Results 1 to 10 of about 23,453 (286)

The Emerging Roles of Protein Lipidation in Fertility and Reproductive Disorders: Mechanisms and Therapeutic Implications [PDF]

Biomolecules
Protein lipidation, a pivotal post-translational modification, dynamically regulates cellular signaling, membrane trafficking, and protein stability, with emerging roles in reproductive physiology.
Heran Cao, Xiaohua Liu, Shenghui Zhu, Hua Nie, Shujuan Liu, Jun Fan, Weibing Qin   +6 more
doaj   +2 more sources

Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics [PDF]

Molecular Cancer
Protein lipidation is a pivotal post-translational modification that increases protein hydrophobicity and influences their function, localization, and interaction network.
Mengke Xu, Bo Xu
doaj   +2 more sources

Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins [PDF]

Nature Communications
Lipid-anchored proteins are integral components of cell surfaces. In bacteria, lipidation of proteins with a conserved lipobox motif ([L/V/I]−3 [A/S/T/V/I]−2 [G/A/S]−1 [C]+1) is catalyzed by prolipoprotein diacylglyceryl transferase (Lgt).
Yirui Hong, Kira S. Makarova, Andy A. Garcia, Rachel Xu, Friedhelm Pfeiffer, Paula V. Welander, Mechthild Pohlschroder   +6 more
doaj   +2 more sources

Antimicrobial Peptides: Current Status, Mechanisms of Action, and Strategies to Overcome Therapeutic Limitations [PDF]

Microorganisms
Antimicrobial peptides (AMPs), evolutionarily conserved components of the immune system, have attracted considerable attention as promising therapeutic candidates.
Seong Hwan Kim, Yu-Hong Min, Min Chul Park   +2 more
doaj   +2 more sources

Lipoprotein Signal Peptide as Adjuvants: Leveraging Lipobox-Driven TLR2 Activation in Modern Vaccine Design [PDF]

Vaccines
Toll-like receptor 2 (TLR2) signaling is a pivotal component of immune system activation, and it is closely linked to the lipidation of bacterial proteins.
Muhammad Umar, Haroon Afzal, Asad Murtaza, Li-Ting Cheng   +3 more
doaj   +2 more sources

E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I [PDF]

, 2013
p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified.
C Stumptner, E Kuusisto, M Yamaguchi, Michael T. Stang, ML Seibenhener, N Fujita, N Fujita, N Mizushima, N Mizushima, N Mizushima, N Mizushima, N Mizushima, NN Noda, S Hardy, S Pankiv, T Nakano, W Gao, Wei Wang, Wei-Guo Zhu, Wentao Gao, Y Ichimura, Y Ichimura, Y Ichimura, Y Kabeya, Zhixia Chen   +24 more
core   +10 more sources

APOE and Alzheimer’s Disease: From Lipid Transport to Physiopathology and Therapeutics

Frontiers in Neuroscience, 2021
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by extracellular amyloid β (Aβ) and intraneuronal tau protein aggregations.
Mohammed Amir Husain, Mohammed Amir Husain, Benoit Laurent, Benoit Laurent, Mélanie Plourde, Mélanie Plourde   +5 more
doaj   +1 more source

An in Silico Approach to Reveal the Nanodisc Formulation of Doxorubicin

Frontiers in Bioengineering and Biotechnology, 2022
Molecular dynamic behaviors of nanodisc (ND) formulations of free doxorubicin (DOX) and DOX conjugated lipid prodrug molecules were investigated by molecular dynamics (MD) simulations.
Daiyun Xu, Xu Chen, Zhidong Chen, Yonghui Lv, Yongxiao Li, Shengbin Li, Wanting Xu, Yuan Mo, Xinpei Wang, Zirui Chen, Tingyi Chen, Tianqi Wang, Zhe Wang, Meiying Wu, Junqing Wang   +14 more
doaj   +1 more source

Cell biology of protein–lipid conjugation

Cell Structure and Function, 2023
Protein–lipid conjugation is a widespread modification involved in many biological processes. Various lipids, including fatty acids, isoprenoids, sterols, glycosylphosphatidylinositol, sphingolipids, and phospholipids, are covalently linked with proteins.
Jun-ichi Sakamaki, Noboru Mizushima
doaj   +1 more source

Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity [PDF]

, 2014
During macroautophagy, conjugation of ATG12 to ATG5 is essential for LC3 lipidation and autophagosome formation. Additionally, ATG12 has ATG5-independent functions in diverse processes including mitochondrial fusion and mitochondrial-dependent apoptosis.
Debnath, Jayanta, Giampazolias, Evangelos, Green, Douglas R., Haller, Martina, Hock, Andreas K., Oberst, Andrew, Ryan, Kevin M., Tait, Stephen W. G., Vousden, Karen H.   +8 more
core   +9 more sources