Results 31 to 40 of about 6,052,075 (348)

Solution NMR Structure of the SH3 Domain of Human Caskin1 Validates the Lack of a Typical Peptide Binding Groove and Supports a Role in Lipid Mediator Binding

Cells, 2021
SH3 domains constitute an important class of protein modules involved in a variety of cellular functions. They participate in protein-protein interactions via their canonical ligand binding interfaces composed of several evolutionarily conserved aromatic
Orsolya Tőke, Kitti Koprivanacz, László Radnai, Balázs Merő, Tünde Juhász, Károly Liliom, László Buday   +6 more
doaj   +1 more source

LPAAT3 incorporates docosahexaenoic acid into skeletal muscle cell membranes and is upregulated by PPARδ activation

Journal of Lipid Research, 2018
Adaption of skeletal muscle to endurance exercise includes PPARδ- and AMP-activated protein kinase (AMPK)/PPARγ coactivator 1α-mediated transcriptional responses that result in increased oxidative capacity and conversion of glycolytic to more oxidative ...
William J. Valentine, Suzumi M. Tokuoka, Daisuke Hishikawa, Yoshihiro Kita, Hideo Shindou, Takao Shimizu   +5 more
doaj   +1 more source

Plasmalogens and Photooxidative Stress Signaling in Myxobacteria, and How it Unmasked CarF/TMEM189 as the Δ1′-Desaturase PEDS1 for Human Plasmalogen Biosynthesis

Frontiers in Cell and Developmental Biology, 2022
Plasmalogens are glycerophospholipids with a hallmark sn-1 vinyl ether bond that endows them with unique physical-chemical properties. They have proposed biological roles in membrane organization, fluidity, signaling, and antioxidative functions, and ...
S. Padmanabhan, Antonio J. Monera-Girona, Elena Pajares-Martínez, Eva Bastida-Martínez, Irene del Rey Navalón, Ricardo Pérez-Castaño, María Luisa Galbis-Martínez, Marta Fontes, Montserrat Elías-Arnanz   +8 more
doaj   +1 more source

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Oxidative Medicine and Cellular Longevity, 2014
Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs).
A. Ayala, Mario F. Muñoz, S. Argüelles
semanticscholar   +1 more source

A novel phosphoglycerol serine-glycine lipodipeptide of Porphyromonas gingivalis is a TLR2 ligand

Journal of Lipid Research, 2020
Porphyromonas gingivalis is a Gram-negative anaerobic periodontal microorganism strongly associated with tissue-destructive processes in human periodontitis. Following oral infection with P.
Frank C. Nichols, Robert B. Clark, Mark W. Maciejewski, Anthony A. Provatas, Jeremy L. Balsbaugh, Floyd E. Dewhirst, Michael B. Smith, Amanda Rahmlow   +7 more
doaj   +1 more source

Comparative Analysis of Phospholipase D (PLD) Gene Family in Camelina sativa and Brassica napus and Its Responses in Camelina Seedlings under Salt Stress

Agronomy, 2023
Phospholipases are among the important elements involved in lipid-dependent cell signaling that lead to the induction of downstream pathways. In the current study, phospholipases D (PLDs) gene family was characterized and compared in two important ...
Parviz Heidari, Fatemeh Puresmaeli, Yavar Vafaee, Mostafa Ahmadizadeh, Mohammadreza Ensani, Haniyeh Ahmadinia   +5 more
doaj   +1 more source

Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

eLife, 2015
Polyunsaturated fatty acids (PUFAs) in phospholipids affect the physical properties of membranes, but it is unclear which biological processes are influenced by their regulation. For example, the functions of membrane arachidonate that are independent of
Tomomi Hashidate-Yoshida, Takeshi Harayama, Daisuke Hishikawa, Ryo Morimoto, Fumie Hamano, Suzumi M Tokuoka, Miki Eto, Miwa Tamura-Nakano, Rieko Yanobu-Takanashi, Yoshiko Mukumoto, Hiroshi Kiyonari, Tadashi Okamura, Yoshihiro Kita, Hideo Shindou, Takao Shimizu   +14 more
doaj   +1 more source

Establishment of LC-MS methods for the analysis of palmitoylated surfactant proteins[S]

Journal of Lipid Research, 2015
The surfactant proteins (SPs), SP-B and SP-C, are important components of pulmonary surfactant involved in the reduction of alveolar surface tension. Quantification of SP-B and SP-C in surfactant drugs is informative for their quality control and the ...
Takeshi Harayama, Hideo Shindou, Yoshihiro Kita, Eiji Otsubo, Kazushige Ikeda, Shoichi Chida, Timothy E. Weaver, Takao Shimizu   +7 more
doaj   +1 more source

Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2[S]

Journal of Lipid Research, 2014
Platelet-activating factor (PAF) is a potent pro-inflammatory phospholipid mediator. In response to extracellular stimuli, PAF is rapidly biosynthesized by lyso-PAF acetyltransferase (lyso-PAFAT).
Megumi Tarui, Hideo Shindou, Kazuo Kumagai, Ryo Morimoto, Takeshi Harayama, Tomomi Hashidate, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Takahide Nagase, Takao Shimizu   +10 more
doaj   +1 more source

Recent Advances in Research on Molecular Mechanisms of Fungal Signaling

Encyclopedia, 2022
Biochemical signaling is one of the key mechanisms to coordinate a living organism in all aspects of its life. It is still enigmatic how exactly cells and organisms deal with environmental signals and irritations precisely because of the limited number ...
Stefan Jacob, Sri Bühring, Katharina Bersching   +2 more
doaj   +1 more source