Results 31 to 40 of about 77,919 (340)

Chia (Salvia hispanica L.) Flour and Oil Ameliorate Metabolic Disorders in the Liver of Rats Fed a High-Fat and High Fructose Diet

Foods, 2022
We hypothesized that the consumption of chia (Salvia hispanica L.) flour (CF) and chia oil (CO) improves metabolic disorders in the liver of Wistar rats (Rattus norvegicus domestica) fed a high-fat and high-fructose (HFHF) diet.
Luiza de Paula Dias Moreira, Bárbara Nery Enes, Vinícius Parzanini Brilhante de São José, Renata Celi Lopes Toledo, Luiz Carlos Maia Ladeira, Rodrigo Rezende Cardoso, Vinícius da Silva Duarte, Helen Hermana Miranda Hermsdorff, Frederico Augusto Ribeiro de Barros, Hércia Stampini Duarte Martino   +9 more
doaj   +1 more source

Novel Insights into the Differences in Nutrition Value, Gene Regulation and Network Organization between Muscles from Pasture-Fed and Barn-Fed Goats

Foods, 2022
The physiological and biochemical characters of muscles derived from pasture-fed or barn-fed black goats were detected, and RNA-seq was performed to reveal the underlying molecular mechanisms to identify how the pasture feeding affected the nutrition and
Yufeng Yang, Yan Wang, Huiquan Shan, Yalin Zheng, Zeyi Xuan, Jinling Hu, Mingsong Wei, Zhiqiang Wang, Qingyou Liu, Zhipeng Li   +9 more
doaj   +1 more source

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease.

Journal of Clinical Investigation, 2019
BACKGROUND An increase in intrahepatic triglyceride (IHTG) is the hallmark feature of nonalcoholic fatty liver disease (NAFLD) and is decreased by weight loss. Hepatic de novo lipogenesis (DNL) contributes to steatosis in people with NAFLD.
Gordon I. Smith, M. Shankaran, M. Yoshino, G. Schweitzer, M. Chondronikola, Joseph W. Beals, A. Okunade, B. Patterson, Edna Nyangau, T. Field, C. Sirlin, Saswata Talukdar, M. Hellerstein, S. Klein   +13 more
semanticscholar   +1 more source

Alcohol effects on hepatic lipid metabolism

Journal of Lipid Research, 2020
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis.
Sookyoung Jeon, Rotonya Carr
doaj   +1 more source

Anti-Obesity Effect of Dyglomera^® Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced Obesity

Molecules, 2022
Dyglomera® is an aqueous ethanol extract of the fruit pods of Dichrostachys glomerata, a Cameroonian spice. Several studies have shown its anti-diabetic and anti-obesity effects. However, the underlying mechanisms for such effects remain unclear.
Hae-Lim Kim, Sung-Kwon Lee, Da-Eun Min, Bong-Keun Choi, Dong-Ryung Lee   +4 more
doaj   +1 more source

Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis.

Nature Metabolism, 2020
Non-alcoholic fatty liver disease and steatohepatitis are highly associated with obesity and type 2 diabetes mellitus. Cotadutide, a glucagon-like protein-1 receptor (GLP-1R) and glucagon receptor (GCGR) agonist, was shown to reduce blood glycaemia, body
Michelle L. Boland, R. Laker, Karly M. Mather, A. Nawrocki, Stephanie N. Oldham, B. Boland, H. Lewis, James Conway, Jacqueline Naylor, S. Guionaud, M. Feigh, S. Veidal, L. Lantier, O. McGuinness, J. Grimsby, C. Rondinone, L. Jermutus, M. Larsen, James L. Trevaskis, C. Rhodes   +19 more
semanticscholar   +1 more source

Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis

Nature Communications, 2018
Insulin promotes lipogenesis but, on the other hand, insulin resistance is associated with increased lipogenesis in the liver. Here the authors show that Snail1 is upregulated by insulin and inhibits lipogenesis by repressing Fasn expression but insulin ...
Yan Liu, Lin Jiang, Chengxin Sun, Nicole Ireland, Yatrik M. Shah, Yong Liu, Liangyou Rui   +6 more
doaj   +1 more source

NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions

Cell Reports, 2021
Summary: Citrate lies at a critical node of metabolism, linking tricarboxylic acid metabolism and lipogenesis via acetyl-coenzyme A. Recent studies have observed that deficiency of the sodium-dependent citrate transporter (NaCT), encoded by SLC13A5 ...
Avi Kumar, Thekla Cordes, Anna E. Thalacker-Mercer, Ana M. Pajor, Anne N. Murphy, Christian M. Metallo   +5 more
doaj   +1 more source

The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis

Journal of Cell Biology, 2021
Labbé et al. demonstrate that the modified outer membrane carrier protein, MTCH2, is required for starvation-dependent mitochondrial hyperfusion in human cells and functions to stimulate mitochondrial fusion in a manner dependent on lysophosphatidic acid,
K. Labbé, S. Mookerjee, Maxence Le Vasseur, Eddy Gibbs, C. Lerner, J. Nunnari   +5 more
semanticscholar   +1 more source

Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice

eLife, 2017
Obesity poses a significant risk of developing type II diabetes and other diseases. Hedgehog (Hh) signaling has been shown to inhibit adipose tissue development, but its effect on diet-induced obesity during postnatal life is not known.
Yu Shi, Fanxin Long
doaj   +1 more source