Contribution of receptors to 'Neisseria meningitidis' interactions with human macrophages [PDF]
, 2004 N. meningitidis is a gram-negative human pathogen that invades human cells, evades immune responses and goes on to cause meningococcal disease, sepsis and death.
Abdillahi, Fatumo Abdi
core +6 more sources
Synthetic Toll-Like Receptors for Control of Innate Immunity With Far-Red Light. [PDF]
Adv Sci (Weinh)Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Leopold AV, Verkhusha VV.
europepmc +2 more sources
Genes, Receptors, Signals and Responses to Lipopolysaccharide Endotoxin [PDF]
Scandinavian Journal of Immunology, 2000 C3H/HeJ inbred mice have been very useful for identifying genetic elements responsible for endotoxin‐mediated responses. Depending on the type of assays employed, Tlr‐2, Tlr‐4 and Lps/Ran have been shown to be important in lipopolysaccharide (LPS)‐mediated responses. The concept of a single LPS gene being responsible for the genetic defect found in C3H/
P M, Wong, S W, Chugn, B M, Sultzer
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Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor [PDF]
Mediators of Inflammation, 2011 The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimuli of the immune response, and it has been shown that P2X7R activation can modulate LPS-induced ...
Elias Leiva-Salcedo +13 more
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PLoS ONE, 2013 B. pseudomallei is a gram-negative bacterium that causes the tropical infection melioidosis. In northeast Thailand, mortality from melioidosis approaches 40%.
Narisara Chantratita +12 more
doaj +1 more source
Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state [PDF]
, 2001 Background: Macrophages sense microorganisms through activation of members of the Toll-like receptor family, which initiate signals linked to transcription of many inflammation associated genes.
Aderem, A +17 more
core +1 more source
Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole blood [PDF]
, 2007 Background During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of septic patients.
Thielmann, Matthias +11 more
core +1 more source
Modulation of Toll-like receptor activity by leukocyte Ig-like receptors and their effects during bacterial infection. [PDF]
, 2010 Toll-like receptors (TLRs) are a potent trigger for inflammatory immune responses. Without tight regulation their activation could lead to pathology, so it is imperative to extend our understanding of the regulatory mechanisms that govern TLR expression ...
Martin Vordermeier +5 more
core +1 more source
Microglia activated by microbial neuraminidase contributes to ependymal cell death
Fluids and Barriers of the CNS, 2021 The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model.
María del Mar Fernández-Arjona +3 more
doaj +1 more source
L-selectin — a signalling receptor for lipopolysaccharide
Chemistry & Biology, 1997 The activation of leukocytes by bacterial cell-wall lipopolysaccharide contributes to the pathogenesis of septic shock. We propose that in neutrophils, and possibly other leukocytes, L-selectin can act as a low-affinity lipopolysaccharide receptor.
Malhotra, Rajneesh, Bird, Michael I.
openaire +2 more sources