Results 51 to 60 of about 6,052,075 (348)

A live-cell ergosterol reporter for visualization of the effects of fluconazole on the human fungal pathogen Candida albicans

open access: yesmBio, 2023
Ergosterol, an essential plasma membrane amphipathic lipid, is a major component of the fungal plasma membrane. Most fungal pathogens are susceptible to azole drugs that target ergosterol biosynthesis, and resistance/tolerance to azoles is increasingly ...
Antonio Serrano   +3 more
doaj   +1 more source

A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins

open access: yeseLife, 2020
Yeast Sfh5 is an unusual member of the Sec14-like phosphatidylinositol transfer protein (PITP) family. Whereas PITPs are defined by their abilities to transfer phosphatidylinositol between membranes in vitro, and to stimulate phosphoinositide signaling ...
Danish Khan   +12 more
doaj   +1 more source

Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis

open access: yesThe Journal of General Physiology, 2018
Hilgemann et al. explain how lipid signaling to membrane proteins involves a hierarchy of mechanisms from lipid binding to membrane domain coalescence.
D. Hilgemann   +6 more
semanticscholar   +1 more source

The Escherichia coli Phospholipase PldA Regulates Outer Membrane Homeostasis via Lipid Signaling

open access: yesmBio, 2018
The outer membrane (OM) bilayer of Gram-negative bacteria is biologically unique in its asymmetrical organization of lipids, with an inner leaflet composed of glycerophospholipids (PLs) and a surface-exposed outer leaflet composed of lipopolysaccharide ...
Kerrie L. May, T. Silhavy
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Lipid Signaling in Pathogenic Fungi [PDF]

open access: yesAnnual Review of Microbiology, 2009
Lipid signaling in pathogenic fungi has been studied to determine the role of these pathways in fungal biology and human infections. Owing to their unique nature, they may represent targets for future antifungal treatments. Farnesol signaling was characterized as a quorum-sensing molecule, with exposure inhibiting filamentation.
Maurizio Del Poeta, Ryan Rhome
openaire   +5 more sources

Salicylic acid modulates levels of phosphoinositide dependent-phospholipase C substrates and products to remodel the Arabidopsis suspension cell transcriptome

open access: yesFrontiers in Plant Science, 2014
Basal phosphoinositide-dependent phospholipase C (PI-PLC) activity controls gene expression in Arabidopsis suspension cells and seedlings. PI-PLC catalyzes the production of phosphorylated inositol and diacylglycerol (DAG) from phosphoinositides.
Eric eRuelland   +11 more
doaj   +1 more source

The role of extended synaptotagmin at membrane contact sites in cancer research

open access: yesFrontiers in Cell and Developmental Biology, 2023
Membrane contact sites (MCSs) are adjacent locations between the membranes of two different organelles and play important roles in various physiological processes, including cellular calcium and lipid signaling.
Yuetian Pan   +6 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation

open access: yesFrontiers in Cellular Neuroscience, 2014
A family of endogenous lipids, structurally analogous to the endogenous cannabinoid, N-arachidonoyl ethanolamine (Anandamide), and called N-acyl amides have emerged as a family of biologically active compounds at TRP receptors.
Siham eRaboune   +10 more
doaj   +1 more source

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