Results 41 to 50 of about 6,052,075 (348)
Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo
Cell Reports, 2019 Summary: Hematopoietic stem cells (HSCs) maintain lifelong hematopoiesis by remaining quiescent in the bone marrow niche. Recapitulation of a quiescent state in culture has not been achieved, as cells rapidly proliferate and differentiate in vitro. After
Hiroshi Kobayashi +12 more
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Lipid phosphate phosphatases and signaling
Journal of Lipid Research, 2009 Lipid phosphate phosphatases (LPPs) regulate cell signaling by modifying the concentrations of lipid phosphates versus their dephosphorylated products. The ecto-activity regulates the availability of extracellular lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P) and thereby signaling by their respective receptors.
Carlos Pilquil, David N. Brindley
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Lipid signaling on the mitochondrial surface [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009 Regulated production and elimination of the signaling lipids phosphatidic acid (PA), diacylglycerol (DAG), and phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) creates a complex and interconnected signaling network that modulates a wide variety of eukaryotic cell biological events.
Huiyan Huang, Michael A. Frohman
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Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?
Frontiers in Cell and Developmental Biology, 2021 Cholesterol is a lipid molecule that plays an essential role in a number of biological processes, both physiological and pathological. It is an essential structural constituent of cell membranes, and it is fundamental for biosynthesis, integrity, and ...
R. Vona, Elisabetta Iessi, P. Matarrese
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Journal of Lipid Research, 2019 Fumonisins are mycotoxins that cause diseases of plants and, when consumed by animals, can damage liver, kidney, lung, brain, and other organs, alter immune function, and cause developmental defects and cancer.
Ronald T. Riley, Alfred H. Merrill, Jr.
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Lipid signals and insulin resistance
Clinical Lipidology, 2013 The metabolic syndrome, a cluster of metabolic derangements that include obesity, glucose intolerance, dyslipidemia and hypertension, is a major risk factor for cardiovascular disease. Insulin resistance has been proposed to be the common feature that links obesity to the metabolic syndrome, but the mechanism remains obscure.
Rosalind A. Coleman +2 more
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Journal of Lipid Research, 2019 Phosphoinositides are key regulators of a large number of diverse cellular processes that include membrane trafficking, plasma membrane receptor signaling, cell proliferation, and transcription.
Aby Grabon +2 more
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Biomolecules, 2020 Adrenic acid (AA), the 2-carbon elongation product of arachidonic acid, is present at significant levels in membrane phospholipids of mouse peritoneal macrophages.
Patricia Monge +6 more
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Lipid signalling in cardiovascular pathophysiology [PDF]
Cardiovascular Research, 2008 Although the role of lipids in the pathogenesis of cardiovascular disease has been appreciated for several decades, recent studies have advanced our understanding and revealed complex new functions and interactions for lipid molecules that are both beneficial and adverse.
Joan Heller Brown +2 more
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Crosstalk between phospholipase D and sphingosine kinase in plant stress signaling
Frontiers in Plant Science, 2012 The activation of phospholipase D (PLD) produces phosphatidic acid (PA), whereas sphingosine kinase (SPHK) phosphorylates long-chain bases (LCBs) to generate LCB-1-phosphates (LCBPs) such as phytosphingosine-1-phosphate (phyto-S1P). PA and phyto-S1P have
Xuemin eWang
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