Results 11 to 20 of about 75,579 (341)
Transcriptional regulation of hepatic lipogenesis [PDF]
Nature Reviews Molecular Cell Biology, 2015 Fatty acid and fat synthesis in the liver is a highly regulated metabolic pathway that is important for very low-density lipoprotein (VLDL) production and thus energy distribution to other tissues. Having common features at their promoter regions, lipogenic genes are coordinately regulated at the transcriptional level.
Wang, Yuhui +3 more
openaire +6 more sources
Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease [PDF]
Journal of Clinical Investigation, 2019 BACKGROUND An increase in intrahepatic triglyceride (IHTG) is the hallmark feature of nonalcoholic fatty liver disease (NAFLD) and is decreased by weight loss. Hepatic de novo lipogenesis (DNL) contributes to steatosis in people with NAFLD.
Gordon I. Smith +13 more
openalex +2 more sources
Lipogenesis inhibitors: therapeutic opportunities and challenges
Nature reviews. Drug discovery, 2022 Fatty acids are essential for survival, acting as bioenergetic substrates, structural components and signalling molecules. Given their vital role, cells have evolved mechanisms to generate fatty acids from alternative carbon sources, through a process ...
Battsetseg Batchuluun +2 more
semanticscholar +1 more source
FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth
Signal Transduction and Targeted Therapy, 2023 Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor. FBXW7 is a highly mutated gene in CRC, but its biological functions in cancer are not fully characterized.
Wenxia Wei +18 more
semanticscholar +1 more source
Role of LXRs in control of lipogenesis [PDF]
Genes & Development, 2000 The discovery of oxysterols as the endogenous liver X receptor (LXR) ligands and subsequent gene targeting studies in mice provided strong evidence that LXR plays a central role in cholesterol metabolism.
Joshua R. Schultz +11 more
openalex +2 more sources
Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer
Frontiers in Oncology, 2022 Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from the same gene for regulating the genes of lipogenesis, including acetyl-CoA ...
Qiushi Zhao, Xingyu Lin, Guan Wang
semanticscholar +1 more source
Nature Metabolism, 2022 Tumorigenesis is associated with elevated glucose and glutamine consumption, but how cancer cells can sense their levels to activate lipid synthesis is unknown. Here, we reveal that ammonia, released from glutamine, promotes lipogenesis via activation of
Chunming Cheng +12 more
semanticscholar +1 more source
FASN-dependent de novo lipogenesis is required for brain development
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Regulation of cellular metabolism in proliferating progenitor cells and their neuronal progeny is critical for brain development and function.
Daniel Gonzalez-Bohorquez +6 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance This work demonstrates that oncogenic activation of the PI3K-AKT-mTOR signaling pathway suppresses ferroptosis via the sterol regulatory element-binding protein-mediated lipogenesis, and that inhibition of this pathway potentiates the cancer
Junmei Yi +4 more
semanticscholar +1 more source
Serine catabolism generates liver NADPH and supports hepatic lipogenesis
Nature Metabolism, 2021 Carbohydrate can be converted into fat by de novo lipogenesis, a process upregulated in fatty liver disease. Chemically, de novo lipogenesis involves polymerization and reduction of acetyl-CoA, using NADPH as the electron donor.
Zhaoyue Zhang +8 more
semanticscholar +1 more source