Results 91 to 100 of about 75,579 (341)

Lipogenesis in cancer progression (Review)

International Journal of Oncology, 2014
In normal tissues, energy-providing lipids come principally from circulating lipids. However, in growing tumors, energy supply is mainly provided by lipids coming from de novo synthesis. It is not surprising to see elevated expression of several lipogenic genes in tumors from different origins.
Lamia Bouraoui, Catherine Mounier, Eric Rassart   +2 more
openaire   +3 more sources

Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A

Nature Communications, 2020
Hepatic lipogenesis is normally tightly regulated but is aberrantly elevated in obesity. Fibroblast Growth Factor-15/19 (mouse FGF15, human FGF19) are bile acid-induced late fed-state gut hormones that decrease hepatic lipid levels by unclear mechanisms.
Young-Chae Kim, Sunmi Seok, Yang Zhang, Jian Ma, Bo Kong, G. Guo, B. Kemper, J. Kemper   +7 more
semanticscholar   +1 more source

Inhibition of Tumor Lipogenesis and Growth by Peptide‐Based Targeting of SREBP Activation

Advanced Science, EarlyView.
A peptide that replicates the amino acid sequence in Insig1/2 loop 1 inhibits the IGF1‐induced interaction between PCK1 and Insig1/2, PCK1‐mediated phosphorylation of Insig1/2, and SREBP activity‐dependent lipid synthesis. Administration of the LNP‐Insig1/2 loop 1 peptide effectively attenuates tumor growth and sensitizes tumors to the antitumor effect
Shudi Luo, Huang Yang, Xiaoming Jiang, Zheng Wang, Xuxiao He, Ying Meng, Shan Li, Min Li, Daqian Xu, Zhengwei Mao, Zhimin Lu   +10 more
wiley   +1 more source

The Effect of Vasopressin on Lipogenesis in Vitro

Journal of Biological Chemistry, 1966
Abstract 1. Significant inhibition of CO2 production and lipogenesis from acetate-1-14C and pyruvate-2-14C occurred in the presence of 1.6 µm vasopressin, in rat liver slices and in homogenates. 2. This effect cannot be reproduced by cyclic adenosine monophosphate, nor can it be accounted for by lipolysis or by glycogenolysis-induced dilution of a ...
John C. Beck, Isadore Horowitz, David Rubinstein   +2 more
openaire   +3 more sources

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice[S]

Journal of Lipid Research, 2018
Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which transcriptionally activates genes involved in FA synthesis, whereas glucose activates carbohydrate-responsive element-binding protein (ChREBP), which activates ...
Albert G Linden, Shili Li, H. Y. Choi, Fei Fang, M. Fukasawa, K. Uyeda, R. Hammer, J. Horton, Luke J. Engelking, G. Liang   +9 more
semanticscholar   +1 more source

Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis

Nature Communications, 2020
Fatty acid and triglyceride synthesis increases greatly in response to feeding and insulin. This lipogenic induction involves coordinate transcriptional activation of various enzymes in lipogenic pathway, including fatty acid synthase and glycerol-3 ...
J. Viscarra, Yuhui Wang, Hai P. Nguyen, Y. Choi, H. Sul   +4 more
semanticscholar   +1 more source

Synergistic Promotion of Triple‐Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella‐Derived Glutamate and Platelet Activation

Advanced Science, EarlyView.
Polystyrene nanoplastics (PS‐NPs) administered via oral exposure accelerate triple‐negative breast cancer (TNBC) progression by synergistically modulating gut microbiota‐derived glutamate production and platelet activation. This study uncovers a pivotal crosstalk between microbial metabolites and platelet‐tumor interactions, offering mechanistic ...
Leilei Zhu, Peihao Xu, Mingyuan Zhou, Kewei Li, Shasha Tian, Xuemei Fan, Junling Liu, Baodong Ye, Zhishan Ding, Yingzhi Shen   +9 more
wiley   +1 more source

The role of bacterial metabolites derived from aromatic amino acids in non-alcoholic fatty liver disease

Alʹmanah Kliničeskoj Mediciny, 2020
The review deals with the role of aromatic amino acids and their microbial metabolites in the development and progression of non-alcoholic fatty liver disease (NAFLD).
E. S. Shcherbakova, T. S. Sall, S. I. Sitkin, T. Ya. Vakhitov, E. V. Demyanova   +4 more
doaj   +1 more source

In Vivo Lipogenesis in the Domestic Chicken

Experimental Biology and Medicine, 1968
SummaryThe ability of chicks to utilize glucose-U-14C and acetate-1-14C as substrates for lipid synthesis has been studied. Chicks readily incorporated glucose and acetate carbon into fatty acids and nonsaponifiable lipids of liver and adipose tissue. Glucose-U-14C was also utilized for glyceride-glycerol formation.
Gilbert A. Leveille, Chakbabarty K, O'Hea Ek   +2 more
openaire   +3 more sources

Polarization‐Sensitive Holotomography for Multidimensional Label‐Free Imaging and Characterization of Lipid Droplets in Cancer Cells

Advanced Science, EarlyView.
Polarization‐sensitive holotomography (PS‐HT) enables label‐free 3D imaging and quantitative analysis of lipid droplets by exploiting their intrinsic birefringence. Applied to prostate cell models, PS‐HT reveals glucose‐induced lipid accumulation in cancer cells and achieves near‐perfect classification of healthy and cancerous states.
Hossein Khadem, Maria Mangini, Maria Antonietta Ferrara, Anna Chiara De Luca, Giuseppe Coppola   +4 more
wiley   +1 more source