Results 21 to 30 of about 733,256 (293)

Effects of JWH015 in cytokine secretion in primary human keratinocytes and fibroblasts and its suitability for topical/transdermal delivery

Molecular Pain, 2017
Background JWH015 is a cannabinoid (CB) receptor type 2 agonist that produces immunomodulatory effects. Since skin cells play a key role in inflammatory conditions and tissue repair, we investigated the ability of JWH015 to promote an anti-inflammatory ...
Alicia Bort, Perla A Alvarado-Vazquez, Carolina Moracho-Vilrriales, Kristopher G Virga, Giuseppe Gumina, Alfonso Romero-Sandoval, Scott Asbill   +6 more
doaj   +1 more source

The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors

Diabetology & Metabolic Syndrome, 2017
Background Recently, we reported that toll-like receptor (TLR)2 and TLR4 localized on the glomerular endothelium in the glomeruli of streptozotocin (STZ)-induced type 1 diabetic mice and high fat diet feed-induced type 2 diabetic mice, and that ...
Koichiro Kajiwara, Shunsuke Takata, Thao T. To, Kenyo Takara, Yuji Hatakeyama, Sachio Tamaoki, Richard Peters Darveau, Hiroyuki Ishikawa, Yoshihiko Sawa   +8 more
doaj   +1 more source

Regulation of IL-1 Receptor-Associated Kinases by Lipopolysaccharide [PDF]

The Journal of Immunology, 2002
Abstract IL-1R-associated kinase (IRAK) plays a pivotal role in IL-1R/Toll-like receptor (TLR)-mediated signaling and NF-κB activation. IRAK from leukocytes undergoes rapid activation and inactivation/degradation following IL-1 or LPS stimulation.
Jean, Hu, Randy, Jacinto, Charles, McCall, Liwu, Li   +3 more
openaire   +2 more sources

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. [PDF]

, 2013
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored.
Zsilla Gabriella, Csölle Cecília, Csölle, Cecília, Illes Peter, Flóra Gölöncsér, Gabriella Zsilla, Mária Baranyi, Sperlágh, Beáta, Baranyi, Mária, Kittel Ágnes, Peter Illes, Baranyi Mária, Beáta Sperlágh, Vizi E. Szilveszter, E Sylvester Vizi, Zsilla, Gabriella, Papp Edit, Gölöncsér Flóra, Illés, Péter, Gölöncsér, Flóra, E. Sylvester Vizi, Sperlágh Beáta, Illes P, Vizi, E. Szilveszter, Papp, Edit, Edit Papp, Kittel, Ágnes, Agnes Kittel, Cecilia Csölle, Vizi E. Sylvester   +29 more
core   +2 more sources

Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4

Immunology, 2004
SummaryAn understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress in this field during the last 6 years has resulted in the discovery of not only the receptor for LPS – Toll‐like receptor 4
O'NEILL, LUKE ANTHONY JOHN, PALSSON, EVA
openaire   +4 more sources

Structure-Function Analysis of CD14 as a Soluble Receptor for Lipopolysaccharide [PDF]

Journal of Biological Chemistry, 2000
CD14 is a glycophosphatidylinositol-linked protein expressed by myeloid cells and also circulates as a plasma protein lacking the glycophosphatidylinositol anchor. Both membrane and soluble CD14 function to enhance activation of cells by lipopolysaccharide (LPS), which we refer to as receptor function.
S, Viriyakosol, J C, Mathison, P S, Tobias, T N, Kirkland   +3 more
openaire   +2 more sources

Regulation of macrophage function in inflammation and atherosclerosis

Journal of Lipid Research, 2009
Atherosclerosis can be considered as both a chronic inflammatory disease and a lipid metabolism disorder. Innate immunity pathways have long been suspected to contribute to the initiation and progression of atherosclerosis.
Norihito Shibata, Christopher K. Glass
doaj   +1 more source

Prenatal activation of toll-like receptors-3 by administration of the viral mimetic poly(I:C) changes synaptic proteins, N-methyl-D-aspartate receptors and neurogenesis markers in offspring [PDF]

, 2012
Background - There is mounting evidence for a neurodevelopmental basis for disorders such as autism and schizophrenia, in which prenatal or early postnatal events may influence brain development and predispose the young to develop these and related ...
Stone, T.W., Khalil, O.S., Forrest, C.M., Pisar, M., Smith, R.A., Darlington, L.   +5 more
core   +2 more sources

Propofol exerts anti-inflammatory effects in rats with lipopolysaccharide-induced acute lung injury by inhibition of CD14 and TLR4 expression

Brazilian Journal of Medical and Biological Research, 2013
We investigated the effect of propofol (Prop) administration (10 mg kg-1 h-1, intravenously) on lipopolysaccharide (LPS)-induced acute lung injury and its effect on cluster of differentiation (CD) 14 and Toll-like receptor (TLR) 4 ...
Ling Ma, Xiu-Ying Wu, Li-Hong Zhang, Wei-Min Chen, Akinori Uchiyama, Takashi Mashimo, Yuji Fujino   +6 more
doaj   +3 more sources

Characterisation of bovine leukocyte Ig-like receptors [PDF]

, 2012
Leukocyte Immunoglobulin-like receptors (LILR) are innate immune receptors involved in regulating both innate and adaptive immune functions. LILR show more interspecies conservation than the closely related Killer Ig-like receptors, and homologues have ...
Jones, DC, Singh, M, Allen, RL, Trowsdale, J, Laing, K, Butcher, P, Bhuju, S, Hogan, L, Vordermeier, M   +8 more
core   +4 more sources