Results 91 to 100 of about 29,837 (216)

Drug Product Development of Lipid Nanoparticle‐Based mRNA Therapeutics and Vaccines

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Overview of the development path from an mRNA–lipid nanoparticle (LNP) concept to a licensed drug product, covering LNP design, manufacturing process development, formulation, and analytical characterization. ABSTRACT Lipid nanoparticles (LNP) are currently the most relevant non‐viral delivery systems for mRNA and occasionally for smaller nucleic acids
Gideon Kersten, Eleonora Cerasoli, Bruce Kerwin, Olivia M. Merkel, Andrea Hawe   +4 more
wiley   +1 more source

Dysbiosis in the Pathogenesis of Atopic Dermatitis

The Journal of Dermatology, Volume 53, Issue 3, Page 388-398, March 2026.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by epidermal barrier dysfunction and immune dysregulation. Recent research highlights cutaneous dysbiosis as a critical factor in its pathogenesis. In this review, we summarize the interplay between the skin microbiota and host immunity, contrasting the homeostatic ...
Hiroki Okamoto, Yuumi Nakamura
wiley   +1 more source

Lipopeptides: Biosynthesis and Applications [PDF]

Journal of Microbial & Biochemical Technology, 2015
Microbial surfactants are amphiphilic molecules. They possess a strong tendency to reduce the interfacial tension among compounds. Biosurfactants possess diverse chemical structures and are nontoxic and hence are biodegradable. They have many applications in bioremediation, enhanced oil recovery, pharmaceutical and in food industry.
openaire   +1 more source

Biofilm Associated Persistence and Drug Tolerance in Mycobacteria Within Host Microenvironments

APMIS, Volume 134, Issue 3, March 2026.
ABSTRACT Biofilms formed by mycobacteria, particularly Mycobacterium tuberculosis (Mtb), represent a major challenge in tuberculosis (TB) treatment due to their highly organized structure and their capacity to induce phenotypic drug tolerance. These three‐dimensional bacterial aggregates are embedded in a self‐produced extracellular matrix that ...
Lourdes Serrano Garcia, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan, Marlus Chorilli   +3 more
wiley   +1 more source

Mitophagy and Bip–PERK–eIF2α–ATF4 Axis‐Mediated ER Stress Mediate Miriplatin‐Loaded Liposome's Anti‐Colorectal Cancer Action

Cell Proliferation, Volume 59, Issue 3, March 2026.
LMPt enters the cell mainly through caveolin‐mediated endocytosis, and then fuses with endosomes and lysosomes to deliver MPt to mitochondria and the endoplasmic reticulum to induce mitophagy based on the fusion of lysosomes and mitochondria, and endoplasmic reticulum stress and subsequent apoptosis via the Bip–PERK–eIF2α–ATF4 axis to exert an anti ...
Cong Zhao, Yuhan Qiu, Xiaowei Wang, Mengyan Wang, Li Liu, Xiaojun Zhao, Zixiang Gao, Rongguang Shao, Guimin Xia, Wuli Zhao   +9 more
wiley   +1 more source

Insight into Antifungal Metabolites from Bacillus stercoris 92p Against Banana Cordana Leaf Spot Caused by Neocordana musae

Biomolecules
Banana crop ranks among the most crucial fruit and food crops in tropical and subtropical areas. Despite advancements in production technology, diseases such as cordana leaf spot, caused by Neocordana musae, remain a significant challenge, reducing ...
Qunfang Yu, Pengbo He, Yanxiang Qi, Pengfei He, Ayesha Ahmed, Xin Zhang, He Zhang, Yixin Wu, Shahzad Munir, Yueqiu He   +9 more
doaj   +1 more source

Monotherapy with a low-dose lipopeptide HIV fusion inhibitor maintains long-term viral suppression in rhesus macaques

PLoS Pathogens, 2019
Combination antiretroviral therapy (cART) dramatically improves survival of HIV-infected patients, but lifelong treatment can ultimately result in cumulative toxicities and drug resistance, thus necessitating the development of new drugs with ...
Huihui Chong, Jing Xue, Yuanmei Zhu, Z. Cong, Ting Chen, Q. Wei, C. Qin, Yuxian He   +7 more
semanticscholar   +1 more source

Structure of the lipopeptide antibiotic tsushimycin

Acta Crystallographica Section D Biological Crystallography, 2005
The amphomycin derivative tsushimycin has been crystallized and its structure determined at 1.0 A resolution. The asymmetric unit contains 12 molecules and with 1300 independent atoms this structure is one of the largest solved using ab initio direct methods.
Bunkoczi, G., Vertesy, L., Sheldrick, George M.   +2 more
openaire   +3 more sources

Mechanistic Insights for Microbiome Application in Plant Disease Resistance

Molecular Plant Pathology, Volume 27, Issue 3, March 2026.
This review summarises the mechanisms underlying plant‐guided microbiome modulation and probiotic‐mediated disease suppression. Additionally, it highlights the challenges to be addressed for a better microbiome application of disease resistance in sustainable agriculture and proposes possible strategies. Figure was created with BioRender.
Jiakang Yin
wiley   +1 more source

The effect of Biokos™, a natural lipopeptide surfactant extracted from the bacterium Pseudomonas, on Epistylis infections in Carassius auratus [PDF]

Revista Brasileira de Parasitologia Veterinária
In the aquaculture industry, biocides are routinely used to treat parasitosis in fish, and researchers are continually developing sustainable alternatives that can replace these harsh chemicals.
Gabriela Cavalante Maciel, Simone de Carvalho Balian, Herbert Sousa Soares, Maurício Laterça Martins, Giovanni Salerno, Malte Jarlgaard Hansen, Pedro Henrique Magalhães Cardoso   +6 more
doaj   +1 more source