Results 91 to 100 of about 7,072 (199)

ATG14 targets lipid droplets and acts as an autophagic receptor for syntaxin18-regulated lipid droplet turnover

Nature Communications
Lipid droplets (LDs) are dynamic lipid storage organelles that can be degraded by autophagy machinery to release neutral lipids, a process called lipophagy. However, specific receptors and regulation mechanisms for lipophagy remain largely unknown. Here,
Zhen Yuan, Kun Cai, Jiajia Li, Ruifeng Chen, Fuhai Zhang, Xuan Tan, Yaming Jiu, Haishuang Chang, Bing Hu, Weiyi Zhang, Binbin Ding   +10 more
doaj   +1 more source

A Supramolecular Nanoscavengers: Based “Cargo‐Exchange” Breaking Cholesterol Metabolic Dysregulation for Glioblastoma Therapy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Dysregulated cholesterol metabolism, driven by a complex array of mechanisms, is a defining characteristic of glioblastoma (GBM). In this study, supramolecular nanoscavengers are engineered by harnessing the intrinsic binding affinity between endogenous small‐molecule cholesterol and β‐cyclodextrin (β‐CD).
Zonghua Tian, Yun Chen, Jingyi Zhou, Shilin Zhang, Hongrui Fan, Xuwen Li, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Lipophagy: A New Perspective of Natural Products in Type 2 Diabetes Mellitus Treatment

Diabetes, Metabolic Syndrome and Obesity, 2021
Mingyue Huang,1,2,* Xinyu Yang,2,* Zhenzhen Wang,3 Jianglan Long,3 Aiting Wang,3 Yi Zhang,4 Dan Yan3 1College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, People’s Republic of China; 2Beijing Key Laboratory of
Huang M, Yang X, Wang Z, Long J, Wang A, Zhang Y, Yan D   +6 more
doaj  

Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor [PDF]

, 2018
Lysosomes have an important role in cellular protein and organelle quality control, metabolism, and signaling. On the surface of lysosomes, the PIKfyve/Fab1 complex generates phosphatidylinositol 3,5-bisphosphate, PI-3,5-P2, which is critical for ...
Stefan, CJ
core   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, Volume 108, Issue 2, Page 676-693, February 2026.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

MiR-223 enhances lipophagy by suppressing CTSB in microglia following lysolecithin-induced demyelination in mice

Lipids in Health and Disease
Background Lipid droplet (LD)-laden microglia is a key pathological hallmark of multiple sclerosis. The recent discovery of this novel microglial subtype, lipid-droplet-accumulating microglia (LDAM), is notable for increased inflammatory factor secretion
Hao Ma, Zhi-lin Ou, Nima Alaeiilkhchi, Yong-quan Cheng, Kai Chen, Jia-yu Chen, Ru-qin Guo, Min-yue He, Shi-yi Tang, Xin Zhang, Zhi-ping Huang, Junhao Liu, Jie Liu, Qing-an Zhu, Zu-cheng Huang, Hui Jiang   +15 more
doaj   +1 more source

Glutathione Decrement Drives Thermogenic Program in Adipose Cells [PDF]

, 2015
Adipose tissue metabolically adapts to external stimuli. We demonstrate that the induction of the thermogenic program in white adipocytes, through cold exposure in mice or in vitro adrenergic stimulation, is accompanied by a decrease in the intracellular
Aquilano, K, Bernardini, S, Cannata, S, Ciriolo, MR, Lettieri Barbato, D, Tatulli, G   +5 more
core   +1 more source

Truncal Acne: Pathophysiology, Clinical Features, and Management Strategies

Journal of Cosmetic Dermatology, Volume 25, Issue 2, February 2026.
ABSTRACT Background Truncal acne is common but underrecognized. Its pathogenesis is often considered similar to facial acne, so most studies and guidelines focus on facial involvement despite the substantial disease burden of truncal lesions. Objective This narrative review compares structural and physiological differences between truncal and facial ...
Xiaoyue Feng, Yong Chen, Youting Liu
wiley   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, Volume 600, Issue 2, Page 140-163, January 2026.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy

Journal of the American Heart Association, 2017
Background Compromised lipophagy with unknown mechanisms may be critically involved in the intracellular accumulation of lipids, contributing to elevated atherosclerosis and liver steatosis. We hypothesize that toll‐interacting protein (Tollip), a key innate immune molecule involved in the fusion of autolysosome, may play a ...
Chen, Keqiang, Yuan, Ruoxi, Zhang, Yao, Geng, Shuo, Li, Liwu   +4 more
openaire   +4 more sources