Results 11 to 20 of about 105,029 (97)

Expanding functions of lipoprotein receptors

Journal of Lipid Research, 2009
Lipoprotein receptors are evolutionarily ancient proteins that are expressed on the surface of many cell types. Beginning with the appearance of the first primitive multicellular organisms, several structurally and functionally distinct families of ...
Joachim Herz, Ying Chen, Irene Masiulis, Li Zhou   +3 more
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The PCSK9 decade

Journal of Lipid Research, 2012
PCSK9 proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL receptor.
Gilles Lambert, Barbara Sjouke, Benjamin Choque, John J.P. Kastelein, G. Kees Hovingh   +4 more
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Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor

Journal of Lipid Research, 2007
Factors that regulate apolipoprotein E (apoE) secretion by macrophages will have important effects on vessel wall lipid flux and atherosclerosis. Macrophages express the LDL receptor, which binds apoE with high affinity and could thereby affect the net ...
Danijela Lucic, Zhi Hua Huang, De Sheng Gu, Michael K. Altenburg, Nobuyo Maeda, Theodore Mazzone   +5 more
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LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer’s disease

Frontiers in Physiology, 2012
Low density lipoprotein receptor-related protein (LRP) belongs to the low-density lipoprotein receptor family, generally recognized as cell surface endocytic receptors, which bind and internalize extracellular ligands for degradation in lysosomes ...
Carlos eSpuch, Saida eOrtolano, Carmen eNavarro   +2 more
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The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease

Journal of Lipid Research, 2017
The LDL receptor (LDLR) family has long been studied for its role in cholesterol transport and metabolism; however, the identification of ApoE4, an LDLR ligand, as a genetic risk factor for late-onset Alzheimer's disease has focused attention on the role
Courtney Lane-Donovan, Joachim Herz
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Use of next-generation sequencing to detect LDLR gene copy number variation in familial hypercholesterolemia

Journal of Lipid Research, 2017
Familial hypercholesterolemia (FH) is a heritable condition of severely elevated LDL cholesterol, caused predominantly by autosomal codominant mutations in the LDL receptor gene (LDLR).
Michael A. Iacocca, Jian Wang, Jacqueline S. Dron, John F. Robinson, Adam D. McIntyre, Henian Cao, Robert A. Hegele   +6 more
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Hepatic overexpression of methionine sulfoxide reductase A reduces atherosclerosis in apolipoprotein E-deficient mice

Journal of Lipid Research, 2015
Methionine sulfoxide reductase A (MsrA), a specific enzyme that converts methionine-S-sulfoxide to methionine, plays an important role in the regulation of protein function and the maintenance of redox homeostasis.
Yan-Yong Xu, Fen Du, Bing Meng, Guang-Hui Xie, Jia Cao, Daping Fan, Hong Yu   +6 more
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LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages. [PDF]

PLoS ONE, 2015
Within the circulation, cholesterol is transported by lipoprotein particles and is taken up by cells when these particles associate with cellular receptors.
Anna P Lillis, Selen Catania Muratoglu, Dianaly T Au, Mary Migliorini, Mi-Jeong Lee, Susan K Fried, Irina Mikhailenko, Dudley K Strickland   +7 more
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Functions of lipoprotein receptors in neurons

Journal of Lipid Research, 2004
The LDL receptor (LDLR) family is comprised of several multifunctional cell surface proteins that bind and endocytose ligands with diverse biological functions.
Uwe Beffert, Peggy C. Stolt, Joachim Herz   +2 more
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Scavenger receptor-BI is a receptor for lipoprotein(a)

Journal of Lipid Research, 2013
Scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that binds a variety of lipoproteins, including high density lipoprotein (HDL) and low density lipoprotein (LDL), but lipoprotein(a) [Lp(a)] has not been investigated as a possible ...
Xiao-Ping Yang, Marcelo J. Amar, Boris Vaisman, Alexander V. Bocharov, Tatyana G. Vishnyakova, Lita A. Freeman, Roger J. Kurlander, Amy P. Patterson, Lewis C. Becker, Alan T. Remaley   +9 more
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