Results 71 to 80 of about 38,790 (251)

Mitophagy and Bip–PERK–eIF2α–ATF4 Axis‐Mediated ER Stress Mediate Miriplatin‐Loaded Liposome's Anti‐Colorectal Cancer Action

Cell Proliferation, EarlyView.
LMPt enters the cell mainly through caveolin‐mediated endocytosis, and then fuses with endosomes and lysosomes to deliver MPt to mitochondria and the endoplasmic reticulum to induce mitophagy based on the fusion of lysosomes and mitochondria, and endoplasmic reticulum stress and subsequent apoptosis via the Bip–PERK–eIF2α–ATF4 axis to exert an anti ...
Cong Zhao, Yuhan Qiu, Xiaowei Wang, Mengyan Wang, Li Liu, Xiaojun Zhao, Zixiang Gao, Rongguang Shao, Guimin Xia, Wuli Zhao   +9 more
wiley   +1 more source

Lipid- and sugar-modified endomorphins: Novel targets for the treatment of neuropathic pain

Frontiers in Pharmacology, 2013
Endomorphins are endogenous opioid peptides that cause potent antinociception in rodent models of acute and neuropathic pain with less undesirable side effects than opioid alkaloids.
Pegah eVaramini, Istvan eToth, Istvan eToth   +2 more
doaj   +1 more source

Antagonistic effect of rhizospheric bacteria against white rot (Sclerotium cepivorum) of garlic (Allium sativum L.) under in vitro and in vivo conditions

Agrosystems, Geosciences &Environment, Volume 9, Issue 1, March 2026.
Abstract Garlic (Allium sativum), a vegetable crop used for food, medicine, and condiments, is affected by white rot (Sclerotium cepivorum). Garlic yield reduction is influenced by several factors, with biotic stresses, particularly fungal pathogens, being among the most significant.
Mussa Adal Mohammed, Asmare Dejen Demeke
wiley   +1 more source

Lipopeptide-mediated Cas9 RNP delivery: A promising broad therapeutic strategy for safely removing deep-intronic variants in ABCA4

Molecular Therapy: Nucleic Acids
Deep-intronic (DI) variants represent approximately 10%–12% of disease-causing genetic defects in ABCA4-associated Stargardt disease (STGD1). Although many of these DI variants are amenable to antisense oligonucleotide-based splicing-modulation therapy ...
Irene Vázquez-Domínguez, Mert Öktem, Florian A. Winkelaar, Thai Hoang Nguyen, Anita D.M. Hoogendoorn, Eleonora Roschi, Galuh D.N. Astuti, Raoul Timmermans, Nuria Suárez-Herrera, Ilaria Bruno, Albert Ruiz-Llombart, Joseph Brealey, Olivier G. de Jong, Rob W.J. Collin, Enrico Mastrobattista, Alejandro Garanto   +15 more
doaj   +1 more source

Inhibitory Effect of Bacillus velezensis dhm2 on Fusarium oxysporum f. sp. cucumerinum and Synergistic Activity of Crude Lipopeptide Extract with Chemical Fungicides

Agriculture
Fusarium oxysporum f. sp. cucumerium, a resilient saprophytic fungus, poses a significant risk to cucumber crops. The research investigated the suppressive impact of Bacillus velezensis dhm2 on this pathogen and the synergistic performance of its crude ...
Xinyu He, Haiming Duan, Xingyu Liu, Zhuangzhuang Li, Li Yu, Cheng Zhou, Wenjie Lu, Haibing Yu   +7 more
doaj   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Pass-back chain extension expands multimodular assembly line biosynthesis. [PDF]

, 2020
Modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzymatic assembly lines are large and dynamic protein machines that generally effect a linear sequence of catalytic cycles.
Huan, Tao, Moore, Bradley S, Ross, Avena C, Tang, Xiaoyu, Tang, Xiaoyu, Zhang, Jia Jia   +5 more
core  

Self-assembly of the toll-like receptor agonist macrophage-activating lipopeptide MALP-2 and of its constituent peptide [PDF]

, 2016
The self-assembly of the macrophage-activating lipopeptide MALP-2 in aqueous solution has been investigated and is compared to that of the constituent peptide GNNDESNISFKEK.
Bellamy L. J., Creighton T. E., Ian W. Hamley, Janne Ruokolainen, LeVine H., Martin Rabe, Mehedi Reza, Nordén B., Radoslaw Kowalczyk, Shnyra A., Sreerama N., Steven Kirkham, Stuart B., Takayama K., Takayama K., Toniolo C., Valeria Castelletto   +16 more
core   +2 more sources

Biosurfactants produced by marine microorganisms with therapeutic applications [PDF]

, 2016
Marine microorganisms possess unique metabolic and physiological features and are an important source of new biomolecules, such as biosurfactants. Some of these surface-active compounds synthesized by marine microorganisms exhibit antimicrobial, anti ...
Eduardo Gudiña, Felczykowska, Fracchia, Fuji, Hamed, José Teixeira, Karanth, Lígia Rodrigues, Nuñez, Park, Poremba, Ramiah, Rodrigues, Sen, Stein, Xie   +15 more
core   +5 more sources

Advancements and Challenges in the Production of Biosurfactants: A Path Toward Sustainable Surfactant Alternatives

ChemBioEng Reviews, Volume 13, Issue 1, February 2026.
Microorganisms generate versatile biosurfactants with a wide range of uses. Although cost issues still exist, industrial interest is growing because to the advantages of sustainability, which are enhanced by genetic engineering; life cycle evaluation is crucial for scalable, environmentally responsible production.
Lavanya M., Rishabh Agarwala
wiley   +1 more source