Results 11 to 20 of about 212,593 (281)
An integrated mathematical model of cellular cholesterol biosynthesis and lipoprotein metabolism [PDF]
, 2018 Cholesterol regulation is an important aspect of human health. In this work we bring together and extend two recent mathematical models describing cholesterol biosynthesis and lipoprotein endocytosis to create an integrated model of lipoprotein ...
Pool, Frances +2 more
core +2 more sources
Unpacking and understanding the impact of proprotein convertase subtilisin/kexin type 9 inhibitors on apolipoprotein B metabolism [PDF]
, 2017 No abstract ...
Packard, Chris J.
core +1 more source
Journal of Lipid Research, 2015 Methionine sulfoxide reductase A (MsrA), a specific enzyme that converts methionine-S-sulfoxide to methionine, plays an important role in the regulation of protein function and the maintenance of redox homeostasis.
Yan-Yong Xu +6 more
doaj +1 more source
Soluble levels of receptor for advanced glycation endproducts and dysfunctional high-density lipoprotein in persons infected with human immunodeficiency virus: ACTG NWCS332. [PDF]
, 2018 The role of high-density lipoprotein (HDL) function and advanced glycation end products (AGEs) in HIV-related atherosclerotic cardiovascular disease (CVD) is unclear.
Aberg, Judith A +5 more
core +1 more source
Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor
Journal of Lipid Research, 2007 Factors that regulate apolipoprotein E (apoE) secretion by macrophages will have important effects on vessel wall lipid flux and atherosclerosis. Macrophages express the LDL receptor, which binds apoE with high affinity and could thereby affect the net ...
Danijela Lucic +5 more
doaj +1 more source
The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease
Journal of Lipid Research, 2017 The LDL receptor (LDLR) family has long been studied for its role in cholesterol transport and metabolism; however, the identification of ApoE4, an LDLR ligand, as a genetic risk factor for late-onset Alzheimer's disease has focused attention on the role
Courtney Lane-Donovan, Joachim Herz
doaj +1 more source
Journal of Lipid Research, 2017 Familial hypercholesterolemia (FH) is a heritable condition of severely elevated LDL cholesterol, caused predominantly by autosomal codominant mutations in the LDL receptor gene (LDLR).
Michael A. Iacocca +6 more
doaj +1 more source
Journal of Lipid Research, 2012 PCSK9 proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL receptor.
Gilles Lambert +4 more
doaj +1 more source
Hepatitis C virus relies on lipoproteins for its life cycle [PDF]
, 2016 Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma.
Alonzi, Tonino +5 more
core +1 more source
Functions of lipoprotein receptors in neurons
Journal of Lipid Research, 2004 The LDL receptor (LDLR) family is comprised of several multifunctional cell surface proteins that bind and endocytose ligands with diverse biological functions.
Uwe Beffert +2 more
doaj +1 more source