Results 1 to 10 of about 6,058 (200)
NudEL targets dynein to microtubule ends through LIS1 [PDF]
Nature Cell Biology, 2005 Dynein is a minus-end-directed microtubule motor with critical roles in mitosis, membrane transport and intracellular transport. Several proteins regulate dynein activity, including dynactin, LIS1 (refs 2, 3) and NudEL (NudE-like). Here, we identify a NUDEL homologue in budding yeast and name it Ndl1. The ndl1delta null mutant shows decreased targeting
John A Cooper
exaly +4 more sources
Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1 [PDF]
Scientific Reports, 2022 Regulation of Rho GTPases remains a topic of active investigation as they are essential participants in cell biology and the pathophysiology of many human diseases.
Stanislav Kholmanskikh +2 more
doaj +2 more sources
Increased LIS1 expression affects human and mouse brain development [PDF]
Nature Genetics, 2009 Deletions of the PAFAH1B1 gene (encoding LIS1) in 17p13.3 result in isolated lissencephaly sequence, and extended deletions including the YWHAE gene (encoding 14-3-3epsilon) cause Miller-Dieker syndrome. We identified seven unrelated individuals with submicroscopic duplication in 17p13.3 involving the PAFAH1B1 and/or YWHAE genes, and using a 'reverse ...
Weimin Bi, Tamar Sapir, Feng Zhang
exaly +6 more sources
Nde1 promotes Lis1-mediated activation of dynein
Nature Communications, 2023 Cytoplasmic dynein drives the motility and force generation functions towards the microtubule minus end. The assembly of dynein with dynactin and a cargo adaptor in an active transport complex is facilitated by Lis1 and Nde1/Ndel1.
Yuanchang Zhao, Sena Oten, Ahmet Yildiz
doaj +4 more sources
NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 [PDF]
Proceedings of the National Academy of Sciences, 2010 The type I lissencephaly gene product LIS1, a key regulator of cytoplasmic dynein, is critical for cell proliferation, survival, and neuronal migration. However, little is known about the regulation of LIS1. Here, we identify a previously uncharacterized mammalian homolog of Aspergillus NudC, NudCL2 (NudC-like ...
Yuehong Yang +5 more
openalex +3 more sources
Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1 [PDF]
Biochemical Journal, 2005 For neuronal migration to occur, the cell must undergo morphological changes that require modifications of the cytoskeleton. Several different MAPs (microtubule-associated proteins) or actin-binding proteins are proposed to be involved in the migration of neurons. Therefore we have specifically analysed how two members of the MAP family, MAP1B and LIS1
Eva M. Jiménez‐Mateos +4 more
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Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes. [PDF]
PLoS Biology, 2011 Radial glial cells (RGCs) are distinctive neural stem cells with an extraordinary slender bipolar morphology and dual functions as precursors and migration scaffolds for cortical neurons.
Ashley S Pawlisz, Yuanyi Feng
doaj +3 more sources
Structural basis for cytoplasmic dynein-1 regulation by Lis1 [PDF]
eLife, 2022 The lissencephaly 1 gene, LIS1, is mutated in patients with the neurodevelopmental disease lissencephaly. The Lis1 protein is conserved from fungi to mammals and is a key regulator of cytoplasmic dynein-1, the major minus-end-directed microtubule motor ...
John P Gillies +6 more
doaj +3 more sources
MiR-380 inhibits the proliferation and invasion of cholangiocarcinoma cells by silencing LIS1 [PDF]
Cancer Cell InternationalBackground The objective of this study was to determine the role and regulatory mechanism of miR-380 in cholangiocarcinoma. Methods The TargetScan database and a dual-luciferase reporter assay system were used to determine if LIS1 was a target gene of ...
Zhicheng Wei +7 more
doaj +2 more sources
eLife, 2022 The ability to proliferate is a common feature of most T-cell populations. However, proliferation follows different cell-cycle dynamics and is coupled to different functional outcomes according to T-cell subsets.
Jérémy Argenty +7 more
doaj +2 more sources