihiko Aki, Kana Unuma, Koichi Uemura
doaj   +1 more source

The role of non-coding RNA in ferroptosis of liver cancer and its impact on lipid peroxidation

Frontiers in Immunology
Ferroptosis is an iron-dependent programmed death caused by the imbalance of lipid peroxides in cells. Unlike apoptosis, autophagy and necrosis, ferroptosis is mainly induced by the small molecule compound erastin. The main characteristics of ferroptosis
Minglu Ding, Keyuan Huo, Xiaojie Chen, Wanyao Wang, Zihan Xiang, Yidan Song, Peijian Chen, Lantao Liu   +7 more
doaj   +1 more source

Protective Role of S-Adenosylmethionine Against Fructose-Induced Oxidative Damage in Obesity [PDF]

, 2017
Introduction. It has been shown that S-adenosylmethionine (S-AMe) stimulates glutathione synthesis and increases cell resistance to the cytotoxic action of free radicals and pro-inflammatory cytokines. The aim of this study was to determine the effect of
Bratoeva, Kameliya Zh, Donev, Ivan S, Merdzhanova, Albena V, Radanova, Mariya A   +3 more
core   +4 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Unveiling an unexpected superoxide-mediated photooxidation mechanism of squalene monohydroperoxides to squalene hydroperoxy cyclic peroxides through ESR and LC–MS/MS analyses

Scientific Reports, 2023
Lipid cyclic peroxides are a rarely reported and documented class of compounds in the human organism. Recently, we reported the formation of squalene (SQ) hydroperoxy cyclic peroxides derived from SQ monohydroperoxide isomers (SQ-OOHs) for the first time.
Saoussane Khalifa, Masaru Enomoto, Kiyotaka Nakagawa   +2 more
doaj   +1 more source