Results 81 to 90 of about 6,252,566 (347)

Metabolism and phospholipid assembly of polyunsaturated fatty acids in human bone marrow mesenchymal stromal cells1

Journal of Lipid Research, 2017
High arachidonic acid (20:4n-6) and low n-3 PUFA levels impair the capacity of cultured human bone marrow mesenchymal stromal cells (hBMSCs) to modulate immune functions.
Feven Tigistu-Sahle, Milla Lampinen, Lotta Kilpinen, Minna Holopainen, Petri Lehenkari, Saara Laitinen, Reijo Käkelä   +6 more
doaj   +1 more source

Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition

Proceedings of the National Academy of Sciences of the United States of America, 2015
Significance Lipid transmitters, such as endocannabinoid and eicosanoids, play important roles in the nervous system and regulate behaviors that include pain, emotionality, and addiction.
Daisuke Ogasawara, H. Deng, Andreu Viader, M. Baggelaar, Arjen C. Breman, H. den Dulk, A. M. V. D. van den Nieuwendijk, Marjolein Soethoudt, T. van der Wel, Juan Zhou, H. Overkleeft, M. Sánchez-Alavez, Simone Mori, William Nguyen, B. Conti, Xiaojie Liu, Yao-Fong Chen, Qing-song Liu, B. Cravatt, Mario van der Stelt   +19 more
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Structural elements that govern Sec14-like PITP sensitivities to potent small molecule inhibitors[S]

Journal of Lipid Research, 2016
Sec14-like phosphatidylinositol transfer proteins (PITPs) play important biological functions in integrating multiple aspects of intracellular lipid metabolism with phosphatidylinositol-4-phosphate signaling.
Danish Khan, Kaitlyn R. McGrath, Oleksandra Dorosheva, Vytas A. Bankaitis, Ashutosh Tripathi   +4 more
doaj   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Lack of GPR180 ameliorates hepatic lipid depot via downregulation of mTORC1 signaling [PDF]

, 2023
Ken Yoshida, Kazuha Yokota, Kazuhisa Watanabe, Hidetoshi Tsuda, Ayumi Matsumoto, Hiroaki Mizukami, Sadahiko Iwamoto   +6 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Phloem proteomics reveals new lipid-binding proteins with a putative role in lipid-mediated signaling

Frontiers in Plant Science, 2016
Global climate changes inversely affect our ability to grow the food required for an increasing world population. To combat future crop loss due to abiotic stress, we need to understand the signals responsible for changes in plant development and the ...
Allison Marie Barbaglia, Banita eTamot, Veronica eGreve, Susanne eHoffmann-Benning   +3 more
doaj   +1 more source

Molecular cause and functional impact of altered synaptic lipid signaling due to a prg‐1 gene SNP

EMBO Molecular Medicine, 2015
Loss of plasticity‐related gene 1 (PRG‐1), which regulates synaptic phospholipid signaling, leads to hyperexcitability via increased glutamate release altering excitation/inhibition (E/I) balance in cortical networks.
J. Vogt, Jenq-Wei Yang, A. Mobascher, Jin Cheng, Yunbo Li, Xingfeng Liu, Jan Baumgart, Carine Thalman, S. Kirischuk, P. Unichenko, Guilherme Horta, K. Radyushkin, A. Stroh, S. Richers, N. Sahragard, Ute Distler, S. Tenzer, Lianyong Qiao, K. Lieb, O. Tüscher, H. Binder, N. Ferreirós, I. Tegeder, A. Morris, Sergiu Gropa, P. Nürnberg, M. Toliat, G. Winterer, Heiko J. Luhmann, Jisen Huai, R. Nitsch   +30 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source