Results 101 to 110 of about 7,072 (199)

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance [PDF]

, 2014
Macroautophagy (autophagy hereafter) recycles intracellular components to sustain mitochondrial metabolism that promotes the growth, stress tolerance, and malignancy of lung cancers, suggesting that autophagy inhibition may have antitumor activity.
Chan, Chang S., Guo, Jessie Yanxiang, Jacks, Tyler E, Kalaany, Nada Y., Karsli-Uzunbas, Gizem, Khor, Sinan, Laddha, Saurabh V., Price, Sandy, Rabinowitz, Joshua D., Teng, Xin, White, Eileen   +10 more
core   +2 more sources

IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

Cell Reports, 2019
Summary: Autophagy plays a broad role in health and disease. Here, we show that inositol polyphosphate multikinase (IPMK) is a prominent physiological determinant of autophagy and is critical for liver inflammation and regeneration.
Prasun Guha, Richa Tyagi, Sayan Chowdhury, Luke Reilly, Chenglai Fu, Risheng Xu, Adam C. Resnick, Solomon H. Snyder   +7 more
doaj   +1 more source

Microlipophagy from Simple to Complex Eukaryotes

Cells
Lipophagy is a selective degradation of lipid droplets in lysosomes or vacuoles. Apart from its role in generating energy and free fatty acids for membrane repair, growth, and the formation of new membranes, lipophagy emerges as a key player in other ...
Ravinder Kumar, Colin Arrowood, Micah B. Schott, Taras Y. Nazarko   +3 more
doaj   +1 more source

Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans [PDF]

, 2017
Starvationcauses comprehensivemetabolicchanges, which are still not fully understood. Here, we used quantitative proteomics and RNA sequencing to examine the temporal starvation responses in wildtype Caenorhabditis elegans and animals lacking the ...
Angelo, Azimifar, Barcia, Bjellqvist, Bjellqvist, Blumenthal, Brenner, Brosch, Cuervo, DePina, Depuydt, Dhondt, Dobin, Dong, Elle, Fredens, Grove, Grun, Hansen, Heestand, Heinz, Hojrup, Huang da, Huang da, Kang, Kent, Kent, Kim, Kimble, Lapierre, Larance, Larance, Larance, Leon, Liang, Liu, Ly, Ma, Magini, Maier, Murphy, Murtagh, Narayan, Narbonne, O'Rourke, Palgunow, Pang, Pena-Llopis, Robinson, Roczniak-Ferguson, Schaftenaar, Schwammle, Seah, Settembre, Settembre, Silva, Simonsen, Spivak, Tetlak, Van Rompay, Visscher, Visvikis, Vogel, Walther, Wang, Wilkins, Yang, Zimmerman   +67 more
core   +3 more sources

Viral hijacking of cellular metabolism. [PDF]

, 2019
This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate.
Ch'ng, James, Christofk, Heather R, Thaker, Shivani K   +2 more
core  

Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization. [PDF]

, 2014
We have previously demonstrated that Stat3 regulates lysosomal-mediated programmed cell death (LM-PCD) during mouse mammary gland involution in vivo. However, the mechanism that controls the release of lysosomal cathepsins to initiate cell death in this ...
A Fontana, Antonio Ramos-Montoya, Bethan Lloyd-Lewis, C Manzoni, Christine J. Watson, CJ Luke, CJ Watson, CJ Watson, CJ Watson, DJ Klionsky, E Bournazou, E Reichmann, G Kroemer, H Jespersen, Henrike K. Resemann, HJ Helminen, I Hara-Nishimura, I Mather, J Huai, J Jeong, J Monks, J-S Silvestre, Jeremy Skepper, JF Kerr, JP Luzio, K Atabai, K Hughes, K Kågedal, K Ono, L Foghsgaard, L Galluzzi, L Jahreiss, L Yuzefovych, LC Gomes, LL Listenberger, LR Lund, M Merkel, NV Margaryan, O Vasiljeva, P Kreuzaler, P Rammer, PA Kreuzaler, R Clarkson, R Hanayama, R Singh, R Zaragoza, RA Lockshin, RA Lockshin, RC Humphreys, RH Unger, RS Chapman, S Aits, S Cornillon, S Selbert, S Smith, SL Ogg, SS Kitambi, T Alonzi, T Kallunki, T Kirkegaard, Timothy J. Sargeant, TM Cox, U Becken, W Roth, WA Maltese, WG vanDoorn   +65 more
core   +3 more sources

Autophagy in the light of sphingolipid metabolism [PDF]

, 2015
Maintenance of cellular homeostasis requires tight and coordinated control of numerous metabolic pathways, which are governed by interconnected networks of signaling pathways and energy-sensing regulators.
Færgeman, Nils J., Harvald, Eva Bang, Olsen, Anne Sofie Braun   +2 more
core   +2 more sources

All-trans retinoic acid induces lipophagy by reducing Rubicon in Hepa1c1c7 cells

Journal of Lipid Research
All-trans retinoic acid (atRA), a metabolite of vitamin A, reduces hepatic lipid accumulation in liver steatosis model animals. Lipophagy, a new lipolysis pathway, degrades a lipid droplet (LD) via autophagy in adipose tissue and the liver.
Anh The Nguyen, Masashi Masuda, Yuki Mori, Yuichiro Adachi, Teppei Fukuda, Airi Furuichi, Masaki Takikawa, Yuki Tsuda, Yuki Hamada, Yusuke Maruyama, Hirokazu Ohminami, Kohta Ohnishi, Yutaka Taketani   +12 more
doaj   +1 more source

Targeting Adipose Tissue Lipid Metabolism to Improve Glucose Metabolism in Cardiometabolic Disease [PDF]

European Medical Journal Diabetes, 2014
With Type 2 diabetes mellitus and cardiovascular disease prevalence on the rise, there is a growing need for improved strategies to prevent or treat obesity and insulin resistance, both of which are major risk factors for these chronic diseases ...
Johan W.E. Jocken, Gijs H. Goossens, Ellen E. Blaak   +2 more
doaj  

The mammalian ULK1 complex and autophagy initiation [PDF]

, 2017
Autophagy is a vital lysosomal degradation pathway that serves as a quality control mechanism. It rids the cell of damaged, toxic or excess cellular components, which if left to persist could be detrimental to the cell.
Bach, Bento, Chan, Chan, Chauhan, Chen, Cheong, Chude, Di Bartolomeo, Dunlop, Egan, Egan, Farre, Fullgrabe, Gammoh, Gan, Gan, Ganley, Henckaerts, Hieke, Hosokawa, Hosokawa, Ian G. Ganley, Itakura, James T. Murray, Jiang, Jon D. Lane, Joo, Jung, Kaizuka, Kaizuka, Karanasios, Karanasios, Kim, Konno, Koyama-Honda, Kundu, Lamark, Lazarou, Lazarus, Lee, Li, Li, Li, Li, Lim, Lin, Lin, Liu, Liu, Maria Zachari, McWilliams, Mercer, Nazio, Nazio, Ochaba, Orsi, Pengo, Petherick, Pickrell, Pike, Puente, Puri, Qi, Rabanal-Ruiz, Rui, Russell, Sarraf, Schneider, Sellier, Su, Sun, Suzuki, Tian, Torii, Ugolino, Viktor I. Korolchuk, Wang, Webster, Wold, Wong, Wu, Xu, Yang, Young, Yun, Zhou, Zou   +87 more
core   +2 more sources