Results 41 to 50 of about 75,579 (341)

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy [PDF]

Nature Communications, 2018
Whereas significant anti-tumor responses are observed in most BRAFV600E-mutant melanoma patients exposed to MAPK-targeting agents, resistance almost invariably develops.
Ali Talebi, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, David Nittner, Rita Derua, Frank Vanderhoydonc, João Duarte, Francesca M. Bosisio, Kathleen Van den Eynde, Kris Nys, Mónica Vara‐Pérez, Patrizia Agostinis, Etienne Waelkens, Joost van den Oord, Sarah‐Maria Fendt, Jean‐Christophe Marine, Johannes V. Swinnen   +17 more
openalex   +2 more sources

Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice

eLife, 2017
Obesity poses a significant risk of developing type II diabetes and other diseases. Hedgehog (Hh) signaling has been shown to inhibit adipose tissue development, but its effect on diet-induced obesity during postnatal life is not known.
Yu Shi, Fanxin Long
doaj   +1 more source

Changes in milk performance and hepatic metabolism in mid-lactating dairy goats after being fed a high concentrate diet for 10 weeks

Animal, 2017
Feeding a high concentrate (HC) diet is a widely used strategy for supporting high milk yields, yet it may cause certain metabolic disorders. This study aimed to investigate the changes in milk production and hepatic metabolism in goats fed different ...
H.B. Dong, L.L. Sun, R.H. Cong, S.Y. Tao, Y.Q. DuanMu, J. Tian, Y.D. Ni, R.Q. Zhao   +7 more
doaj   +1 more source

Hormonal Regulation of Lipogenesis

, 2013
Obesity has reached epidemic proportions with severe heath consequences including type 2 diabetes, nonalcoholic fatty liver disease, and premature cardiovascular mortality. Understanding the biological processes that govern fat deposition in a tissue-specific manner is therefore crucial if we are to try to design novel and efficacious treatments that ...
Gathercole, L, Morgan, SA, Tomlinson, J
openaire   +3 more sources

Lipogenesis in Rat Hepatocytes

Journal of Biological Chemistry, 1974
Abstract Hepatocytes, prepared by collagenase treatment of livers of ad libitum- and meal-fed rats, were incubated with glucose, fructose, lactate, and a number of other substrates, labeled uniformly with 14C and in the presence of 3HOH. The uptake of lactate and the incorporation of 14C into CO2 and glucose equals or exceeds rates reported in perfused
Joseph Katz, Dallas G. Clark, Robert Rognstad   +2 more
openaire   +3 more sources

MiR-29 Regulates de novo Lipogenesis in the Liver and Circulating Triglyceride Levels in a Sirt1-Dependent Manner

Frontiers in Physiology, 2019
MicroRNAs (miRNAs) are known regulators of lipid homeostasis. We recently demonstrated that miR-29 controls the levels of circulating cholesterol and triglycerides, but the mechanisms remained unknown.
Yu-Han Hung, Matt Kanke, Catherine Lisa Kurtz, Rebecca L. Cubitt, Rodica P. Bunaciu, Liye Zhou, Phillip J. White, Kasey C. Vickers, Mohammed Mahmood Hussain, Xiaoling Li, Praveen Sethupathy   +10 more
doaj   +1 more source

miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease

Molecular Medicine, 2019
Non-alcoholic fatty liver disease (NAFLD) is a common hepatic disease with an increasing prevalence but an unclear aetiology. This study aimed to investigate the functional implications of microRNA-122 (miR-122) in the pathogenesis of NAFLD and the ...
J. Long, W. Dai, Yanling Zheng, Shuiping Zhao   +3 more
semanticscholar   +1 more source

Knocking out central metabolism genes to identify new targets and alternating substrates to improve lipid synthesis in Y. lipolytica

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Systematic gene knockout studies may offer us novel insights on cell metabolism and physiology. Specifically, the lipid accumulation mechanism at the molecular or cellular level is yet to be determined in the oleaginous yeast Y.
Jiang Zhu, Yang Gu, Yang Gu, Yijing Yan, Jingbo Ma, Jingbo Ma, Xiaoman Sun, Peng Xu, Peng Xu, Peng Xu   +9 more
doaj   +1 more source

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Nature Communications, 2020
Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance.
K. Roumans, L. Lindeboom, Pandichelvam Veeraiah, Carlijn M. E. Remie, E. Phielix, B. Havekes, Y. Bruls, M. Brouwers, M. Ståhlman, M. Alssema, H. Peters, R. de Mutsert, B. Staels, M. Taskinen, J. Borén, P. Schrauwen, V. Schrauwen-Hinderling   +16 more
semanticscholar   +1 more source

Engineering Kluyveromyces marxianus as a Robust Synthetic Biology Platform Host

mBio, 2018
Throughout history, the yeast Saccharomyces cerevisiae has played a central role in human society due to its use in food production and more recently as a major industrial and model microorganism, because of the many genetic and genomic tools available ...
Paul Cernak, Raissa Estrela, Snigdha Poddar, Jeffrey M. Skerker, Ya-Fang Cheng, Annika K. Carlson, Berling Chen, Victoria M. Glynn, Monique Furlan, Owen W. Ryan, Marie K. Donnelly, Adam P. Arkin, John W. Taylor, Jamie H. D. Cate   +13 more
doaj   +1 more source