Results 151 to 160 of about 11,750 (172)

Rudolf Steiner and the Jewish Question [PDF]

, 2005
Staudenmaier, Peter
core   +1 more source

The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux. [PDF]

J Cell Biol
North BJ, Ohnstad AE, Ragusa MJ, Shoemaker CJ.   +3 more
europepmc   +1 more source

Transcriptional dynamics uncover the role of BNIP3 in mitophagy during muscle remodeling in <i>Drosophila</i>. [PDF]

Elife
Taoka H, Murakawa T, Kawaguchi K, Koizumi M, Kaminishi T, Sakamaki Y, Tanaka K, Harada A, Inoue K, Kanki T, Ohkawa Y, Fujita N.   +11 more
europepmc   +1 more source

The oncogenic signalosome: SQSTM1/p62 as a master integrator of signaling, metabolism, and autophagy in cancer. [PDF]

Toxicol Res
Choi EJ, Jeon SM.
europepmc   +1 more source

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Characterization of the Interaction of GABARAPL-1 with the LIR Motif of NBR1

Journal of Molecular Biology, 2011
Selective autophagy requires the specific segregation of targeted proteins into autophagosomes. The selectivity is mediated by autophagy receptors, such as p62 and NBR1, which can bind to autophagic effector proteins (Atg8 in yeast, MAP1LC3 protein family in mammals) anchored in the membrane of autophagosomes.
Alexis, Rozenknop, Vladimir V, Rogov, Natalia Yu, Rogova, Frank, Löhr, Peter, Güntert, Ivan, Dikic, Volker, Dötsch   +6 more
openaire   +4 more sources

Drug repositioning identifies potential autophagy inhibitors for the LIR motif p62/SQSTM1 protein

Computational Biology and Chemistry
Autophagy is a critical cellular process for degrading damaged organelles and proteins under stressful conditions and has casually been shown to contribute to tumor survival and drug resistance. Sequestosome-1 (SQSTM1/p62) is an autophagy receptor that interacts with its binding partners via the LC3-interacting region (LIR).
Narjes Asghari, Ali Kian Saei, Marco Cordani, Zahra Nayeri, Mohammad Amin Moosavi   +4 more
openaire   +4 more sources

The LIR motif – crucial for selective autophagy

Journal of Cell Science, 2013
Summary (Macro)autophagy is a fundamental degradation process for macromolecules and organelles of vital importance for cell and tissue homeostasis. Autophagy research has gained a strong momentum in recent years because of its relevance to cancer, neurodegenerative diseases, muscular dystrophy, lipid storage disorders, development ...
Åsa Birna, Birgisdottir, Trond, Lamark, Terje, Johansen   +2 more
openaire   +2 more sources