Results 11 to 20 of about 124,080 (260)
Moesin Functions as a Lipopolysaccharide Receptor on Human Monocytes [PDF]
Infection and Immunity, 1999 ABSTRACTBacterial endotoxin (lipopolysaccharide [LPS]), a glycolipid found in the outer membranes of gram-negative bacteria, induces the secretion of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), and IL-6 by monocytes/macrophages.
Z N, Tohme, S, Amar, T E, Van Dyke
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Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor [PDF]
Mediators of Inflammation, 2011 The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimuli of the immune response, and it has been shown that P2X7R activation can modulate LPS-induced ...
Elias Leiva-Salcedo +13 more
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PLoS ONE, 2013 B. pseudomallei is a gram-negative bacterium that causes the tropical infection melioidosis. In northeast Thailand, mortality from melioidosis approaches 40%.
Narisara Chantratita +12 more
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Regulation of IL-1 Receptor-Associated Kinases by Lipopolysaccharide [PDF]
The Journal of Immunology, 2002 Abstract IL-1R-associated kinase (IRAK) plays a pivotal role in IL-1R/Toll-like receptor (TLR)-mediated signaling and NF-κB activation. IRAK from leukocytes undergoes rapid activation and inactivation/degradation following IL-1 or LPS stimulation.
Jean, Hu +3 more
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Microglia activated by microbial neuraminidase contributes to ependymal cell death
Fluids and Barriers of the CNS, 2021 The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model.
María del Mar Fernández-Arjona +3 more
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Molecular Pain, 2017 Background JWH015 is a cannabinoid (CB) receptor type 2 agonist that produces immunomodulatory effects. Since skin cells play a key role in inflammatory conditions and tissue repair, we investigated the ability of JWH015 to promote an anti-inflammatory ...
Alicia Bort +6 more
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The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors
Diabetology & Metabolic Syndrome, 2017 Background Recently, we reported that toll-like receptor (TLR)2 and TLR4 localized on the glomerular endothelium in the glomeruli of streptozotocin (STZ)-induced type 1 diabetic mice and high fat diet feed-induced type 2 diabetic mice, and that ...
Koichiro Kajiwara +8 more
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L-selectin — a signalling receptor for lipopolysaccharide
Chemistry & Biology, 1997 The activation of leukocytes by bacterial cell-wall lipopolysaccharide contributes to the pathogenesis of septic shock. We propose that in neutrophils, and possibly other leukocytes, L-selectin can act as a low-affinity lipopolysaccharide receptor.
Malhotra, Rajneesh, Bird, Michael I.
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Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4
Immunology, 2004 SummaryAn understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress in this field during the last 6 years has resulted in the discovery of not only the receptor for LPS – Toll‐like receptor 4
O'NEILL, LUKE ANTHONY JOHN, PALSSON, EVA
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Regulation of macrophage function in inflammation and atherosclerosis
Journal of Lipid Research, 2009 Atherosclerosis can be considered as both a chronic inflammatory disease and a lipid metabolism disorder. Innate immunity pathways have long been suspected to contribute to the initiation and progression of atherosclerosis.
Norihito Shibata, Christopher K. Glass
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