Results 41 to 50 of about 6,252,566 (347)

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Cell Reports, 2019
Summary: Hematopoietic stem cells (HSCs) maintain lifelong hematopoiesis by remaining quiescent in the bone marrow niche. Recapitulation of a quiescent state in culture has not been achieved, as cells rapidly proliferate and differentiate in vitro. After
Hiroshi Kobayashi, Takayuki Morikawa, Ayumi Okinaga, Fumie Hamano, Tomomi Hashidate-Yoshida, Shintaro Watanuki, Daisuke Hishikawa, Hideo Shindou, Fumio Arai, Yasuaki Kabe, Makoto Suematsu, Takao Shimizu, Keiyo Takubo   +12 more
doaj   +1 more source

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Oxidative Medicine and Cellular Longevity, 2014
Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs).
A. Ayala, Mario F. Muñoz, S. Argüelles
semanticscholar   +1 more source

The role of extended synaptotagmin at membrane contact sites in cancer research

Frontiers in Cell and Developmental Biology, 2023
Membrane contact sites (MCSs) are adjacent locations between the membranes of two different organelles and play important roles in various physiological processes, including cellular calcium and lipid signaling.
Yuetian Pan, Yuetian Pan, Dorothee Strohmer, Shikai Feng, Guibin Zhang, Hongshang Cui, Yongbin Song   +6 more
doaj   +1 more source

Lipid signalling in cardiovascular pathophysiology [PDF]

Cardiovascular Research, 2008
Although the role of lipids in the pathogenesis of cardiovascular disease has been appreciated for several decades, recent studies have advanced our understanding and revealed complex new functions and interactions for lipid molecules that are both beneficial and adverse.
Joel S, Karliner, Joan Heller, Brown
openaire   +2 more sources

Ceramide synthase inhibition by fumonisins: a perfect storm of perturbed sphingolipid metabolism, signaling, and disease[S]

Journal of Lipid Research, 2019
Fumonisins are mycotoxins that cause diseases of plants and, when consumed by animals, can damage liver, kidney, lung, brain, and other organs, alter immune function, and cause developmental defects and cancer.
Ronald T. Riley, Alfred H. Merrill, Jr.
doaj   +1 more source

Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?

Frontiers in Cell and Developmental Biology, 2021
Cholesterol is a lipid molecule that plays an essential role in a number of biological processes, both physiological and pathological. It is an essential structural constituent of cell membranes, and it is fundamental for biosynthesis, integrity, and ...
R. Vona, Elisabetta Iessi, P. Matarrese
semanticscholar   +1 more source

The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes

Journal of Lipid Research, 2019
Phosphoinositides are key regulators of a large number of diverse cellular processes that include membrane trafficking, plasma membrane receptor signaling, cell proliferation, and transcription.
Aby Grabon, Vytas A. Bankaitis, Mark I. McDermott   +2 more
doaj   +1 more source

Salicylic acid modulates levels of phosphoinositide dependent-phospholipase C substrates and products to remodel the Arabidopsis suspension cell transcriptome

Frontiers in Plant Science, 2014
Basal phosphoinositide-dependent phospholipase C (PI-PLC) activity controls gene expression in Arabidopsis suspension cells and seedlings. PI-PLC catalyzes the production of phosphorylated inositol and diacylglycerol (DAG) from phosphoinositides.
Eric eRuelland, Eric eRuelland, Eric eRuelland, Igor ePokotylo, Igor ePokotylo, Catherine eCantrel, Catherine eCantrel, Nabila eDjafi, Anne eRepellin, Alain eZachowski, Alain eZachowski, Alain eZachowski   +11 more
doaj   +1 more source

Pseudomonas aeruginosa Lipoxygenase LoxA Contributes to Lung Infection by Altering the Host Immune Lipid Signaling

Frontiers in Microbiology, 2019
Pseudomonas aeruginosa is an opportunistic bacteria and a major cause of nosocomial pneumonia. P. aeruginosa has many virulence factors contributing to its ability to colonize the host. LoxA is a lipoxygenase enzyme secreted by P.
E. Morello, T. Pérez-Berezo, C. Boisseau, T. Baranek, A. Guillon, D. Bréa, P. Lanotte, X. Carpena, N. Pietrancosta, V. Hervé, R. Ramphal, N. Cenac, M. Si-Tahar   +12 more
semanticscholar   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source