Results 101 to 110 of about 6,907 (199)
Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy
Journal of the American Heart Association, 2017 Background Compromised lipophagy with unknown mechanisms may be critically involved in the intracellular accumulation of lipids, contributing to elevated atherosclerosis and liver steatosis. We hypothesize that toll‐interacting protein (Tollip), a key innate immune molecule involved in the fusion of autolysosome, may play a ...
Chen, Keqiang +4 more
openaire +4 more sources
Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance [PDF]
, 2014 Macroautophagy (autophagy hereafter) recycles intracellular components to sustain mitochondrial metabolism that promotes the growth, stress tolerance, and malignancy of lung cancers, suggesting that autophagy inhibition may have antitumor activity.
Chan, Chang S. +10 more
core +2 more sources
Lipids in Health and DiseaseBackground Lipid droplet (LD)-laden microglia is a key pathological hallmark of multiple sclerosis. The recent discovery of this novel microglial subtype, lipid-droplet-accumulating microglia (LDAM), is notable for increased inflammatory factor secretion
Hao Ma +15 more
doaj +1 more source
Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization. [PDF]
, 2014 We have previously demonstrated that Stat3 regulates lysosomal-mediated programmed cell death (LM-PCD) during mouse mammary gland involution in vivo. However, the mechanism that controls the release of lysosomal cathepsins to initiate cell death in this ...
A Fontana +65 more
core +3 more sources
Autophagy in the light of sphingolipid metabolism [PDF]
, 2015 Maintenance of cellular homeostasis requires tight and coordinated control of numerous metabolic pathways, which are governed by interconnected networks of signaling pathways and energy-sensing regulators.
Færgeman, Nils J. +2 more
core +2 more sources
Microlipophagy from Simple to Complex Eukaryotes
CellsLipophagy is a selective degradation of lipid droplets in lysosomes or vacuoles. Apart from its role in generating energy and free fatty acids for membrane repair, growth, and the formation of new membranes, lipophagy emerges as a key player in other ...
Ravinder Kumar +3 more
doaj +1 more source
All-trans retinoic acid induces lipophagy by reducing Rubicon in Hepa1c1c7 cells
Journal of Lipid ResearchAll-trans retinoic acid (atRA), a metabolite of vitamin A, reduces hepatic lipid accumulation in liver steatosis model animals. Lipophagy, a new lipolysis pathway, degrades a lipid droplet (LD) via autophagy in adipose tissue and the liver.
Anh The Nguyen +12 more
doaj +1 more source
Viral hijacking of cellular metabolism. [PDF]
, 2019 This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate.
Ch'ng, James +2 more
core
Neuronal Proteomic Analysis Of The Ubiquitinated Substrates Of The Disease-Linked E3 Ligases Parkin And Ube3a [PDF]
, 2018 Both Parkin and UBE3A are E3 ubiquitin ligases whose mutations result in severe brain dysfunction. Several of their substrates have been identified using cell culture models in combination with proteasome inhibitors, but not in more physiological ...
Arizmendi Bastarrika, Jesús María +4 more
core +4 more sources
Targeting Adipose Tissue Lipid Metabolism to Improve Glucose Metabolism in Cardiometabolic Disease [PDF]
European Medical Journal Diabetes, 2014 With Type 2 diabetes mellitus and cardiovascular disease prevalence on the rise, there is a growing need for improved strategies to prevent or treat obesity and insulin resistance, both of which are major risk factors for these chronic diseases ...
Johan W.E. Jocken +2 more
doaj