Results 41 to 50 of about 77,919 (340)
Expanding Roles of De Novo Lipogenesis in Breast Cancer
International Journal of Environmental Research and Public Health, 2021 In recent years, lipid metabolism has gained greater attention in several diseases including cancer. Dysregulation of fatty acid metabolism is a key component in breast cancer malignant transformation.
P. Simeone +8 more
semanticscholar +1 more source
Diacylglycerol Kinase Delta Promotes Lipogenesis [PDF]
Biochemistry, 2013 We have studied the relationship between diacylglycerol kinase delta (DGKδ) and lipogenesis. There is a marked increase in the expression of DGKδ during the differentiation of 3T3-L1 cells to adipocytes, as well as in the synthesis of neutral and polar lipids.
Yulia V, Shulga +12 more
openaire +2 more sources
Animal, 2017 Feeding a high concentrate (HC) diet is a widely used strategy for supporting high milk yields, yet it may cause certain metabolic disorders. This study aimed to investigate the changes in milk production and hepatic metabolism in goats fed different ...
H.B. Dong +7 more
doaj +1 more source
Lipogenesis in Rat Hepatocytes
Journal of Biological Chemistry, 1974 Abstract Hepatocytes, prepared by collagenase treatment of livers of ad libitum- and meal-fed rats, were incubated with glucose, fructose, lactate, and a number of other substrates, labeled uniformly with 14C and in the presence of 3HOH. The uptake of lactate and the incorporation of 14C into CO2 and glucose equals or exceeds rates reported in perfused
D G, Clark, R, Rognstad, J, Katz
openaire +2 more sources
Frontiers in Physiology, 2019 MicroRNAs (miRNAs) are known regulators of lipid homeostasis. We recently demonstrated that miR-29 controls the levels of circulating cholesterol and triglycerides, but the mechanisms remained unknown.
Yu-Han Hung +10 more
doaj +1 more source
Molecular Medicine, 2019 Non-alcoholic fatty liver disease (NAFLD) is a common hepatic disease with an increasing prevalence but an unclear aetiology. This study aimed to investigate the functional implications of microRNA-122 (miR-122) in the pathogenesis of NAFLD and the ...
J. Long +3 more
semanticscholar +1 more source
Frontiers in Bioengineering and Biotechnology, 2023 Introduction: Systematic gene knockout studies may offer us novel insights on cell metabolism and physiology. Specifically, the lipid accumulation mechanism at the molecular or cellular level is yet to be determined in the oleaginous yeast Y.
Jiang Zhu +9 more
doaj +1 more source
PEG3 controls lipogenesis through ACLY
PLOS ONE, 2021 Peg3 (Paternally expressed gene 3) is an imprinted gene encoding a DNA-binding protein that is a well-known transcriptional repressor. Previous studies have shown that the mutant phenotypes of Peg3 are associated with the over-expression of genes involved in lipid metabolism. In the current study, we investigated four potential downstream genes of Peg3,
Subash Ghimire, Joomyeong Kim
openaire +4 more sources
Engineering
mBio, 2018 Throughout history, the yeast Saccharomyces cerevisiae has played a central role in human society due to its use in food production and more recently as a major industrial and model microorganism, because of the many genetic and genomic tools available ...
Paul Cernak +13 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 MAF1 is a nutrient-sensitive, TORC1-regulated repressor of RNA polymerase III (Pol III). MAF1 downregulation leads to increased lipogenesis in Drosophila melanogaster, Caenorhabditis elegans, and mice.
Gilles Willemin +8 more
doaj +1 more source