Results 81 to 90 of about 6,052,075 (348)

Regulation of Membrane Turnover by Phosphatidic Acid: Cellular Functions and Disease Implications

Frontiers in Cell and Developmental Biology, 2019
Phosphatidic acid (PA) is a simple glycerophospholipid with a well-established role as an intermediate in phospholipid biosynthesis. In addition to its role in lipid biosynthesis, PA has been proposed to act as a signaling molecule that modulates several
Rajan Thakur, Amruta Naik, Aniruddha Panda, Padinjat Raghu   +3 more
doaj   +1 more source

Molecular cause and functional impact of altered synaptic lipid signaling due to a prg‐1 gene SNP

EMBO Molecular Medicine, 2015
Loss of plasticity‐related gene 1 (PRG‐1), which regulates synaptic phospholipid signaling, leads to hyperexcitability via increased glutamate release altering excitation/inhibition (E/I) balance in cortical networks.
J. Vogt, Jenq-Wei Yang, A. Mobascher, Jin Cheng, Yunbo Li, Xingfeng Liu, Jan Baumgart, Carine Thalman, S. Kirischuk, P. Unichenko, Guilherme Horta, K. Radyushkin, A. Stroh, S. Richers, N. Sahragard, Ute Distler, S. Tenzer, Lianyong Qiao, K. Lieb, O. Tüscher, H. Binder, N. Ferreirós, I. Tegeder, A. Morris, Sergiu Gropa, P. Nürnberg, M. Toliat, G. Winterer, Heiko J. Luhmann, Jisen Huai, R. Nitsch   +30 more
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Extracellular Spermine Triggers a Rapid Intracellular Phosphatidic Acid Response in Arabidopsis, Involving PLDδ Activation and Stimulating Ion Flux

Frontiers in Plant Science, 2019
Polyamines, such as putrescine (Put), spermidine (Spd), and spermine (Spm), are low-molecular-weight polycationic molecules found in all living organisms.
Xavier Zarza, Xavier Zarza, Lana Shabala, Miki Fujita, Sergey Shabala, Michel A. Haring, Antonio F. Tiburcio, Teun Munnik, Teun Munnik   +8 more
doaj   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Biochemical and molecular-genetic characterization of SFD1’s involvement in lipid metabolism and defense signaling

Frontiers in Plant Science, 2012
The Arabidopsis thaliana SFD1 (SUPPRESSOR OF FATTY ACID DESATURASE DEFICIENCY1) gene (also known as GLY1) is required for accumulation of 34:6 (i.e., 18:3-16:3) monogalactosyldiacylglycerol (MGDG) and for the activation of systemic acquired resistance ...
Katarzyna eLorenc-Kukula, Ratnesh eChaturvedi, Mary eRoth, Ruth eWelti, Jyoti eShah   +4 more
doaj   +1 more source

SEC14 Phospholipid Transfer Protein Is Involved in Lipid Signaling-Mediated Plant Immune Responses in Nicotiana benthamiana

PLoS ONE, 2014
We previously identified a gene related to the SEC14-gene phospholipid transfer protein superfamily that is induced in Nicotiana benthamiana (NbSEC14) in response to infection with Ralstonia solanacearum. We here report that NbSEC14 plays a role in plant
A. Kiba, I. Galis, Yuko Hojo, K. Ohnishi, H. Yoshioka, Y. Hikichi   +5 more
semanticscholar   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Metabolism and phospholipid assembly of polyunsaturated fatty acids in human bone marrow mesenchymal stromal cells1

Journal of Lipid Research, 2017
High arachidonic acid (20:4n-6) and low n-3 PUFA levels impair the capacity of cultured human bone marrow mesenchymal stromal cells (hBMSCs) to modulate immune functions.
Feven Tigistu-Sahle, Milla Lampinen, Lotta Kilpinen, Minna Holopainen, Petri Lehenkari, Saara Laitinen, Reijo Käkelä   +6 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source