Results 71 to 80 of about 16,028 (215)
Drug Product Development of Lipid Nanoparticle‐Based mRNA Therapeutics and Vaccines
WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.Overview of the development path from an mRNA–lipid nanoparticle (LNP) concept to a licensed drug product, covering LNP design, manufacturing process development, formulation, and analytical characterization. ABSTRACT Lipid nanoparticles (LNP) are currently the most relevant non‐viral delivery systems for mRNA and occasionally for smaller nucleic acids
Gideon Kersten +4 more
wiley +1 more source
Dysbiosis in the Pathogenesis of Atopic Dermatitis
The Journal of Dermatology, Volume 53, Issue 3, Page 388-398, March 2026.ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by epidermal barrier dysfunction and immune dysregulation. Recent research highlights cutaneous dysbiosis as a critical factor in its pathogenesis. In this review, we summarize the interplay between the skin microbiota and host immunity, contrasting the homeostatic ...
Hiroki Okamoto, Yuumi Nakamura
wiley +1 more source
Biofilm Associated Persistence and Drug Tolerance in Mycobacteria Within Host Microenvironments
APMIS, Volume 134, Issue 3, March 2026.ABSTRACT Biofilms formed by mycobacteria, particularly Mycobacterium tuberculosis (Mtb), represent a major challenge in tuberculosis (TB) treatment due to their highly organized structure and their capacity to induce phenotypic drug tolerance. These three‐dimensional bacterial aggregates are embedded in a self‐produced extracellular matrix that ...
Lourdes Serrano Garcia +3 more
wiley +1 more source
Lipopeptides: Biosynthesis and Applications [PDF]
Journal of Microbial & Biochemical Technology, 2015 Microbial surfactants are amphiphilic molecules. They possess a strong tendency to reduce the interfacial tension among compounds. Biosurfactants possess diverse chemical structures and are nontoxic and hence are biodegradable. They have many applications in bioremediation, enhanced oil recovery, pharmaceutical and in food industry.
openaire +1 more source
Cell Proliferation, Volume 59, Issue 3, March 2026.LMPt enters the cell mainly through caveolin‐mediated endocytosis, and then fuses with endosomes and lysosomes to deliver MPt to mitochondria and the endoplasmic reticulum to induce mitophagy based on the fusion of lysosomes and mitochondria, and endoplasmic reticulum stress and subsequent apoptosis via the Bip–PERK–eIF2α–ATF4 axis to exert an anti ...
Cong Zhao +9 more
wiley +1 more source
Nutrition & Santé, 2016 Since the end of the 20th century, the efforts regarding the environment protection have been increasingly intensified. As most of surfactants used at present arise from the chemical industry, the search for new biological surfactants or biosurfactants ...
Hanen BEN AYED, Moncef NASRI
doaj
Mechanistic Insights for Microbiome Application in Plant Disease Resistance
Molecular Plant Pathology, Volume 27, Issue 3, March 2026.This review summarises the mechanisms underlying plant‐guided microbiome modulation and probiotic‐mediated disease suppression. Additionally, it highlights the challenges to be addressed for a better microbiome application of disease resistance in sustainable agriculture and proposes possible strategies. Figure was created with BioRender.
Jiakang Yin
wiley +1 more source
Structure of the lipopeptide antibiotic tsushimycin
Acta Crystallographica Section D Biological Crystallography, 2005 The amphomycin derivative tsushimycin has been crystallized and its structure determined at 1.0 A resolution. The asymmetric unit contains 12 molecules and with 1300 independent atoms this structure is one of the largest solved using ab initio direct methods.
Bunkoczi, G. +2 more
openaire +3 more sources
Production of lipopeptide biosurfactants by Bacillus atrophaeus 5-2a and their potential use in microbial enhanced oil recovery [PDF]
, 2016 Junhui Zhang +4 more
openalex +1 more source
Frontiers in Microbiology, 2019 Within the framework of biocontrol development, three natural substances produced by Bacillus subtilis, called lipopeptides, have been studied: fengycin (F), surfactin (S), and mycosubtilin (M). Their antifungal properties were tested in vitro, in liquid
Hélène Desmyttere +6 more
doaj +1 more source