Results 151 to 160 of about 240,005 (160)

Beyond Atg8 binding: The role of AIM/LIR motifs in autophagy [PDF]

Autophagy, 2017
Selective macroautophagy/autophagy mediates the selective delivery of cytoplasmic cargo material via autophagosomes into the lytic compartment for degradation. This selectivity is mediated by cargo receptor molecules that link the cargo to the phagophore (the precursor of the autophagosome) membrane via their simultaneous interaction with the cargo and
Dorotea Fracchiolla, Justyna Sawa-Makarska, Sascha Martens   +2 more
exaly   +4 more sources

Analysis of the native conformation of the LIR/AIM motif in the Atg8/LC3/GABARAP-binding proteins [PDF]

Autophagy, 2015
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). This interaction occurs primarily via a conserved motif termed the LC3-interacting region (LIR), or the Atg8-interacting motif (AIM).
Daniel Klionsky, Hana Popelka
exaly   +3 more sources

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The LIR motif – crucial for selective autophagy

Journal of Cell Science, 2013
Summary (Macro)autophagy is a fundamental degradation process for macromolecules and organelles of vital importance for cell and tissue homeostasis. Autophagy research has gained a strong momentum in recent years because of its relevance to cancer, neurodegenerative diseases, muscular dystrophy, lipid storage disorders, development ...
Åsa Birna, Birgisdottir, Trond, Lamark, Terje, Johansen   +2 more
openaire   +2 more sources

BELIMBING PADA TEMBANG LIR-ILIR SEBAGAI SUMBER INSPIRASI PENCIPTAAN MOTIF PENDOK KRAWANGAN TEMPEL

Sanggitarupa, 2022
Star fruit is a fruit that lives in a tropical climate, which has a unique shape that has five circles, like stars. The shape of the star fruit is often associated with several symbolic meanings such as leadership, education, religion, morals and others. One of the excerpts from the song Lir-Ilir mentions that star fruit, which is then interpreted as a
Hesti Pradina, Aji Wiyoko
openaire   +1 more source

In Silico Assessment of LIR Motif-Containing Proteins Binding to ATG8-Family Proteins

Methods in Molecular Biology
Selective autophagic degradation of cellular components has been shown to be mediated by the interaction of LIR motif-containing proteins with ATG8-family proteins. Here, we present a detailed methodology for the in silico evaluation of potential binding between LIR motif-containing proteins and ATG8-family proteins.
Bridget Penman, Ioannis Nezis
exaly   +3 more sources

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy

Autophagy, 2016
Quan Chen, Bin Xia, Yushan Zhu
exaly  

Discovering LC3-interacting region (LIR) motifs in hemorrhagic fever viruses: Implications for host autophagy and viral replication.

Doctor of ...
openaire   +1 more source

Faculty Opinions recommendation of LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2013
openaire   +1 more source

The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes

European Journal of Immunology, 1998
David Cosman, C R Maliszewski
exaly  

Faculty Opinions recommendation of LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy.

openaire   +1 more source