Results 81 to 90 of about 144,905 (388)
Scientific Reports, 2018 Obesity is associated with a disturbed adipose tissue (AT) function characterized by adipocyte hypertrophy, an impaired lipolysis and pro-inflammatory phenotype, which contributes to insulin resistance (IR).
K. Verboven +11 more
semanticscholar +1 more source
Advanced Materials, EarlyView.Adipocyte membrane‐coated nanoparticles loaded with rosiglitazone in hydrogel offer an alternative approach to conventional obesity treatments. This system selectively targets adipocytes, inducing lipolysis by activating chaperone‐mediated autophagy through mild photothermal stimulation.
Jaehyun Choi +8 more
wiley +1 more source
Dissection of surface area-dependent lipolysis at a single organelle level
Cell ReportsSummary: Lipid droplets are dynamic organelles whose size and number signify their role in energy. However, owing to cellular heterogeneity and technological limitations, the relationship between the lipolytic ability and lipid droplet morphology is ...
Chengxin Ma +9 more
doaj +1 more source
Frontiers in Oncology, 2022 Adipose tissue inflammation is observed in multiple metabolically-altered states including cancer-associated cachexia and obesity. Although cachexia is a syndrome of adipose loss and obesity is a disease of adipose excess, both pathologies demonstrate ...
Aakash Y. Gandhi +14 more
doaj +1 more source
The Effect of a Reduced-Calorie Diet on alpha-2 Adrenergic Receptor Responsiveness in Abdominal Adipose Tissue in Obese Men During Exercise [PDF]
, 2008 There is at present an imperfect understanding of the effect of diet on availability of inhibitory receptors in fat cells during exercise among obese men. *Objective:* The purpose of this study was to determine whether diet results in
David Turbow +3 more
core +1 more source
Advanced Science, EarlyView.This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen +9 more
wiley +1 more source
Redox Regulation of Lipid Mobilization in Adipose Tissues
Antioxidants, 2021 Lipid mobilization in adipose tissues, which includes lipogenesis and lipolysis, is a paramount process in regulating systemic energy metabolism.
Ursula Abou-Rjeileh, G. Andres Contreras
doaj +1 more source
Circulating free fatty acids, insulin, and glucose during chemical stimulation of hypothalamus in rats [PDF]
, 1984 The aim of this study was to investigate plasma free fatty acids (FFA), insulin, and blood glucose during chemical stimulation of the lateral and ventromedial hypothalamic areas (LHA and VMH) in rats.
Damsma, G., +3 more
core +1 more source
Lipids in Health and Disease, 2018 Cancer cachexia is a progressive and multi-factorial metabolic syndrome characterized by loss of adipose tissue and skeletal muscle. White adipose tissue (WAT) lipolysis and white-to-brown transdifferentiation of WAT (WAT browning) are proposed to ...
Jun Han, Q. Meng, Lei Shen, Guohao Wu
semanticscholar +1 more source
Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice
Advanced Science, EarlyView.Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia +29 more
wiley +1 more source