Results 141 to 150 of about 240,005 (160)

Decoding phospho-regulation and flanking regions in autophagy-associated short linear motifs. [PDF]

Commun Biol
Utichi M, Antonescu ON, Sora V, Marjault HB, Tiberti M, Maiani E, Lambrughi M, Papaleo E.   +7 more
europepmc   +1 more source

A C-terminal cytoplasmic retention motif and nuclear localization signal regulates nuclear import of TP53INP2. [PDF]

J Cell Sci
Shrestha BK, Sjøttem E, Olsvik HL, Odonkor I, Øvervatn A, Brenne HB, Bruun JA, Lamark T, Johansen T.   +8 more
europepmc   +1 more source

A single-stranded DNA virus replicates in the mitochondria of a marine oomycete. [PDF]

Virus Evol
Sakuta K, Krupovic M, Hejna O, Maia C, Horta Jung M, Komatsu K, Moriyama H, Jung T, Botella L.   +8 more
europepmc   +1 more source

AlphaFold2 SLiM screen for LC3-LIR interactions in autophagy. [PDF]

Autophagy
Stuke JFM, Hummer G.
europepmc   +1 more source

A novel lipid-triggered allosteric site modulates LC3-LIR receptor binding activity

Gahlot D, Castin J, Mathur S, Das D, Kumar A, Arun A, Gain C, Sharma M, Pal RK, Jain N, Biswal BK, Singh R, Thukral L.   +12 more
europepmc   +1 more source

Targeting mitophagy for neuroprotection: mechanisms and therapeutic opportunities. [PDF]

NPJ Aging
Yang J, Li J, Hou X, Zheng Y, Zhao Z, Zhou T, Jing T, Kong J, Zhang G, Guo Y.   +9 more
europepmc   +1 more source

Drug repositioning identifies potential autophagy inhibitors for the LIR motif p62/SQSTM1 protein

Computational Biology and Chemistry
MA.M. is supported by international (project on drug repositioning for LC3-interacting region of autophagy protein p62/SQSTM1 in breast cancer) and national (No.
Marco Cordani, Mohammad Amin Moosavi, Narjes Asghari   +2 more
exaly   +5 more sources

Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity

Journal of Molecular Biology, 2021
Autophagy is a highly conserved degradative pathway, essential for cellular homeostasis and implicated in diseases including cancer and neurodegeneration.
Stéphane Mouilleron, Sharon Tooze
exaly   +3 more sources

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Characterization of the Interaction of GABARAPL-1 with the LIR Motif of NBR1

Journal of Molecular Biology, 2011
Selective autophagy requires the specific segregation of targeted proteins into autophagosomes. The selectivity is mediated by autophagy receptors, such as p62 and NBR1, which can bind to autophagic effector proteins (Atg8 in yeast, MAP1LC3 protein family in mammals) anchored in the membrane of autophagosomes.
Volker Dotsch, Frank Lohr, Ivan Dikić   +2 more
exaly   +3 more sources

Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors

Journal of Molecular Biology, 2020
Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors interact with lipidated ATG8 family proteins anchored in the membrane at the concave side of the forming autophagosome.
Trond Lamark, Terje Johansen
exaly   +4 more sources