Results 31 to 40 of about 6,252,566 (347)

Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine

Frontiers in Molecular Neuroscience, 2021
BackgroundLipids are a primary storage form of energy and the source of inflammatory and pain signaling molecules, yet knowledge of their importance in chronic migraine (CM) pathology is incomplete.
Katherine Castor, Jessica Dawlaty, Xianghong Arakaki, Xianghong Arakaki, Noah Gross, Yohannes W. Woldeamanuel, Michael G. Harrington, Michael G. Harrington, Michael G. Harrington, Robert P. Cowan, Alfred N. Fonteh, Alfred N. Fonteh   +11 more
doaj   +1 more source

LPAAT3 incorporates docosahexaenoic acid into skeletal muscle cell membranes and is upregulated by PPARδ activation

Journal of Lipid Research, 2018
Adaption of skeletal muscle to endurance exercise includes PPARδ- and AMP-activated protein kinase (AMPK)/PPARγ coactivator 1α-mediated transcriptional responses that result in increased oxidative capacity and conversion of glycolytic to more oxidative ...
William J. Valentine, Suzumi M. Tokuoka, Daisuke Hishikawa, Yoshihiro Kita, Hideo Shindou, Takao Shimizu   +5 more
doaj   +1 more source

Chitosan Induces Plant Hormones and Defenses in Tomato Root Exudates

Frontiers in Plant Science, 2020
In this work, we use electrophysiological and metabolomic tools to determine the role of chitosan as plant defense elicitor in soil for preventing or manage root pests and diseases sustainably.
Marta Suarez-Fernandez, Marta Suarez-Fernandez, Frutos Carlos Marhuenda-Egea, Federico Lopez-Moya, Marino B. Arnao, Francisca Cabrera-Escribano, Maria Jose Nueda, Benet Gunsé, Luis Vicente Lopez-Llorca, Luis Vicente Lopez-Llorca   +9 more
doaj   +1 more source

A novel phosphoglycerol serine-glycine lipodipeptide of Porphyromonas gingivalis is a TLR2 ligand

Journal of Lipid Research, 2020
Porphyromonas gingivalis is a Gram-negative anaerobic periodontal microorganism strongly associated with tissue-destructive processes in human periodontitis. Following oral infection with P.
Frank C. Nichols, Robert B. Clark, Mark W. Maciejewski, Anthony A. Provatas, Jeremy L. Balsbaugh, Floyd E. Dewhirst, Michael B. Smith, Amanda Rahmlow   +7 more
doaj   +1 more source

Roles of Palmitoleic Acid and Its Positional Isomers, Hypogeic and Sapienic Acids, in Inflammation, Metabolic Diseases and Cancer

Cells, 2022
In the last few years, the monounsaturated hexadecenoic fatty acids are being increasingly considered as biomarkers of health with key functions in physiology and pathophysiology.
Miguel A. Bermúdez, Laura Pereira, Cristina Fraile, Laura Valerio, María A. Balboa, Jesús Balsinde   +5 more
doaj   +1 more source

Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

eLife, 2015
Polyunsaturated fatty acids (PUFAs) in phospholipids affect the physical properties of membranes, but it is unclear which biological processes are influenced by their regulation. For example, the functions of membrane arachidonate that are independent of
Tomomi Hashidate-Yoshida, Takeshi Harayama, Daisuke Hishikawa, Ryo Morimoto, Fumie Hamano, Suzumi M Tokuoka, Miki Eto, Miwa Tamura-Nakano, Rieko Yanobu-Takanashi, Yoshiko Mukumoto, Hiroshi Kiyonari, Tadashi Okamura, Yoshihiro Kita, Hideo Shindou, Takao Shimizu   +14 more
doaj   +1 more source

Establishment of LC-MS methods for the analysis of palmitoylated surfactant proteins[S]

Journal of Lipid Research, 2015
The surfactant proteins (SPs), SP-B and SP-C, are important components of pulmonary surfactant involved in the reduction of alveolar surface tension. Quantification of SP-B and SP-C in surfactant drugs is informative for their quality control and the ...
Takeshi Harayama, Hideo Shindou, Yoshihiro Kita, Eiji Otsubo, Kazushige Ikeda, Shoichi Chida, Timothy E. Weaver, Takao Shimizu   +7 more
doaj   +1 more source

The Contribution of Cytosolic Group IVA and Calcium-Independent Group VIA Phospholipase A₂s to Adrenic Acid Mobilization in Murine Macrophages

Biomolecules, 2020
Adrenic acid (AA), the 2-carbon elongation product of arachidonic acid, is present at significant levels in membrane phospholipids of mouse peritoneal macrophages.
Patricia Monge, Alvaro Garrido, Julio M. Rubio, Victoria Magrioti, George Kokotos, María A. Balboa, Jesús Balsinde   +6 more
doaj   +1 more source

Recent Advances in Research on Molecular Mechanisms of Fungal Signaling

Encyclopedia, 2022
Biochemical signaling is one of the key mechanisms to coordinate a living organism in all aspects of its life. It is still enigmatic how exactly cells and organisms deal with environmental signals and irritations precisely because of the limited number ...
Stefan Jacob, Sri Bühring, Katharina Bersching   +2 more
doaj   +1 more source

Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2[S]

Journal of Lipid Research, 2014
Platelet-activating factor (PAF) is a potent pro-inflammatory phospholipid mediator. In response to extracellular stimuli, PAF is rapidly biosynthesized by lyso-PAF acetyltransferase (lyso-PAFAT).
Megumi Tarui, Hideo Shindou, Kazuo Kumagai, Ryo Morimoto, Takeshi Harayama, Tomomi Hashidate, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Takahide Nagase, Takao Shimizu   +10 more
doaj   +1 more source