Lipoxins as Modulators of Diseases [PDF]
CellsLipoxins were discovered 40 years ago, and since then, their beneficial roles for human health have been confirmed in numerous studies. These small molecules belong to the eicosanoid class of compounds, which are generated metabolically by lipoxygenases.
Uzma Saqib +18 more
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Resolving Inflammation in CKD: The Potential of SPMs and Omega-3 Derivatives as Biomarkers and Therapeutics [PDF]
BiomedicinesChronic kidney disease (CKD) affects more than 10% of the population and is associated with a persistent, low-grade inflammatory state that accelerates tubulointerstitial fibrosis, worsens prognosis, and increases cardiovascular risk. This review aims to
Beata Franczyk +8 more
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Spinal actions of lipoxin A4 and 17(R)-resolvin D1 attenuate inflammation-induced mechanical hypersensitivity and spinal TNF release. [PDF]
PLoS ONE, 2013 Lipoxins and resolvins have anti-inflammatory and pro-resolving actions and accumulating evidence indicates that these lipid mediators also attenuate pain-like behavior in a number of experimental models of inflammation and tissue injury-induced pain ...
Sally Abdelmoaty +9 more
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Can essential fatty acids reduce the burden of disease(s)? [PDF]
Lipids in Health and Disease, 2008 Coronary heart disease, stroke, diabetes mellitus, hypertension, cancer, depression schizophrenia, Alzheimer's disease, and collagen vascular diseases are low-grade systemic inflammatory conditions that are a severe burden on health care resources ...
Das Undurti N
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Lipoxin A4 (LXA4) as a Potential Drug for Autoimmune Uveitis [PDF]
Balkan Med JDas UN.
europepmc +2 more sources
Advances in the Chemistry and Biology of Specialised Pro-Resolving Mediators (SPMs) [PDF]
MoleculesThis review article assembles key recent advances in the synthetic chemistry and biology of specialised pro-resolving mediators (SPMs). The major medicinal chemistry developments in the design, synthesis and biological evaluation of synthetic SPM ...
Lucy Byrne, Patrick J. Guiry
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Lipoxins A4 and B4 inhibit glial cell activation via CXCR3 signaling in acute retinal neuroinflammation [PDF]
Journal of NeuroinflammationLipoxins are small lipids that are potent endogenous mediators of systemic inflammation resolution in a variety of diseases. We previously reported that Lipoxins A4 and B4 (LXA4 and LXB4) have protective activities against neurodegenerative injury.
Izhar Livne-Bar +3 more
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Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]
, 2014 Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Marelli-Berg, F +3 more
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Infection, Inflammation, and Immunity in Sepsis
Biomolecules, 2023 Sepsis is triggered by microbial infection, injury, or even major surgery. Both innate and adaptive immune systems are involved in its pathogenesis. Cytoplasmic presence of DNA or RNA of the invading organisms or damaged nuclear material (in the form of ...
Undurti N. Das
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Frontiers in Pharmacology, 2023 Lipoxygenases (LOX) transform arachidonic acid (AA, C20:4) and docosahexaenoic acid (DHA, C22:6) into bioactive lipid mediators (LMs) that comprise not only pro-inflammatory leukotrienes (LTs) but also the specialized pro-resolving mediators (SPMs) that ...
Philipp Dahlke +5 more
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