Results 31 to 40 of about 111,058 (316)

Tyrosine Kinase Inhibitors Could Be Effective Against Non-small Cell Lung Cancer Brain Metastases Harboring Uncommon EGFR Mutations

Frontiers in Oncology, 2020
Background: The significance of uncommon epidermal growth factor receptor (EGFR) mutations in patients with non-small cell lung cancer (NSCLC) and brain metastasis (BM) remains unclear.
Chunhua Ma, Juncheng Zhang, Juncheng Zhang, Dongjiang Tang, Dongjiang Tang, Xin Ye, Xin Ye, Jing Li, Ning Mu, Zhi Li, Renzhong Liu, Liang Xiang, Liang Xiang, Chuoji Huang, Chuoji Huang, Rong Jiang   +15 more
doaj   +1 more source

Liquid Biopsy in Oral Cancer [PDF]

International Journal of Molecular Sciences, 2018
Oral cancer is one of the most prevalent forms of cancer worldwide. Carcinogenesis is a complex process, in which heterogeneity plays an important role in the development and progression of the disease. This review provides an overview of the current biological and clinical significance of circulating tumour cells (CTCs), circulating tumour DNA (ctDNA),
Óscar Rapado-González, María Mercedes Suárez-Cunqueiro, María Mercedes Suárez-Cunqueiro, Rafael López-López, Laura Muinelo-Romay, Jose-Luis Lopez-Cedrun, Fatima Lousada-Fernandez   +6 more
openaire   +3 more sources

Circulating Genetically Abnormal Cells Add Non-Invasive Diagnosis Value to Discriminate Lung Cancer in Patients With Pulmonary Nodules ≤10 mm

Frontiers in Oncology, 2021
BackgroundLung cancer screening using low-dose computed tomography (LDCT) often leads to unnecessary biopsy because of the low specificity among patients with pulmonary nodules ≤10 mm.
Maosong Ye, Xiaoxuan Zheng, Xiaoxuan Zheng, Xin Ye, Xin Ye, Xin Ye, Juncheng Zhang, Juncheng Zhang, Chuoji Huang, Chuoji Huang, Zilong Liu, Meng Huang, Meng Huang, Xianjun Fan, Xianjun Fan, Yanci Chen, Yanci Chen, Botao Xiao, Jiayuan Sun, Jiayuan Sun, Chunxue Bai   +20 more
doaj   +1 more source

Liquid biopsies for bladder cancer [PDF]

Translational Andrology and Urology, 2017
The development of accurate urinary biomarkers for the non-invasive detection of urothelial bladder cancer (UBC) could transform patient pathways by reducing reliance on cystoscopy, and the identification of highly prognostic (or even predictive) biomarkers could better guide patient management.
Richard T. Bryan, Douglas G. Ward
openaire   +3 more sources

Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway

Journal of Translational Medicine
Background Esophageal squamous cell carcinoma (ESCC) ranks among the most prevalent malignancies of the digestive tract. Due to the absence of obvious symptoms in patients with early-stage ESCC, most cases are diagnosed at advanced stages, highlighting ...
Zhixiong Jiang, Yating Yang, Jinchi Zhou, Xin Li, Qingqing Meng, Xiangyi Yu, Yaxin Xue, Mengyu Li, Yichen Cai, Pengchun Han, Mingjun Jiang, Huizhen Wang, Congrong Liu, Jing Zhao, Lixin Wan, Dengke Bao   +15 more
doaj   +1 more source

DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers

Cells, 2020
Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile.
Chameera Ekanayake Weeramange, Kai Dun Tang, Sarju Vasani, Julian Langton-Lockton, Liz Kenny, Chamindie Punyadeera   +5 more
doaj   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

The Impact of Steatosis on Chronic Hepatitis C Progression and Response to Antiviral Treatments

Biomedicines, 2021
Metabolic derangement is characteristic in patients with hepatitis C virus (HCV) infection. Aside from established liver injury, various extrahepatic metabolic disorders impact the natural history of the disease, clinical outcomes, and the efficacy of ...
Phumelele Yvonne Siphepho, Yi-Ting Liu, Ciniso Sylvester Shabangu, Jee-Fu Huang, Chung-Feng Huang, Ming-Lun Yeh, Ming-Lung Yu, Shu-Chi Wang   +7 more
doaj   +1 more source