Results 91 to 100 of about 6,907 (199)

Lipid Droplet Formation and Lipophagy in Fatty Liver Disease [PDF]

Seminars in Liver Disease, 2019
AbstractLipid droplets (LDs) are key sites of neutral lipid storage that can be found in all cells. Metabolic imbalances between the synthesis and degradation of LDs can result in the accumulation of significant amounts of lipid deposition, a characteristic feature of hepatocytes in patients with fatty liver disease, a leading indication for liver ...
Ryan J, Schulze, Mark A, McNiven
openaire   +2 more sources

ATG14 targets lipid droplets and acts as an autophagic receptor for syntaxin18-regulated lipid droplet turnover

Nature Communications
Lipid droplets (LDs) are dynamic lipid storage organelles that can be degraded by autophagy machinery to release neutral lipids, a process called lipophagy. However, specific receptors and regulation mechanisms for lipophagy remain largely unknown. Here,
Zhen Yuan, Kun Cai, Jiajia Li, Ruifeng Chen, Fuhai Zhang, Xuan Tan, Yaming Jiu, Haishuang Chang, Bing Hu, Weiyi Zhang, Binbin Ding   +10 more
doaj   +1 more source

Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor [PDF]

, 2018
Lysosomes have an important role in cellular protein and organelle quality control, metabolism, and signaling. On the surface of lysosomes, the PIKfyve/Fab1 complex generates phosphatidylinositol 3,5-bisphosphate, PI-3,5-P2, which is critical for ...
Stefan, CJ
core   +1 more source

Lipophagy: A New Perspective of Natural Products in Type 2 Diabetes Mellitus Treatment

Diabetes, Metabolic Syndrome and Obesity, 2021
Mingyue Huang,1,2,* Xinyu Yang,2,* Zhenzhen Wang,3 Jianglan Long,3 Aiting Wang,3 Yi Zhang,4 Dan Yan3 1College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, People’s Republic of China; 2Beijing Key Laboratory of
Huang M, Yang X, Wang Z, Long J, Wang A, Zhang Y, Yan D   +6 more
doaj  

Glutathione Decrement Drives Thermogenic Program in Adipose Cells [PDF]

, 2015
Adipose tissue metabolically adapts to external stimuli. We demonstrate that the induction of the thermogenic program in white adipocytes, through cold exposure in mice or in vitro adrenergic stimulation, is accompanied by a decrease in the intracellular
Aquilano, K, Bernardini, S, Cannata, S, Ciriolo, MR, Lettieri Barbato, D, Tatulli, G   +5 more
core   +1 more source

β‐Hydroxybutyrate Acts as an Exercise Mimetic to Protect the Aging Liver

Aging Cell, Volume 25, Issue 1, January 2026.
β‐hydroxybutyrate (β‐HB) acts as an exercise mimetic to protect the aging liver. In aged models, exercise‐induced β‐HB delays liver aging by reversing macrophage senescence, blocking mtDNA/cGAS‐STING‐driven inflammation, and alleviating hepatocyte lipid deposition/PANoptosis.
Ke Li, Lian Wang, Danlin Zhu, Wenhong Wang, Yifan Guo, Haoyang Gao, Muge Zhou, Weihua Xiao   +7 more
wiley   +1 more source

PLIN3-triggered lipophagic flux releases FFAs to facilitate CSFV propagation

Virulence
Viruses hijack host metabolic resources for replication. Previous studies have shown that classical swine fever virus (CSFV) infection induces host lipid metabolic reprogramming.However, research into the exact regulatory mechanisms between CSFV and ...
Bingke Li, Linke Zou, Chenchen Sun, Jianan Jiang, Shurou Li, Jiaxin Wang, Yintao He, Yuwei Qin, Sen Zeng, Yiwan Song, Weijun Zeng, Lin Yi, Shuangqi Fan, Jinding Chen, Keke Wu   +14 more
doaj   +1 more source

Health Benefits and Therapeutic Potential of Quercetin

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley   +1 more source

Natural Products as Potential Resource Library for Control of Major Swine Enteric Viruses

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Major swine enteric viruses (SEVs), including porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), swine acute diarrhea syndrome coronavirus (SADS‐CoV), and porcine rotavirus (PoRV), cause severe gastrointestinal diseases in pigs, leading to huge economic losses to the swine industry ...
Jialu Zhang, Yuqian Liu, Shuying Ren, Zhouyuan Wang, Yunxia Li, Lianci Peng, Rendong Fang, Jianchao Wei   +7 more
wiley   +1 more source

IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

Cell Reports, 2019
Summary: Autophagy plays a broad role in health and disease. Here, we show that inositol polyphosphate multikinase (IPMK) is a prominent physiological determinant of autophagy and is critical for liver inflammation and regeneration.
Prasun Guha, Richa Tyagi, Sayan Chowdhury, Luke Reilly, Chenglai Fu, Risheng Xu, Adam C. Resnick, Solomon H. Snyder   +7 more
doaj   +1 more source